2023-05-26 03:33:52
The Korea Institute of Atomic Energy and Medicine announced that the research team led by Dr. Younghoon Son and Haejun Lee identified the effects of long-term exposure to low-dose radiation on Alzheimer’s disease for the first time in the world.
Low-dose rate Low-dose radiation refers to radiation with low radiation intensity and low radiation quantity. Low-dose radiation is a low-dose radiation, such as natural radiation, and generally means radiation of 100 mSv or less.
Recently, studies related to various diseases have been continuously conducted due to social interest in the biological effects of low-dose radiation, and studies on the relationship between low-dose radiation and Alzheimer’s disease have increased in accordance with the increasing trend of degenerative brain diseases that cause dementia such as Alzheimer’s disease due to population aging. need is emerging.
The research team focused on the fact that Alzheimer’s disease is characterized by atrophy of the hippocampus, which is responsible for memory and cognitive function, and observed changes in the hippocampus after irradiating low-dose radiation to the brains of experimental mice with Alzheimer’s disease for about 4 months.
As a result of the experiment, in mice exposed to low-dose radiation, interferon-gamma signaling substances, an inflammation-related factor, were significantly reduced. It was confirmed that it was reduced by about 50% compared to the experimental mice that were not exposed to it.
Through this study, the research team identified that low-dose radiation exposure can be involved in the regulation of Alzheimer’s disease-induced brain inflammatory factors and beta-amyloid control mechanisms, and suggested the necessity and possibility of using low-dose radiation for research on degenerative brain diseases in the future.
The research results were published in the online edition of the International Journal of Radiation Biology on May 12, 2023, an international journal of radiation biology.
Dr. Hae-Jun Lee said, “The results of this study are meaningful in that they were the first to evaluate the effects of low-dose rate and low-dose radiation exposure on brain health vulnerable groups such as Alzheimer’s disease. We plan to continue,” he said.
This study was carried out as part of the ‘Living Radiation Targeting Vulnerable Group-Complex Impact Study on Human Risk Factors’ among the Radiation Safety Material and Medical Technology Development Project of the Ministry of Science and ICT.
Reporter Youngsoo Lee [email protected] View articles
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