The role of bystander T cells in infectious diseases… Published KAIST review papers

“Studying the process of bystander T cell activation in COVID-19”

The Korea Advanced Institute of Science and Technology (KAIST), a research team led by Professor Eui-Chul Shin, Dr. Ho-Young Lee, and Seong-Ju Jeong, a graduate student at the Graduate School of Medical Sciences, emphasized the role of ‘bystander T cells’ in infectious diseases. It was announced on the 31st that it had published an invitation review paper.

In this review paper, Professor Eui-cheol Shin’s research team introduced the role of bystander T cells in various infectious diseases and the principles that regulate them, and suggested future research directions that can be applied to disease treatment.

When the human body is infected with a virus, T cells are activated to perform immune activity.

In response to a virus, only certain T cells are activated and the rest remain inactive is called a selective immune response, which is achieved by recognizing the antigenic peptide of the virus by T cells.

However, depending on the type of virus and the patient’s immune system, activation of T cells unrelated to the virus may occur, which is called bystander T cell activation.

It is known that bystander T cell activation is induced by cytokines (signaling substances that control and stimulate the body’s immune system) regardless of the presence of viral antigen peptides.

An understanding of this process is necessary to elaborately understand the immune response of patients with complex infection histories.

Professor Eui-cheol Shin’s research team newly discovered the activation of bystander T cells as the cause of severe hepatocyte destruction in patients infected with hepatitis A virus, which was prevalent in Korea in the 2010s, and reported the results of the study in Immunity, an immunology journal in 2018. have done

This is the world’s first paper to systematically prove the role of bystander T cells in human diseases.

The research team is currently conducting follow-up studies to reveal bystander T cell activation characteristics and related mechanisms in viral and oncological diseases.

In particular, we are conducting research on the activation and role of bystander T cells in the novel coronavirus infection (COVID-19), which is prevalent around the world.

Dr. Ho-Young Lee said, “In recognition of my contribution to pioneering and expanding the research field of bystander T cell activation in the immune world, I have published an invitation review paper. will,” he said.

/yunhap news

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