How does a high-fat diet affect the risk of allergies?
A link between fast food consumption and allergy risk has been discussed in the professional world for a long time. In a recent study, molecular mechanisms identified, which could contribute to an increased risk of allergies with a high-fat diet.
Led by researchers from China Agricultural University were in the study the effects of a high-fat diet on the allergy risk and the underlying mechanisms are investigated. The study results are published in the journal “Food Science and Human Wellness” released.
Unhealthy diet an allergy risk factor
Unhealthy eating has been suspected for some time risk factor for allergies. Above all, an influence on food allergies is discussed, but also on other allergic symptoms such as Asthma a connection is suspected.
However, the underlying molecular mechanisms have yet to be uncovered, the research team points out. An important role could be played here acetylation of proteins play, which is one of the most important so-called “post-translational modifications” form and influence numerous metabolic processes in the body.
How was the study structured?
For the current study, four-week-old male mice were randomly divided into two groups and fed either a regular diet or a high-fat diet for 24 weeks.
The subsequent laboratory tests of blood and tissue samples showed that the mice with a particularly high-fat diet more often obese and hyperlipidemic were than the animals of the other group. In addition, there were differences in 32 expressed proteins found between the two groups.
Differences in the acetylated proteins
For example, eight acetylated proteins were upregulated on a high-fat diet and 13 proteins were only acetylated in this group. In contrast, eleven other proteins were acetylated only in the mice fed a normal-fat diet.
The affected proteins are mainly involved in the regulation of the energy metabolism and the mitochondrial function involved, add the researchers. “Our results suggest that high-fat diets may promote allergic disease through acetylation of mitochondrial proteins and energy enzymes”according to the research team.
Insight into the molecular mechanisms
According to the experts, the observed differences in acetylation offer insight into the underlying processes molecular mechanisms, which links high-fat diets to allergies. Also deliver the study potential treatment targets for reducing the risk of allergies. (fp)
Author and source information
This text corresponds to the requirements of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- Yanan Sun, Ning Liu, Huihui Wang, Taiqi Qu, Fazheng Ren, Yixuan Li: Comparative acetylome analysis reveals the potential mechanism of high fat diet function in allergic disease; in: Food Science and Human Wellness (veröffentlicht 15.10.2022) , sciencedirect.com
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.