new treatment perspectives linked to the microbiota

THE ESSENTIAL

  • Chronic conditions have been on the rise for over 60 years all over the world.
  • INRAE’s work opens up new avenues for patients in terms of diagnosis, preventive nutrition and therapy.

From an animal experiment, researchers from INRAE have for the first time provided proof that intestinal inflammation and the alteration of the microbiota that accompanies it can support each other and generate chronic diseases. “Thus, they show that the simple generalization of inflammation can durably alter the symbiosis between humans and their microbiota, preventing a return to normal, even 40 days after stopping induction”, specifies the research institute. These results were published on November 6 in the journal Microbiome.

A balanced dialogue between humans and their gut microbiota is essential

Crohn’s disease, ulcerative colitis, obesity, diabetes, liver disease, Parkinson, Alzheimer’s, autism, cardiovascular diseases… Chronic diseases have been on the rise for more than 60 years all over the world. INRAE’s work opens up new avenues for patients in terms of diagnosis, preventive nutrition and therapy.

A balanced dialogue between humans and their gut microbiota is essential for maintaining health. From birth, the body provides “the lodging and the table” the microbiota, which in return provides it with protective functions, keeping its natural defenses awake and preventing the proliferation of bacteria from the environment inside the body.

Complex interactions

Nothing happens in the intestinal microbiota that does not impact the intestinal wall, immunity, and vice versa. These complex interactions guarantee the functional robustness of the intestinal ecosystem, which interacts with all the organs.

Under normal conditions, even after a major disturbance, following taking antibiotics for example, our microbiota returns to its initial state. In the context of chronic diseases, the INRAE ​​research team has put forward the hypothesis – since validated – that the alteration of the microbiota and the inflammation that accompanies it prevents a return to balance.




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