It was a gala evening, a theater reunion party orchestrated by Alex Vizorek who, if he did not leave with the Molière of humor, will have been able to show finesse and elegance to pilot an evening which might sometimes run out of steam. A night of Molières which awarded 19 prizes to eleven shows, including a Shakespeare, “As you like it”, king of the event with four statuettes. He dominates a prize list tinged with good humor and lightnessnot without dismissing the emotion, a nice skewer of shows that can still be discovered or will resume soon.
On June 1, 2022, Roche and its subsidiary TIB Molbiol developed three test kits in response to the virus outbreak. “smallpox monkey” (Monkeypox virus) happening now in the past 2 weeks Outbreaks of the monkey pox virus (Monkeypox) have been reported in several countries. both in Europe and North America which is the area that has never encountered an outbreak of this type of virus before
Smallpox from animals to humans
for Monkeypox (Monkeypox) It was first discovered in 1985 among monkeys bred for research purposes. However, the virus is presumed to be transmitted from wild animals such as rats to humans or from person to person.
in the West Africa and Central Africa An average of 2-3 thousand cases can be found per year, but can be found outside the African continent. Most of which are related to trips to Africa. or importation of infected animals. Treatments and vaccines developed for smallpox It was speculated to be helpful in limiting the spread of monkeypox.
virus testing kit
Thomas Schinacker, chief executive officer of Roche Diagnostics, said the diagnostic tool plays an important role in the response and controlling the challenges that arise in public health especially the development of countermeasures, such as follow-up efforts and treatment strategies, by “Roche” developed a new type of test kit to help detect the virus monkey pox This will help to track the epidemiological spread.
3 types of test kits
– The first type of test set It is used to detect viruses in the orthopox group. (Orthopoxvirus), which covers all monkeypox viruses found in West Africa. and Central Africa (collectively, Species [clades])
– The second type of test set It will only test for the monkey pox virus. (in the West African species and Central Africa)
– While the third type of test series It was developed for researchers who wished to obtain information from the first two test kits simultaneously. This test can detect both orthopox virus. Ready to provide information on whether the smallpox virus was detected or not. (in the West African species and Central Africa)
“This monkey pox virus test kit It is a research test kit used in many countries around the world.”
Quantitative PCR Technology Test Kit
Orthopox / Monkeypox Virus Test Kit is a test kit that can detect orthopox virus. including monkey pox virus Using a technology called quantitative PCR (qPCR), the genetic material in the sample is extracted (Nucleic Acid) and then tested with an assay. with all virus testing kits, reagents and tools It will be distributed by Roche Diagnostics Company.
Currently, it is being used in research studies in many countries.
Currently, Roche Diagnostics Thailand does not have a test kit. and liquids to be sold But in many countries around the world, test kits are being used in research studies. already for Thailand If there is a need to use the test kit for research studies must proceed to the next step.
Proofread by….Suree Silawong
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The team of the Children’s Cancer and Haematological Diseases group at Vall d’Hebrón.
The Vall d’Hebrón Hospital is willing to change the ‘status quo’ linked to pediatric cancer in spainbetting on bringing the precision medicine to patients with relapsed cancer through his participation in the clinical trial European Mappyacts. The research, now completed and published in the journal Cancer Discoveryhas made it possible to demonstrate the benefits of carrying out more extensive studies that characterize the molecular profile of tumors and increase the lit from pediatric population to trials of targeted therapies. Now, the hospital has begun the procedures to participate in the Mappyacts 2which aims to increase the number of predictive biomarkers response with high evidence, enhance the drugs approved targeted products for the pediatric population and generate more clinical trials attached to this population.
Aroa Soriano Fernandezprincipal investigator of the Children’s Cancer and Hematological Diseases group at Vall d’Hebrón, explains in Medical Writing that with this second study “we seek to understand the complexity of many of these pediatric tumors and see what is the best way prioritize in this type of study. Currently open trials for the pediatric population who suffer from cancer are few compared to those carried out to treat this same pathology in adults, so it is “key to have more clinical trials, allowing more patients to benefit from targeted therapies and knowing if survival is increased”.
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“We seek to understand the complexity of many of the pediatric tumors and see what is the best way to prioritize in this type of study” |
Even though he Mappyacts 2 has already started in Francethe country that leads the study and has implemented within its National system of health this type of diagnostic and relapse tests, Vall d’Hebrón is currently carrying out the administrative transactions for your participation. “Since the first study began in 2016, There has been progress, but there is still a long way to go. Of all cancer patients, the 69 percent He received a therapeutic recommendation. Of these patients, only one 10 percent it was with a therapy in which evidence had already been seen that there was a clinical benefit. We must accumulate more certainties for this type of recommendation”, confirms Soriano.
This new research, which will include other European countries and some Spanish hospitals, aims to create international molecular committees to share knowledge and continue to increase access to clinical trials with targeted therapies. In Soriano’s words, “many of the advanced tumors have several relevant oncogenic alterations, highlighting the great complexity of cancer and the need for experienced teams when it comes to prioritize and recommend treatments. Because of this, it is key to design new clinical trials adapted to the degree of complexity of the diseases.
A personalized medicine program of its own in Spain
Another purpose of the international study that Vall d’Hebrón intends to achieve is to continue generating genomic data y knowledge for future research with new treatments. With regard to this section, the specialist states that “at the hospital we were clear that participating in Mappyacts meant learn. Italia y Ireland are the participating countries in addition to spain and sent the samples to France, while here we carried out the sequencing and interpretation of data in the National Center for Genomic Analysis (CNAG), and with them we discussed the results and prioritizations. We wanted to be independent once the study was over and we might startr our own program in Spain, known as Comik. Our next step will be the pencil programwhich seeks to promote personalized medicine in all Spain”.
The liquid biopsy has been a fundamental element in Mappyactsthe first project that has studied its use to analyze the circulating DNA in blood in this population. Now, in this second part of the research, Soriano intends to “expand research projects with their implementation to continue studying molecular alterations.”
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“We wanted to be independent once the study was over and be able to start our own program in Spain” |
Once once more, the multidisciplinary teams have played a key role in regard to these types of programs of precision medicine. As the specialist recalls, “a deep knowledge of the pediatric tumorssu biologythe development of new drugsthe result of the clinical trialsthe availability open clinical trials, as well as other treatment options that may be relevant to the patient. Thus, the discussions between doctors and scientists in the molecular committees of pediatric tumors are crucial in these precision medicine programs”.
The recognition of clinical genetics as a new specialty
The study of genetics has emerged as one of the main protagonists when it comes to carrying out personalized medicine programs, and this new scenario is claimed by Soriano: “These types of personalized medicine programs highlight the need for recognition from Specialty of Clinical Genetics and the recognition of biologists as health professionals by the Ministry of Health”. Precision medicine for pediatric cancer patients advances in Spain, and the next step, the pencil projectis close to being a reality.
Although it may contain statements, data or notes from health institutions or professionals, the information contained in Medical Writing is edited and prepared by journalists. We recommend the reader that any questions related to health be consulted with a health professional.