Covid-19 vaccines: reveal which ones generate longer immunity – Health

An article published in the magazine The Proceedings of the National Academy of Sciences (PNAS) who analyzed the durability of immunity against covid-19 provided findings that support booster vaccination as a crucial approach to reduce coronavirus infections, but also provided conclusions about the duration of immunity that some vaccines generate.

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The medical article is titled The durability of natural infection and vaccine-induced immunity against future infection by SARS-CoV-2 (The durability of natural infection and vaccine-induced immunity against future SARS-CoV-2 infections, in Spanish) and used comparative evolutionary approaches as methodology to estimate the durability of immunity and the likelihood of future infections after vaccination with doses of messenger RNA (mRNA) and viral vector vaccines.

The analysis estimated the durability of immunity and the probability of infections after vaccination with BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Modern), ChAdOx1 (Oxford-AstraZeneca) y Ad26.COV2. S (Johnson & Johnson/Janssen).

The levels of anti-Spike (S) immunoglobulin G (IgG) antibodies elicited by each vaccine were evaluated in all four vaccines relative to natural infection.

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In this analysis they concluded that the maximum antibody levels elicited by the mRNA-1273 and BNT1262b2 messenger RNA (mRNA) vaccines “exceeded those of natural infection and they are expected to provide longer-lasting protection against intercurrent infections (median 29.6 months; 5 to 95 percent quantiles 10.9 months to 7.9 years) than natural infection (median 21.5 months; 5 to 95 percent quantiles 3.5 months to 7.1 years )”.

On the other hand, it was found that in relation to the mRNA-1273 and BNT1262b2 vaccines, “the ChAdOx1 and Ad26.COV2.S viral vector vaccines exhibit maximal anti-S IgG antibody responses similar to those of natural infection and expected to provide lower and shorter-term protection against advanced infection (median 22.4 months) and 5 to 95 percent quantiles 4.3 months to 7.2 years, and median 20.5 months and 5 to 95 percent quantiles 2.6 months to 7.0 years, respectively).

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According to researchers Jeffrey P. Townsend, Hayley B. Hassler, Pratha Sah, Alison P. Galvani, and Alex Dornburg of Yale University and the University of North Carolina, these first estimates of the durability of immunity after vaccination provide essential knowledge for decision-making regarding policies to curb long-term transmission, mitigating morbidity and mortality as a result of covid.

“Our quantitative estimates will improve as data on long-term immune responses to SARS-CoV-2 infection and vaccination are generated, providing increasingly precise insights that may refine our estimates not only for available vaccines. today, but also for the vaccines of the future,” they concluded.


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