Adipocyte regulator found in brown-yellow maniac mushroom, a hallucinogenic mushroom

Selected as a cover paper for Organic letters

[투데이경제 유민석 기자] The National Academy of Forest Sciences of the Korea Forest Service announced that they discovered a new natural substance that can control fat cells in ‘Brown-yellow Maniac Mushroom’, which causes hallucination poisoning, through joint research with Professor Ki-hyun Kim of the College of Pharmacy at Sungkyunkwan University.

The new substance discovered by the joint research team is a new hexacyclic ergosterol derivative compound in which ergosterol, a precursor for vitamin D synthesis, and styrylpyrone, an anticancer ingredient, are combined.

It has been demonstrated that natural substances other than novel substances can regulate lipid metabolism in adipocytes by regulating adipogenesis and inducing lipolysis.

The results of this study were recognized for their usefulness and were selected as the 23rd cover paper of ‘Organic Letters’, a prestigious chemistry journal in the field of organic chemistry.

The joint research team has recently discovered a useful substance that inhibits the proliferation of lung and prostate cancer cells in brown-yellow mandarin mushroom.

On the other hand, brown-yellow maniac mushroom is a poisonous mushroom that causes hallucinations and intoxication symptoms such as mental anxiety when taken from forests, so it is forbidden to take it indiscriminately.

This research result is also the result obtained by isolating a specific compound from the extract of the brown-yellow maniac mushroom, and it can be used as a medicine after undergoing various studies such as human safety verification, animal experiments and clinical trials.

“We will continue to strengthen research that explores the new value and usefulness of forest mushrooms so that they can be used as new materials for the future forest bio-industry,” said Han Sim-hee, head of the Forest Microbiology Research Department. We will strengthen research to discover pharmacological functions.”

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