March 1, 2023

[현대건강신문=여혜숙 기자] An analysis showed that the risk of developing shingles may increase significantly following vaccination with Corona 19. However, it is pointed out that a review of clinical significance is necessary as no significance was found in the analysis by vaccine order.

The National Academy of Medicine of the Republic of Korea (Director Kyu-Chang Wang), established with the goal of evaluating the causality of adverse events following vaccination with the Corona 19 vaccine, held the 3rd forum on the 28th following the 1st and 2nd forums. .

In this forum, research analysis on the association between COVID-19 vaccination and deep vein thrombosis (without thrombocytopenia), pulmonary embolism, shingles, and multiple sclerosis was explained.

First, as a result of confirming the association between corona 19 vaccination and ‘deep vein thrombosis (without thrombocytopenia) and pulmonary embolism’, it was difficult to confirm causality.

Gachon University Gil Hospital Professor Jeong Jae-hoon of the department of infectious medicine said, “There is no evidence to support causality in deep vein thrombosis in the previous analysis. Therefore, in this reanalysis, we evaluated the statistical relevance of domestic COVID-19 vaccination and deep vein thrombosis and pulmonary embolism by utilizing strict case definitions and two independent research methodologies.” An increase in the incidence of deep vein thrombosis and pulmonary embolism was not observed. This is consistent with the results of a number of studies conducted overseas and a meta-analysis that synthesized them.”

The association between vaccination once morest Corona 19 and the occurrence of shingles can be somewhat increased, but additional research is needed.

Cases of shingles following diagnosis of COVID-19 and cases of reactivation of the shingles virus following vaccination with COVID-19 were reported around the world, and it was necessary to conduct epidemiological analysis to determine the safety of vaccines according to the number of vaccines and vaccine types in Korea. .

To evaluate the association between the COVID-19 vaccine and herpes zoster, we checked the incidence of herpes zoster in Korea for regarding 10 years, and compared the expected and observed incidence rates of herpes zoster following vaccination with the COVID-19 vaccine.

In addition, using the Self-Controlled Case Series (SCCS) design, the ‘risk interval (1–28 days following vaccination)’ and In the event of shingles, the ‘control period (period excluding the risk period within the observation period)’, which is expected to be unrelated to the vaccine, was compared.

Professor Sohn Hyo-joo of the Department of Infectious Diseases at Uijeongbu Eulji University Hospital said, “As a result of the study, the crude incidence rate per 100,000 population has been continuously increasing since 2013, with 1164.1 in 2020 and 1211.2 in 2021. As a result of the SCCS analysis, the risk of developing shingles within 28 days following vaccination was found to increase significantly by 1.1 times.”

However, he explained that there was no significance in the analysis of each vaccine sequence, so it is necessary to review the clinical significance.

Professor Sohn said, “A significant increase in risk was observed in age groups and chronic disease companions in the small group analysis, indicating the need to manage risk factors for common shingles.” is needed,” he said.

Due to the lack of safety evidence for the relationship between COVID-19 vaccination and multiple sclerosis, an epidemiological analysis was performed on the risk of multiple sclerosis following vaccination in the entire population of Korea.

A self-control study design was applied to evaluate the association between COVID-19 vaccine and multiple sclerosis. When the observation period was 270 days following vaccination with COVID-19 vaccine and the risk interval was set as 1 to 30 days or 1 to 60 days following vaccination, the risk of occurrence was 0.91 and 0.71 times, respectively, compared to the control group, but statistically significant. Did not do it.

Even when sensitivity analysis was performed with various operational definitions of patients with multiple sclerosis, no increase in the risk of multiple sclerosis was observed following vaccination with the COVID-19 vaccine. There was no statistical significance in the results of subgroup analysis according to gender, age, type of vaccine recently received before onset, and comorbidity score.

Professor Kim Yoo-hwan of the Department of Neurology at Hallym University Sacred Heart Hospital said, “Considering the results of this study and the review of literature, the scientific evidence to date has been evaluated as insufficient to admit or deny the causality between the COVID-19 vaccine and multiple sclerosis. “he said.

“At this forum, we presented research and analysis results related to deep vein thrombosis, herpes zoster, and multiple sclerosis, which are of high interest to the public,” said Park Byeong-joo, head of the COVID-19 Vaccine Safety Research Center. showed that vaccination with Corona 19 did not increase the risk of occurrence, and shingles appeared to slightly increase the risk of occurrence, but additional research is needed for clinical significance.”

In addition, “I deeply sympathize with the pain and frustration of those who have suffered from adverse reactions since the corona 19 vaccine, and I especially offer deep consolation to those who have died and their families. We will continue to make efforts to make more accurate results in terms of scientific causality through continuous research on various diseases.”

Brazilian Gabriel Menino, Palmeiras midfielder, has become the talk of the international press following confirming that he tried to follow the diet of Portuguese star Cristiano Ronaldo, which endangered his life.

In statements to the Brazilian “Palmeiras Cast” platform, which was widely reported by the international press, Menino revealed that he wanted to try Cristiano’s diet to be a basic option for the coach of the Brazilian football giant.

“I wanted to be like Cristiano Ronaldo, because in the 2020-2021 season I was the third choice for Portuguese coach Abel Ferreira,” Menino, 22, said in his statements. And the player added in his statements: “I tried Ronaldo’s diet: an egg and nutritional supplements for breakfast, and other supplements before exercise, in the followingnoon and before bed as well, and then grilled fish or meat and salad for lunch and dinner.”

Crisis on match day

The next day, the player was called up for the match and immediately noticed the effect, and regarding this he said: “I was warming up and the only thing I might see was that I was going to die. Five minutes into the match I mightn’t keep running.”

Also, according to the player’s statements, fortunately one of his teammates was being treated by a specialized doctor, as he took advantage of a break between halftime to receive treatment.

Menino is currently playing a key role in the ranks of his Palmeiras team, with whom he won the Libertadores Cup and the Brazilian League Championship, in addition to other titles.

Cristiano Ronaldo, 38, a player for the Saudi Al-Nasr club, is considered one of the most enthusiastic players to follow a healthy diet and lifestyle, so that during Euro 2020, he removed a bottle of “Coca-Cola” from the press conference table and said, “Drink water.”