now,ChoshinkanBecome the main burden of society, is there any medicine to treat the new crown?Studies have found that low dosesnaltrexonerightChoshinkanTreatment is beneficial. First of all, we have to mention an example of naltrexone in the treatment of alcohol and drug addiction.
Claudia Ann Christian is a famous American actress. She has been addicted to alcohol for more than ten years and feels controlled by a life, like a driver who is not in the “driver’s seat”. She spent a lot of money for more than ten years and tried various treatments, but it didn’t work.Later Sinclair therapy was used, i.e.naltrexone(Naltrexone) successfully cured alcohol addiction.
Naltrexone was approved by the FDA in 1984 for the treatment of heroin addiction. It binds to opioid receptors and plays a competitive space-occupying role, thereby treating heroin addiction.
Low-dose naltrexone has 4 major effects or may be treatablecancer！
Later, scientists also discovered that the use of naltrexone in small doses has a completely different purpose besides fighting addiction.
1. Potential role in the treatment of tumors
In 1983, Dr. Ian S. Zagon and Dr. Patricia J McLaughlin, Penn State Hershey Medical Center, in the journal Science Published a paper describing for the first time that low-dose naltrexone has a significant inhibitory effect on neuroblastoma growth in mice[1]。
The researchers gave neuroblastoma-inoculated mice daily subcutaneous injections of 0.1, 1, or 10 mg/kg of naltrexone.
Compared with controls injected with distilled water, mice injected with low-dose naltrexone (0.1 mg/kg body weight) increased survival time by 36% and delayed tumor appearance by 98%.
Low-dose naltrexone promotes endorphin production through the endogenous opioid receptor system.The most important function of endorphins is to enhanceimmunity, to increase the number and function of immune cells, improve the overall immune function, so it can block the occurrence of cancer. If there is an injury, endorphins also help the wound heal better.
2. TreatmentAIDS
New York doctor Dr. Bernard Bihari, a Harvard graduate, becauseAIDSThe epidemic in the United States began in 1985 to find ways to help AIDS patients restore their immune systems.
Clinical trials have shown that low-dose naltrexone can protect AIDS patients from repairing their already damaged immune systems.
About 31% of patients in the control group who received placebo developed opportunistic infections during the trial; in contrast, none of the 22 patients who received low-dose naltrexone developed any opportunistic infections[2]。
3. Treats Multiple Sclerosis
As of 2004, Dr. Bihari had treated nearly 400 patients with multiple sclerosis.Only two of these patients had a new flare after receiving low-dose naltrexone[3]。
4. Treats Irritable Bowel Syndrome
In 2006, Israel published a study of 42 patients with irritable bowel syndrome (IBS). Patients with irritable bowel syndrome were given 0.5 mg of low-dose naltrexone daily for 4 weeks and their pain-free days and symptom relief were measured.Low-dose naltrexone was found to be effective in more than 75% of patients and the drug was well tolerated[4]。
Low-dose naltrexone improves COVID-19 symptoms
In a study of the effectiveness of low-dose naltrexone on long-term new crowns, 40 (76.9%) of the 52 subjects were women, with a median age of 43.5 years; the median time from diagnosis of new crown to enrollment was On day 333, 38 participants (73.1%) started low-dose naltrexone.
After two months, a total of 36 (69.2%) participants completed the questionnaire. Improvements were seen in 6 of the 7 parameters tested, with significant improvements in limitations of activities of daily living, energy levels, pain levels, concentration levels and sleep disturbances, and slight improvements in mood.Significant improvement in the incidence of specific symptoms such as depressed mood, personality changes, brain fog, joint pain, etc.[5]。
Symptoms of fibromyalgia are common among COVID-19 patients.A study found that 30% of people with long-term new crown will have the problem[6]. Fibromyalgia is a state of increased microglial activity and inflammation in the central nervous system. Once activated, these cells produce pro-inflammatory factors that cause symptoms such as hyperalgesia and fatigue.
In an 8-week, single-blind, crossover design trial, researchers found that people with fibromyalgia who used 4.5 mg of low-dose naltrexone nightly had more than a 30 percent reduction in symptoms compared to a placebo group. , the drug improved mechanical and thermal pain thresholds; side effects (including insomnia and vivid dreams) were rare and described as mild and transient; and multiple proinflammatory cytokines, including interleukins, were significantly reduced.
In addition, the drug improved mechanical and thermal pain tolerance thresholds, and side effects (including insomnia and vivid dreams) were rare and described as “mild and transient.” Several pro-inflammatory cytokines, including interleukins, were also significantly reduced in patients with fibromyalgia.
Chronic fatigue syndrome is also a common problem with the new crown. In January 2020, the British Medical Journal published three studies on the positive therapeutic effect of low-dose naltrexone on Epstein-Barr virus (EBV)-related chronic fatigue case report[7]。
Why does low-dose naltrexone have a therapeutic effect on many diseases?
Naltrexone is used to treat opioid and alcohol addiction in doses ranging from 50-200 mg per day, a level that completely blocks both endogenous opioids (endorphins) and exogenous opioids ( such as heroin).
The low dose is 1/10 to 1/100 of the normal dose, which is 0.5 to 4.5 mg/day.
Each naltrexone drug comes in two forms, called isomers, that are mirror images of each other (left-handed and right-handed), and just like a person’s left and right hands, usually only one isomer provides a therapeutic effect. Naltrexone is unique in that both isomers have different therapeutic effects.
1. Increase the release of endogenous beta-endorphins
Studies have shown that low-dose naltrexone acts on opioid receptors, increasing endogenous opioid levels and stimulating its own production of endorphins. A 2008 study found that endorphins were elevated even 1 month after discontinuation of low-dose naltrexone less than 5.0 mg[8]。
90% of endorphins are secreted at 2-4 in the morning, so go to bed on time and don’t stay up late, especially don’t stay up late all night to help the normal secretion of endorphins.
2. Regulates Opioid Growth Factors
There are several subtypes of opioid receptors in the human body, one of which is also called opioid growth factor receptor (OGFr). When OGF binds to the OGFr receptor, cell proliferation is altered. Regulating the opioid growth factor (OGF)/opioid growth factor receptor (OGFr) axis can be involved in the regulation of tumor growth and proliferation.
When the OGF/OGFr axis is upregulated, tumor growth is inhibited. Low-dose naltrexone upregulates the OGF/OGFr axis, thereby inhibiting tumor growth and helping to treat tumors.
In addition, it is beneficial for the treatment of autoimmune diseases, including multiple sclerosis, Crohn’s disease, diabetes, cancer, and mental disorders.
3. Reduce pro-inflammatory cytokines and increase anti-inflammatory cytokines
Immune system coordination depends on the body’s ability to maintain a balance between cytokines that promote and reduce inflammation. Low-dose naltrexone can reduce a variety of inflammatory cytokines through a variety of ways to reduce inflammation.
Low-dose naltrexone reduces Toll-like receptor-4 signaling that induces neuroinflammation. Toll-like receptors (TLRs) are part of the human immune system, the first line of defense against microbial invasion, and have the ability to recognize and activate pathogens and endogenous signaling molecules.
Therefore, low-dose naltrexone is helpful for relieving the symptoms of the new crown.
Low-dose naltrexone may improve spike protein, vaccine injury
At least two-thirds of the world’s people have been injected with the new coronavirus vaccine, and the main component of the vaccine is the spike protein.
At least 1,200 scientific studies have pointed out that the spike protein will cause harm to the human body at the level of cells, tissues and organs. The main pathological mechanism is: the spike protein induces an inflammatory response and activates monocytes in various organs in the body. Most notably affecting the brain (brain fog, dementia, mood disorders, mental disorders), heart and endocrine, it’s like setting fire to yourself.
In addition, the spike protein reactivates the latent virus, further suppressing immunity, creating a vicious circle. Other effects include microvascular damage, mitochondrial dysfunction, and autoimmune diseases, among others.
Theoretically, low-dose naltrexone has the effect of reducing systemic inflammation/neuroinflammation.
Low-dose naltrexone can inhibit various inflammatory factors and reduce the inflammatory response of the systemic system. Low-dose naltrexone can also inhibit the activation of microglia in the nervous system and reduce the toxic effects of reactive oxygen species and other potential neuroexcitatory and neurotoxic chemicals, resulting in neuroprotective effects on the brain and nerve cells.
Implications from the efficacy of low-dose naltrexone
The multifunctional use of low-dose naltrexone has many implications.
The human body’s natural self-recovery regulation mechanism, once destroyed by foreign drugs, viruses, poisons, etc., may cause disorders, such as addiction. At this time, in addition to forcibly blocking external stimuli (drugs), the most fundamental treatment still needs to be repaired naturally by the human body to achieve the final return to normal curative effect.
The main idea of medical treatment is to treat symptoms, which is coping. At present, it is mainly a disease, a target, and a drug treatment idea.
And naltrexone, a 38-year-old drug for drug addiction, can actually treat some intractable chronic diseases when the dose is reduced to a very low level.
This shows that the human body is a complex and multi-dimensional delicate system. Little is known about the human body, and little is known about the close connections between the brain, immunity, and various organs of the body.
And some traditional remedies and natural remedies can carry out holistic treatment from a deeper and microscopic perspective. The subtleties of the human body need to be explored and mastered slowly.
Living in a chaotic world, with a healthy mind, just seeHealth 1+1！
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Responsible editor: Li Qingfeng