Clinical Advances in Multiple Myeloma Treatments Continue

Multiple myeloma is a condition that, although there is no cure, has extensive and effective treatments.

Doctor Joel López, hematologist oncologist.

Eduardo Najar
Latin Agency for Medicine and Public Health News

Thanks to the various advances in oncological medicine, there are some chronic pathologies that can be treated in order to improve the quality of life of the patient, in the case of multiple myeloma, a group of therapies that must be administered in the individual prevails taking into account a previous evaluation in order to guarantee not only a better prognosis but also a systemic effectiveness and safety.

In an interview with the journal Medicine and Public Health (MSP), Dr. Joel López, hematologist oncologist, detailed the advances in treatments for multiple myeloma, the diversity of therapies.

“Multiple myeloma is a condition that so far has no cure, the treatment is based on keeping the patient in remission over time, in most cases combinations of therapy are made in order for it to be effective for a long time. time, ”said the doctor.

Changes in Multiple Myeloma Therapy

To continue or change with a certain therapy, two important and transcendental factors must be taken into account: one focused on the development of new diseases or long-term complications, which are usually noticeable in a physical way, and another when the individual presents chemical changes, that is, , your body produces certain substances on a large or small scale that can be harmful to your health.

“Basically these patients have no cure, so it is important to closely monitor them while they are in taperia, (…). Treatments change for two reasons, the first because there are several adverse effects or, on the contrary, the patient has developed resistance to a certain procedure and therefore there is progress in therapy. There are specific markers of the protein that produces myeloma that must be taken into account and once these increase in a certain way (greater than 25%) the therapy is changed “, said the doctor.

He further added: “Clinically, an evaluation is also carried out where it must be taken into account if the patient presents new comorbidities or signs of complications, there are also biochemical indicators that are studied in the laboratory, such as the example of the protein already mentioned

Types of therapy

There are a considerable number of treatments for multiple myeloma, these are used to guarantee the patient a favorable long-term prognosis, the effectiveness of the same depends on the receptivity of the individual and previous evaluations made by the bedside oncologist.

“There is from chemotherapy that is the least used to targeted therapy, combinations are used most of the time (…), which can range from radiotherapy in order to reduce side effects in patients and they join to other types of treatments by interventional or orthopedic radiologists to improve bone lesions (…), along with this immunological therapies (immunomodulators, proteasome inhibitors, steroids), in order to bring the patient to the most extensive remission possible ”, says the specialist.

On the other hand, the specialist clarifies that there is a group of treatments that are usually used at first, their intensity depends on the progress and prognosis that each of the patients presents and of course the stage of the condition.

“The first-line therapies are an immunomodulatory combination, this has changed, we can add a monoclonal therapy, this together with the knowledge of whether the patient is a candidate for transplantation or not,” said the doctor.

New treatments

The advances regarding a disease such as cancer have made great progress in recent years, as the doctor mentions, there is a recent therapy where modified cells of the immune system are used in order to try to eradicate malignant cells from the body.

“We are seeing that every day there are more therapies against multiple myeloma, various treatments are used to target the disease, specifically monoclonal antibodies (…). Currently what is being worked the most are therapies of immunological origin. We are soon to see the use of a new therapy where the patient’s own cells are used, altered or modified at the laboratory level to attack those myeloma cells, (…) we use the same immune system for this purpose, in the US. It is already a reality in the US and we hope that Puerto Rico will also have access soon ”, concludes Dr. Joel López.

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