Studies have found that pregnancy can reduce the risk of colorectal cancer, and estrogen has a protective and anti-cancer effect on the large intestine, but pregnancy also increases insulin secretion, produces insulin resistance, and increases the risk of colorectal cancer. 9% reduction; pictured is a situational photo. (Picture taken from freepik)
[Health Channel/Comprehensive Report]Recently, many people are curious about “Will pregnancy make colorectal cancer worse?” In this regard, the doctor said that a study found that pregnancy can reduce the risk of colorectal cancer by 9%, but this is because the anticancer effect of estrogen and insulin resistance are offset.
Qian Zhenghong, a gastrointestinal, hepatobiliary physician at Keelung Chang Gung Hospital, posted on his Facebook fan page “Qian Zhenghong Gastroenterology and Hepatobiliary Physician“The article mentioned that one article was published in “JNCI cancer SpectrumIn a German study in the journal, researchers included 2,650 adult women with colorectal cancer and 2,175 healthy women of the same age as a control group. The analysis found:
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1. Pregnancy reduces the risk of colorectal cancer by 9%, especially right-sided colorectal cancer.
2. Breastfeeding for more than 1 year reduces the risk of colorectal cancer by 26%, especially the right colorectal cancer.
3. Using birth control pills for more than 9 years reduces the risk of colorectal cancer by 25%, especially for left-sided colorectal and rectal cancers.
4. The use of hormone replacement therapy (menopause) reduces the risk of colorectal cancer by 24%.
5. The age of first menstruation has nothing to do with the occurrence of colorectal cancer.
6. Entering menopause after the age of 50 reduces the risk of colorectal cancer by 17%.
Qian Zhenghong said that the research is mainly to analyze the effects of physiological female hormones and external supplementary hormones on colorectal cancer. Pregnancy increases estrogen by 10 times, and “estrogen has a protective and anti-cancer effect on the large intestine”, but pregnancy also It will increase insulin secretion, produce insulin resistance, and increase the risk of colorectal cancer. The good and the bad are offset by the coming and going. Therefore, according to statistics, pregnancy can reduce the risk of colorectal cancer, but only by 9%.
Studies have pointed out that hormone supplementation in menopausal women can reduce the risk of colorectal cancer because there are estrogen receptors on the colorectal cells, and the local estrogen concentration in the large intestine increases, which can reduce the production of carcinogenic secondary bile acids and the damage and mutation of colorectal DNA. Inhibits cell proliferation in colorectal tumors.
However, there are other issues with hormone supplementation, such as a possible increased risk of coronary artery disease, breast cancer and stroke, so hormone therapy is not yet suitable as a way to fight colorectal cancer, the study said.
Qian Zhenghong believes that there is no need to change his fertility plan due to the research results, but through research, we can dispel myths and give some encouragement to mothers who are struggling to give birth and breastfeeding, and the risk of colorectal cancer in pregnancy will still be less.
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