The European Commission gave the green light in August to the marketing of an HIV treatment in solution for injection twice a year for the treatment of HIV infection, in combination with one or more other antiretrovirals, in infected adults- es by a multidrug-resistant strain of HIV-1 for which it would otherwise be impossible to establish a suppressive antiretroviral therapy regimen. This will be the lenacapavir molecule marketed by Gilead under the name Sunlenca. This molecule is a new capsid inhibitor, a new target of the HIV viral cycle. It has a long half-life and strong antiviral potency. Lenacapavir has no known cross-resistance with other classes of antiretrovirals available and therefore offers a new treatment option, to be administered every six months, to people living with HIV whose virus is no longer effectively controlled by their treatment. It is administered by subcutaneous injection and is currently being tested in several studies in HIV treatment and in Prep. An international team, coordinated by Pr Jean-Michel Molina from the infectious diseases department of Saint-Louis and Lariboisière AP-HP hospitals and Paris Cité University, studied the efficacy and tolerance of lenacapavir in people living with multi-resistant HIV. The results of the Capella study, which demonstrate the very clear efficacy of this treatment in these people, were published in the New England Journal of Medecine May 11, 2022. “Lenacapavir helps meet a critical need for patients with complex treatment histories, and provides physicians with a long-awaited, twice-per-year option for patients who are at greater risk of progress to AIDS,” said Professor Molina. In a press release (August 22), Gilead welcomes this decision: “After more than thirty years of advances in the prevention and treatment of HIV infection, Gilead researchers have made it possible to propose an innovative new option for a long-acting treatment,” said Daniel O’Day of Gilead Sciences. And the laboratory adds: “Lenacapavir is a powerful and unique drug, with the potential for flexible administration. With the approval of the European MA, it is now the first treatment in two administrations per year authorized for people who are fighting once morest multidrug-resistant HIV. Our goal is to offer several long-acting options in the future, in the belief that this will help make a fundamental difference in the journey to end the HIV epidemic”. The Marketing Authorization (MA) applies to the 27 Member States of the European Union, as well as Norway, Iceland and Liechtenstein. Rarely, this European marketing authorization is issued before an American authorization. In July 2022, the US Food & Drug Administration (FDA) accepted for review the New Drug Application (NDA) resubmitted to it for investigational lenacapavir.
Daily Archives
September 7, 2022
See Ice-T and Coco Send Daughter Chanel to 1st Grade in Must-See Pic
written by Alexandra Hartman Editor-in-Chief
And just like that, Ice-T and Coco‘s daughter is off to big kid school.
On Sept. 7, the couple shared photos from Chanel‘s first day of first grade. Before arriving in her classroom, the 6-year-old student posed for a photo, which revealed her pink outfit. She also held up a first day of school sign that confirmed Chanel loves dancing and wants to be a singer when she grows up.
“First Day of School!!” Chanel wrote on her Instagram, which is run by her parents. “I told mommy I know I’m a big girl but I want to stay your baby…Can I be a big girl baby? And she told me no matter what I’m her baby forever.”
Coco described her daughter’s first day of school as “bitter sweet” alongside a photo of Chanel. As for Ice-T, he simply mightn’t believe how quickly life keeps moving.
“Time flies…@BabyChanelWorld,” he wrote on Twitter. “1st day of 1st grade today…How regarding that…Wow.”
Rise in the key rate: “you have to get used to tightening your belt”, fears a trustee in bankruptcy
written by Alexandra Hartman Editor-in-Chief
The increase in the key rate to 3.25% by the Bank of Canada on Wednesday will affect many households that are already having to deal with over-indebtedness and the rise in inflation and the cost of living.
• Read also: The Bank of Canada raises its key rate to 3.25%
“It’s a big pressure, especially since it’s not the first increase we’ve experienced since March. The difference on a mortgage of $320,000 on a monthly payment is regarding $500, it’s considerable,” explained Pierre Fortin, president of Jean Fortin et Associés, trustee in bankruptcy.
In addition to having significant consequences, a greater number of people will be affected.
“Before the pandemic, regarding 25% of mortgage holders had variable rate mortgages. And since the pandemic, because there was a big difference between the fixed and variable rate, more than 50% have opted for a variable rate,” said Pierre Fortin in an interview with TVA Nouvelles.
Owners with a variable rate will see it increase almost immediately, while those with a fixed rate will see the change upon renewal, which can happen within two years.
Pierre Fortin advises these people to start adjusting their spending and budget now, by reducing their discretionary spending.
“We got used to 2%; there, we have just removed an availability of money. […] You have to get used to tightening your belt,” he said.
These increases in spending cause a lot of anxiety, but yet, a few cuts in spending may be enough to relieve households.
“The pandemic has been difficult for everyone. We wanted to spoil ourselves, I think it’s human, I experienced it myself. There may have been a little excess, there was a euphoria that followed this sad and dark period, and there, we see clouds appearing on the horizon, ”imaged Mr. Fortin .
Turkey it will be Saturday at 12 p.m., it’s early but it’s worth it, right?
written by Alexandra Hartman Editor-in-Chief
It was the information everyone was waiting for at the end of the evening. We knew the first four quarter-finals, but to organize the day we needed more, namely to know the time of these four posters. FIBA Bomb has just dropped and the French team will therefore face Turkey at… 12 noon, at the start of a huge day in Berlin.
It’s okay, so you can tell Annabelle and Jérôme that you won’t come to eat in the evening, and also tell them that you won’t come to eat for lunch either. Unless it’s kebab on the menu, so the valve is done and we move on. Because it is therefore at 12 p.m. on Saturday that the French team will play its round of 16, once morest Turkey, a somewhat original schedule but what do you want, no free pass in FIBA, except when you are Slovenian. The full program? Here it is, and we’ll talk regarding it later:
12 p.m.: France – Turkey
2:45 p.m .: Slovenia – Belgium
6 p.m.: Germany – Montenegro
8:45 p.m.: Spain – Lithuania
To make it simple, early morning, obliged, small stretches, breakfast, conditioning, and we will therefore continue on regarding eleven hours of very high level basketball, hoping that the Blues will still put us in a good mood for the rest of the weekend. In the wake of the EDF match, Luka Doncic will take his place to make a good Belgian joke to the Belgians, then the Germans can then count on a crowded arena to push them towards the quarters in a meeting that seems quite within reach once morest Montenegro. Last but not the Lit, the last meeting of the evening will also be the most anticipated by the greatest number, namely a huge clash between La Roja and Lithuaniathe kind of duel that we might very well have found in the semi-finals if Domantas Sabonis had not started his Euro yesterday.
France – Turkey at 12 noon so it’s not the only thing that interests us but let’s say that it will clearly condition our Saturday. And our weekend. And our month of September huh, so ALLEZ LES BLEUS, and as one of the greatest poets of his generation (almost) said very well: “I told you, sir, it’s noon, and at noon bah the bullshit is over »