An international team of researchers has identified common vulnerabilities to the SARS-CoV-2, SARS-CoV-1 and MERS-CoV coronaviruses

In a study published Oct. 15 on the journal’s website Science, an international team of nearly 200 researchers from 14 renowned institutions in six countries, including France with the Institut Pasteur and the CNRS, reveals that it has looked into the three deadly coronaviruses SARS-CoV-2, SARS-CoV- 1 and MERS-CoV in order to identify their common diverted cellular pathways and therefore promising targets for their inhibition. In addition, based on the molecular knowledge acquired through this systematic multidisciplinary study of coronaviruses, the group analyzed the medical files of approximately 740,000 patients with SARS-CoV-2, whose characteristics have modified the clinical outcome. , in order to uncover validated therapies with the potential for rapid deployment. Their study results show how molecular information can be translated into practice for the treatment of COVID-19: an approach that can be applied in fine to other diseases.

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