According to the industry on the 22nd, a research team from Purdue University in the U.S. and the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) affiliated with the U.S. National Institutes of Health (NIH) reported that the active metabolite of vitamin D is involved in inhibiting inflammation, which is also helpful in severe COVID-19 patients. It could potentially be helpful. The results of this study were published in the international scientific journal ‘Nature Immunology’ on the 11th.
A vitamin is a compound word of vital (vitality) and amine (a type of organic compound) that are essential for the body. It was only after this naming was made that it was discovered that not all vitamins were amine-based substances. Vitamins cannot be synthesized in the body, so they must be ingested or absorbed from the outside.
Among them, vitamin D plays an important role in bone maturation and mineralization in the blood, as well as helping to boost immunity. The research team confirmed that vitamin D could reduce inflammation caused by T cells, which are immune cells. T cells play an important part of cellular immunity in the immune system. When the virus that causes COVID-19 enters the body, it kills the virus and infected cells.
The inflammatory response in the lungs caused by T cells is known to be the biggest risk factor among existing cases of COVID-19 patients. Several studies have found that vitamin D is effective in reducing this inflammatory response, but the exact mechanism is unknown.
If it is confirmed how vitamin D works to reduce inflammation, the research team explains that it will be a stepping stone to develop a much more effective new drug by understanding how COVID-19 and drugs work.
The research team analyzed lung cells from eight patients infected with COVID-19 and found that some of the immune cells exacerbated lung inflammation by overacting. In addition, after discovering that the COVID-19 virus can induce immune complement activation in the body, they studied how to suppress it and improve inflammation caused by the activation response.
Complement is a substance that supplements the immune function, and when an antigen or antibody complex and a complement protein are combined, it promotes the complement activation reaction and causes an immune response. When the complement immune response is activated, the secretion of inflammatory substances is activated at the site of infection.
The researchers also explained why vitamin D may reduce the inflammatory response. In a general infection situation, Th1 cells (helper T cells), a type of T cell, induce an immune response and cause a pro-inflammatory response that promotes an inflammatory response. Then the anti-inflammatory reaction begins. According to the research team, vitamin D helps speed up the conversion of T cells from the pro-inflammatory phase to the anti-inflammatory phase.
Based on this, the team speculated that vitamin D could potentially be helpful for patients with severe inflammation caused by Th1 cells.
The research team said that this ‘infectious’ phase of Th1 cells appears to continue unabated, especially in patients with COVID-19 who suffer from severe inflammation. The researchers speculate that this may be because the patient is vitamin D deficient or the cellular response to vitamin D is atypical.
The research team hypothesized that intravenous administration of vitamin D in the form of a highly concentrated metabolite to existing therapies could further help people recover from COVID-19 infection. However, the research team is still cautious about the use of vitamin D to combat COVID-19. This is because it has not yet undergone human clinical trials.
“We found that a special form of vitamin D, rather than the over-the-counter form of vitamin D, had the potential to reduce inflammation, and we identified why and how it works,” the researchers said.
Majid Kazemian, professor of biochemistry at Purdue University, said, “You should not take more than the recommended amount of vitamins for the treatment of COVID-19. requested
(Seoul = News 1)