Psoriasis, a new way of treatment?

Psoriasis is characterized by the appearance on the skin of red patches covered with scales. The latter are due to “a pathological hyperproliferation of keratinocytes, the cells which mainly make up the epidermis”, recalls Inserm. This inflammatory reaction “results from the infiltration of the epidermis and the dermis by immune cells, in particular by a subpopulation of T lymphocytes”.

It is to counter this phenomenon that Magali Savignac’s team at the Toulouse Institute of Infectious and Inflammatory Diseases * decided to work on a means of hindering the mechanism of action of immune cells in the skin. Their hypothesis: inhibiting calcium channels present on the surface of these cells would reduce the manifestations of the disease by fighting against inflammation.

Inhibit calcium channels

To validate it, they first confirmed the presence of these channels called Cav1.4 on the surface of cells responsible for inflammation on biopsies of psoriatic lesions. Then, they “wanted to block this channel to observe the consequences on the production of cytokines in different models of psoriasis study”. How? ‘Or’ What ? Using a product already marketed in the treatment of hypertension, which acts by inhibiting Cav1 channels in the blood vessels: nicardipine.

The result was conclusive: “the production of cytokines by lymphocytes drops in the presence of nicardipine”. This is sufficient evidence to open a “new therapeutic field based on the development of drugs that specifically target these calcium channels to reduce the symptoms of psoriasis”, concludes Magali Savignac.

* in collaboration with researchers from the Center for Integrative Biology (CNRS), clinicians from the CHU Larrey and the Pierre Fabre Cosmétiques laboratories

Violence against women: 1 case every 3 minutes

Source: Destination Santé

Leave a Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.