Patients with type 2 diabetes are more likely to develop severe forms of coronavirus: this has been known since the start of the coronavirus epidemic. Researchers from the National Institute of Health and Medical Research (Inserm) sought to predict the risks. They thus discovered biomarkers of severe forms, announced Inserm on his site.
The researchers conducted the study on 45 patients hospitalized due to Covid-19, of which 30 were diabetics. In patients, both diabetic and non-diabetic, the most severely affected had fewer lymphocytes, a form of white blood cell, than the others.
“The team observed in particular a particularly low level of cytotoxic CD8 + lymphocytes, immune cells particularly involved in the antiviral response with important functions of recognizing and eliminating infected cells, ”says Inserm.
This therefore makes it possible to refine and improve the care.Fawaz Alzaid, Inserm researcher.
Otherwise, diabetics with severe forms have a particular signature in their sang. They have fewer “monocytes (another type of white blood cell)”, and these show “changes in morphology”.
“These results have important clinical implications as they suggest thatthere is an immune and inflammatory signature specific to diabetic patients at risk of developing a severe form of Covid-19“, explains Fawaz Alzaid, researcher at Inserm.
“If doctors see a decrease in the frequency of monocytes and a morphological change in these cells, they then have the opportunity to identify patients who will need further follow-up and potentially a place in intensive care, “he says.