COVID-19 vaccination: No increased risk of stroke
It is known that vaccinations against those caused by the corona virus SARS-CoV-2 disease caused by COVID-19 side effects can go hand in hand. But an increased one stroke risk after a corona vaccination does not exist. Rather, it can reduce the risk of a stroke.
Vaccines against COVID-19 are highly effective and their benefits far outweigh any possible risks. Nevertheless, side effects such as flu-like symptoms can occur. But there is no increased risk of stroke from vaccination against SARS-CoV-2, reports the German Society for Neurology eV (DGN) in a recent publication Message.
New studies published
New, in the trade magazines “Neurology” and “Annals of Internal MedicinePublished studies show that there is no increased risk of stroke after vaccination against SARS-CoV-2. The two surveys evaluated very large cohorts and came to the same conclusion.
Furthermore, there are initial data that even indicate that the vaccination protects against strokes during COVID-19 disease: In the case of an infection with the coronavirus, vaccinated people did not have half the risk of suffering a stroke than unvaccinated people in the journal “JAMA“ is reported.
There is a stigma attached to vaccines against COVID-19
In the spring of last year, a serious, albeit rare, side effect was observed after COVID-19 vaccinations with vector-based vaccines: Vaccination-associated sinus and cerebral vein thrombosis up, there were deaths.
In the case of vaccinations with mRNA vaccines, this became severe side effect not observed, at least not in a frequency that suggested a connection.
As a result, the vector-based vaccine ChAdOx1 from the manufacturer AstraZeneca was no longer administered to young women, and vaccinated people were also given the main symptom headache sensitized after vaccination and doctors are made aware of the phenomenon of the formation of anti-PF4 antibodies.
Proof of this antibody can identify sufferers before clinical symptoms of sinus and cerebral vein thrombosis appear, allowing early treatment and prevention of this rare complication.
However, a slightly increased risk of hemorrhagic strokes (so-called cerebral hemorrhage) after vaccination with mRNA vaccines has also been described. One in October 2021 in the journal “Nature MedicineIn this regard, a published analysis showed an increased risk on days 1-7 and days 15-21 after vaccination with BNT162b2 from BioNTech/Pfizer (IRR: 1.27 and 1.38).
Since then, all vaccines against COVID-19 have been subject to the Stigma assume they could trigger strokes, a concern that understandably leads to anxiety and contributes to vaccine hesitancy. But the two studies mentioned at the beginning now show that vaccination against SARS-CoV-2 is not associated with an increased risk of stroke.
Stroke rate in SARS-CoV-2 infected significantly higher
In dem in „NeurologyIn the published systematic review, two randomized studies, three cohort studies and eleven registry-based studies were evaluated. A total of 17,481 cases of ischemic stroke were recorded – with a total of 782,989,363 vaccinations. The overall stroke rate was 4.7 cases per 100,000 vaccinations.
Only 3.1 percent of strokes as a result of a SARS-CoV-2 vaccination had one thrombotisch-thrombozytopenische Purpura (TTP) based.
As the authors of the work conclude, the stroke rate after vaccination with the general population comparable – and the TTP, which led to sinus and cerebral vein thrombosis, a very rare complication, at least according to the precautions that were taken.
They also emphasize that the stroke rate in people infected with SARS-CoV-2 has increased significantly higher lies.
No association with major cardiovascular complications
The second study is a current evaluation of the “French National Health Data System”, which examined how often after the first and second administration of vaccines against SARS-CoV-2 in people aged 18 to 75 years cardiovascular events (myocardial infarction, pulmonary embolism or stroke).
A total of 73,325 events were documented in 37 million vaccinated people. In conclusion, the study showed that there was no association between mRNA vaccines and the occurrence of these severe cardiovascular events complications gab.
According to the experts, the first dose of the vector-based vaccine ChAdOx1 was associated with an increased rate of myocardial infarction and pulmonary embolism (RI: 1.29 and 1.41) in week 2 after vaccination association with the occurrence of myocardial infarctions in week 2 after vaccination cannot be ruled out.
With regard to the stroke rate, however, the evaluation showed for none of the vaccines a higher risk.
Risk of stroke more than halved
“The available data show at least for the mRNA vaccines no safety signals in relation to an increased risk of stroke”, concludes DGN-General Secretary Professor Dr. Peter Berlit.
“The fact that both surveys evaluated very large cohorts and both come to the same conclusion gives us additional certainty: mRNA vaccines against SARS-CoV-2 do not increase the risk of stroke, so people should be concerned about this.” don’t stop itto get vaccinated.”
On the contrary: The expert emphasizes that the corona infection is associated with a higher rate of strokes and that the vaccination therefore protects against strokes. This was recently shown in “JAMApublished Korean study.
A total of 231,037 of 592,719 SARS-CoV-2-positive patients during the study period (July 2020 and December 2021) were included in the study. 62,727 were unvaccinated and 168,310 fully vaccinated (two doses of mRNA or vector vaccine) but had each other anyway infected with corona.
The vaccinated study participants were older and had more comorbidities on. Nevertheless, severe or even critical COVID-19 courses were rarer in this group, as was the rate of secondary diseases.
The adjusted risk for ischemic stroke was 0.40 in the vaccinated subjects, meaning that vaccination increased the risk of stroke compared to the unvaccinated group more than halved. (ad)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
- German Society for Neurology eV: Vaccination against SARS-CoV-2 does not increase the risk of stroke, (accessed: 08/30/2022), German Society for Neurology eV
- Stefanou MI, Palaiodimou L, Aguiar de Sousa D, Theodorou A, Bakola E, Katsaros DE, Halvatsiotis P, Tzavellas E, Naska A, Coutinho JM, Sandset EC, Giamarellos-Bourboulis EJ, Tsivgoulis G: Acute Arterial Ischemic Stroke Following COVID-19. 19 Vaccination: A Systematic Review and Meta-analysis; in: Neurology, (veröffentlicht: 24.08.2022), Neurology
- Botton J, Jabagi MJ, Bertrand M, Baricault B, Drouin J, Le Vu S, Weill A, Farrington P, Zureik M, Dray-Spira R: Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following COVID-19 Vaccines in Adults Younger Than 75 Years in France; in: Annals of Internal Medicine, (veröffentlicht: 23.08.2022), Annals of Internal Medicine
- Kim YE, Huh K, Park YJ et al.: Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection; in: JAMA, (veröffentlicht: 22.07.2022), JAMA
- Patone, M., Handunnetthi, L., Saatci, D. et al.: Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection; in: Nature Medicine, (veröffentlicht: 25.10.2021), Nature Medicine
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.