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This study included the results of which were published in the journal "Brian" Analysis of the cases of nine people who died quickly after being infected with covid-19according to the agency "AFP".
The team of researchers at the American Institutes of Health did not monitor any effects of the virus in the brain, but in turn, they found antibodies that bear responsibility for damage to the membranes of blood vessels that cause infections, especially.
This discovery could explain some of the long-term effects of Covid, including headaches, chronic fatigue, loss of smell and taste, sleep problems and intellectual weakness.
It may also open up prospects for future treatments.
The lead author of the study, Avindra Nat, explained in a statement that "Patients often develop neurological complications after COVID-19, but the pathophysiological pathway is poorly understood.".
The researcher continued "We previously showed damage to blood vessels in patients’ brains during autopsies, but we didn’t understand why"adding "I think this research provides us with new elements about this process".
The brains of nine patients, aged between 24 and 73, were compared with ten other people in a control group. The researchers monitored nerve inflammation and the immune response.
And according to what scientists discovered, the antibodies that were secreted as a result of infection with Covid-19, mistakenly targeted the cells that make up the blood-brain barrier that surrounds blood vessels in the brain and tries to counteract foreign substances.
The deterioration that occurs can in turn lead to leakage of proteins, cases of bleeding and clots in the blood, which increases the risk of stroke.
The extravasation can also trigger an immune response to repair damaged cells, causing inflammation.
And the regularity of the vital work of these damaged parts of the brain is exposed to imbalances.
Researcher Avindra Nat said "It is entirely possible for the same immune response to infect patients with long-term COVID-19, resulting in brain injury".
explained that "These findings have very important therapeutic implications".
For example, people with long-term symptoms of Covid can be treated by reducing the production of antibodies responsible for damage to the brain.
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This study, the results of which were published in the journal “Brain”, included an analysis of the cases of nine people who died quickly after being infected with covid-19according to Agence France-Presse.
The team of researchers at the American Institutes of Health did not monitor any effects of the virus in the brain, but in turn, they found antibodies that bear responsibility for damage to the membranes of blood vessels that cause infections, especially.
This discovery could explain some of the long-term effects of Covid, including headaches, chronic fatigue, loss of smell and taste, sleep problems and intellectual weakness.
It may also open up prospects for future treatments.
“Patients often develop neurological complications after Covid-19, but the pathophysiological pathway is not well understood,” the study’s lead author, Avindra Nat, explained in a statement.
“We previously showed the damage to blood vessels in the brain of patients during autopsies, but we did not understand the reason behind this,” he added. “I think this research provides us with new elements about this process.”
The brains of nine patients, aged between 24 and 73, were compared with ten other people in a control group. The researchers monitored nerve inflammation and the immune response.
And according to what scientists discovered, the antibodies that were secreted as a result of infection with Covid-19, mistakenly targeted the cells that make up the blood-brain barrier that surrounds blood vessels in the brain and tries to counteract foreign substances.
The deterioration that occurs can in turn lead to leakage of proteins, cases of bleeding and clots in the blood, which increases the risk of stroke.
The extravasation can also trigger an immune response to repair damaged cells, causing inflammation.
And the regularity of the vital work of these damaged parts of the brain is exposed to imbalances.
“It is entirely possible that the same immune response can infect patients with long-standing Covid-19, leading to brain injury,” said researcher Avindra Nat.
“These findings have very important therapeutic implications,” he explained.
For example, people with long-term symptoms of Covid can be treated by reducing the production of antibodies responsible for damage to the brain.