For the first time, the scientist managed to create perfect human transparency. Using microscopic imaging, they were able to reveal complex basic structures at the cellular level. As a result, the organ cards can be observed as arrays for 3D bioprinting technologies. In the coming years, this could be used to implement artificial organs for many patients if necessary. The research results come from the Technical University of Munich (TUM), the Helmholtz Zentrum München and the Ludwig-Maximilians-Universität München (LMU).
Analyzing the structural complexity of human organs has always been a major problem, as technology is insufficient to map them at the cellular level. The latest tissue cleaning experiments have therefore enabled scientists to carry out initial cellular studies of basic transparent mouse organs in three dimensions. Human organs are mostly solid because insoluble molecules like collagen grow in tissues that have been increasing for decades.
For this reason, the conventional solvent used to create transparent mouse organs does not act on human organs, mainly on adults. The researchers said that we need to change our perspective and start over to discover new chemicals that can make humanity transparent. After numerous attempts, the team of scientists found that a solvent called CHAPS can create small holes in all rigid human organs. With CHAPS, the additional solution can penetrate deep into the human organs and convert them into a transparent structure.