Improved recovery from nerve damage through nutrition
Through intermittent fasting and the resulting change in the activity of the intestinal bacteria could stimulate the so-called axonal regeneration, so that the Significantly improved recovery of damaged nerves.
In a recent study involving experts from Imperial College London (UCL) showed that intermittent fasting promotes axonal regeneration after a Sciatic nerve pinch promoted in mice. The mechanism responsible for this is due to a change in the composition of the intestinal bacteria.
The corresponding study results can be found in the English-language journal “Nature“ to be read.
Difficulty regenerating nerve damage
The potential for regeneration of neurons in the mammalian peripheral nervous system is increased after injury by their slow axonal regeneration rate severely restrictedexplain the researchers.
at axons it is about nerve cell processes, which are also often referred to as neuraxons. Axons transmit impulses from nerve cells to organs and transport molecules to what is known as the celloma.
Exercise can promote axonal regeneration
Factors affecting the ability to axonalen Regeneration include injury-dependent and injury-independent mechanisms. Non-injury mechanisms also include environmental factors such as movementwhich affect the signaling pathways that promote axonal regeneration, the team reports.
Intermittent fasting affects important signaling pathways
According to the experts, it is also possible several of these signaling pathwaysincluding changes in gene transcription and protein synthesis, mitochondrial metabolism and neurotrophin release, activated by intermittent fasting.
So far, however, it has remained unclear whether intermittent fasting die axonal regenerative capacity influenced.
Improved recovery after sciatic nerve crush
In their study, the researchers have now been able to prove that intermittent fasting favorably influences axonal regenerationat least in mice that had suffered sciatic nerve compression.
According to the team, the effect was due to a mechanism involving the gram-positive gut microbiome and an increase in serum levels of the gut bacteria-derived metabolite indole-3-propionic acid (IPA).
3-indolepropionic acid enhances axonal regeneration
The production of 3-indolepropionic acid by the Clostridium sporogenes bacterium is required for efficient axonal regeneration, the experts emphasize.
It has been shown that the administration of 3-indolepropionic acid after sciatica injury actually significantly improves axonal regeneration and accelerates the recovery of sensory function.
The metabolite 3-indolepropionic acid obtained from the microbiome can Regeneration and functional restoration of sensory axons through a facilitate immune-mediated mechanism.
This realization will hopefully one day help create new and efficient treatment options for people to develop by one nerve damage are affected, conclude the researchers. (as)
Author and source information
This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.
Sources:
- Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, Guiping Kong, Luming Zhou, et al.: The gut metabolite indole-3 propionate promotes nerve regeneration and repair; in: Nature (veröffentlicht 22.06.2022), Nature
Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.