sending time2021-08-05 18:00
IBS research team develops a brain organoid culture platform similar to the brain environment
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(Daejeon = Yonhap News) Reporter Joo-Young Park = Research Fellow Seung-Woo Cho, Research Fellow at the Center for Nanomedicine at the Institute for Basic Science (IBS) announced on the 5th that they had succeeded in producing mini-brains (organoids) through a culture platform similar to the real human brain.
It is as sophisticated as that of a newborn’s brain, and its size is also larger than before.
Brain organoids are made by culturing induced pluripotent stem cells (stem cells that can be differentiated into various cells by dedifferentiating somatic cells).
Existing brain organoids had limitations, such as the lack of a culture scaffold not realizing the environment necessary for brain development, so the maturity level was low to that of a fetus, and the bigger the organoid, the more difficult it was to supply oxygen and nutrients to the center, resulting in cell death.
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The research team first developed a three-dimensional hydrogel in the form of a jelly similar to the extracellular matrix (extracellular substance) of the brain.
Then, a microfluidic chip (a micrometer, that is, a chip that can process various samples by controlling the flow of liquid in a micro tube with a diameter of 1 millionth of a meter) made of micro channels is introduced, effectively delivering oxygen and culture solution to the center of the organoid made it to be
As a result of the brain organoid culture experiment using the developed hydrogel, the neuroepithelium that constitutes the cerebral cortex developed, and a large amount of brain wrinkles were generated.
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In addition, it was confirmed that various brain cells such as neurons, astrocytes, and microglia were expressed.
The research team explained that it is twice the size of brain organoids of 2 to 3 mm and has more developed nerve functions.
“We have developed a new brain organoid culture platform using nano technology,” said Seung-Woo Cho, a research fellow.
The results of this study were published in the online version of the international academic journal ‘Nature Communications’.
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