In a new science, Irish researchers found, through a recent study, that fecal transplants from young mice to older mice helped prevent cognitive decline, and they are now hoping to inspire new treatments in humans, according to the British “Daily Mail” published.
In detail, the study indicated that the microorganisms that live inside the human body affect health and vary with age, noting that friendly bacteria can have beneficial effects on the immune system.
In research conducted at University College Cork in Ireland, they took microorganisms in the stool of younger mice and put them into older mice, then tracked changes in the brain over time.
A more palatable alternative
The results also indicated that the transplantation technology produced specific changes associated with aging in older mice, indicating that future therapies that alter the balance of gut bacteria may help treat aging-related cognitive decline in humans in the future.
signs of aging
When it comes to replenishing the balance of bacteria in humans, the researchers said, a dietary alternative to fecal culture may offer a more palatable solution.
Harnessing the microbiome
As the human body ages, the beneficial bacteria gradually replace the beneficial bacteria that cause chronic inflammation, metabolic dysfunction and disease.
The Irish researchers pointed out that the microorganisms in the gut constitute autoimmunity, but they can also affect the aging of the brain and increase the risk of neurodegenerative diseases.
John Cryan, Marcus Boehme and their colleagues transplanted fecal microbes from young mice aged 3 to 4 months into older mice aged 19 to 20 months. and cognitive function.
trillions of microorganisms
It is worth noting that scientists have shown that 100 trillion amazing microorganisms live in the human intestine, whether they are beneficial or harmful, and the immune system is affected by the balance between the two types.
The Irish team showed that introducing certain types of gut microbes to older lab rodents from younger donors helped them think and remember.
The changes associated with aging were also reflected in the immune system, which made the older mice learn to run around the mazes, and don’t forget how they did it, they were less likely to stress and anxiety, which are common symptoms of dementia.
Later scans also showed that the brains of older mice were regenerated, containing metabolites and patterns of gene regulation similar to those of adolescents.
In addition, the number of people living with dementia globally is expected to triple, to reach about 150 million by 2050 due to the aging of the population worldwide.
Professor Cryan noted that microbes turned back the clock in aging mice, and opened the door to further research on microbial-based interventions in humans, adding that much work was needed first to translate the results for clinical use in humans.
Previous research has found that a daily dose of probiotics over just 12 weeks can lead to significant improvement in elderly patients.
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