Living longer with reduced calorie intake – healing practice

Extend lifespan by reducing calories

Scientific studies have shown that a strict calorie reduction die Life expectancy of animals can prolong. A new study now shows that even a moderate restriction in calorie intake helps people has relevant effects that could also affect life expectancy.

Reduced calorie intake has been shown to improve the health and longevity of laboratory animals, and recent research indicates these benefits may extend to humans as well. The new findings are published in the specialist journal “Immunityreported.

Inflammation is reduced

According to a recent Message Researchers from Yale University in the US show in the new study that moderate calorie restriction in people reduces the production of a protein called SPARC. This curbs harmful inflammation and improves the health of aging people.

The study led by Vishwa Deep Dixitdirector of the Yale Center for Research on Aging, follows a published earlier this year Studywhich identified the main health benefits of moderate calorie intake in humans.

In the new study, Dixit and his co-authors analyzed additional data from the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) clinical study, in which some participants calorie intake reduced by 14 percent for two years while others ate as usual.

The researchers then tracked the long-term health effects. In particular, the scientists analyzed experimental data to identify molecules responsible for the positive effects of calorie reduction and targets for a therapeutic treatment could be.

Improved metabolism

When they looked for genetic changes in the subjects’ adipose tissue after one and two years, they found that those who ate fewer calories had reduced amounts of a protein called SPARC which is linked to obesity, diabetes, and inflammation.

They then examined the effects of the protein on the immune cells and had the health of mice.

The researchers found that SPARC triggered inflammation by targeting anti-inflammatory immune cells called macrophagesinto a pro-inflammatory state.

However, reducing SPARC production by fat cells in mice reduced inflammation, improved blood pressure metabolism and extended their health spans as they got older.

The results could lead to preventive measures against age-related decline in health, according to the director of the Yale Center for Research on Aging. “We now have a better understanding of how SPARC affects inflammation and health span by acting on macrophages”adds Dixit added. (ad)

Author and source information

This text corresponds to the specifications of medical specialist literature, medical guidelines and current studies and has been checked by medical professionals.

Sources:

  • Yale University: Calorie reduction lowers protein linked to the aging process, (Abruf: 15.08.2022), Yale University
  • Seungjin Ryu, Sviatoslav Sidorov, Eric Ravussin, Maxim Artyomov, Akiko Iwasaki, Andrew Wang, Vishwa Deep Dixit: The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging; in: Immunity, (veröffentlicht: 12.08.2022), Immunity
  • Timothy W. Rhoads & Rozalyn M. Anderson: Caloric restriction has a new player; in: Science, (veröffentlicht: 10.02.2022), Science

Important NOTE:
This article contains general advice only and should not be used for self-diagnosis or treatment. He can not substitute a visit at the doctor.

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.