Using synchrotron to study the anti-inflammatory effect of ‘Pega’, an herb that can be eaten with chili paste.
Synchrotron scientists with researchers SUT-Lecturer of Thai Traditional Medicine, Phetchaburi Provincial University, studied the anti-inflammatory effect of a perennial pod shaped like a sword named “Peka” or in some localities called “fah tongue”, which is a medicinal plant that is eaten with chili paste on the table. food The results of the analysis showed that it was actually anti-inflammatory. and detect changes within cells with synchrotron light
Professor, Pharmacist, Dr. Kriengsak Uamkeb, Lecturer of Pre-Clinical Program Suranaree University of Technology together with Ajarn Benjawan Dunkunthod, a lecturer in the Department of Thai Traditional Medicine Faculty of Nursing and Health Sciences Phetchaburi Rajabhat University The anti-inflammatory effect of Peka was studied. in collaboration with Dr. Kanchana Thamnu, a light beam system scientist from the Synchrotron Light Research Institute (Public Organization) Ministry of Higher Education, Science, Research and Innovation (TSU) to bring synchrotron light to analyze
Researchers are interested in the anti-inflammatory effects of Peka. The basic knowledge of inflammation was applied to design experiments. Inflammation is the body’s normal response to things that damage the body’s tissues. During inflammation, plasma and white blood cells move from the blood to the inflamed tissue. The most active cells in the inflammation process are “macrophages,” which are activated by certain chemicals and bacterial compounds such as lipopolysaccharides. Interferon gamma
Stimulated macrophages undergo morphological changes. Generation of free radicals (ROS) within cells and cytokines involved in inflammation. Studies and past research have found that vegetables, fruits and whole grains contain antioxidants such as phenolic compounds. and flavonoid group beneficial to human health Reduces the risk of developing chronic diseases such as cancer, heart disease and diseases associated with inflammatory processes.
In a study on the antioxidant and anti-inflammatory activity of Peka extract. The team studied in a model of activated macrophages. Lipopolysaccharides with Interferon Gamma and the results of the research found that Pega extract has anti-inflammatory properties. by inhibiting the generation of free radicals and cytokines involved in inflammation
The researchers also applied the SR-FTIR microspectroscopy technique. at the light beam system 4.1 of the Synchrotron Light Research Institute to measure changes in biomolecules within macrophages For use as additional information in conjunction with traditional measurement techniques. To assess the efficacy of extracts or drugs that can fight free radicals and anti-inflammatory or not.
This research, the research team hopes, will benefit the study and search for a group of medicinal plants with pharmacological activity. as well as to make it more convenient and faster for studying the effects of herbs in the future