Innovative Therapy Revolutionizes Treatment for Peyronie’s Disease in Urology

New Hyaluronic Acid Treatment Approved for Peyronie’s Disease in Italy

October 10, 2025

A groundbreaking new treatment utilizing hyaluronic acid has received approval in Italy for the acute phase of Peyronie’s Disease, a frequently misunderstood condition impacting penile health. This progress marks a important advancement in managing a disorder that can cause pain, curvature, and erectile dysfunction.

Understanding Peyronie’s Disease

Peyronie’s Disease is characterized by the formation of fibrous plaques within the tunica albuginea, the protective tissue surrounding the penis. These plaques reduce tissue elasticity, possibly leading to a curved or shortened penis and, in many cases, painful erections. prevalence rates vary, affecting between 0.7% and 11% of adult men,with a peak incidence between the ages of 50 and 60.Recent Italian studies estimate a prevalence of 7.1% among men aged 50-70, while some analyses suggest a rate between 1.5% and 16.9% in those under 40.

A significant challenge in accurately assessing the extent of Peyronie’s Disease lies in underreporting, as embarrassment and societal stigma often prevent individuals from seeking medical attention.

A New Therapeutic Approach

The newly approved treatment involves intraplaque injections of ultrapure hyaluronic acid, administered in weekly cycles of 10 to 12 weeks. The aim is to reduce the size and rigidity of the fibrous plaques, promoting natural tissue healing. This represents the first hyaluronic acid-based therapy available in Italy for this condition.

The Pathology and its Impact

“This is a chronic, acquired condition that can be truly debilitating,” explains Andrea Salonia, a Full Professor of Urology at the Vita-Salute San Raffaele University in Milan. “Pain can occur even when not erect, yet data remains limited due to patient reluctance to discuss the issue. Currently, there is a lack of specialized centers dedicated to this condition.”

Luca Boeri, a Urologist and Andrologist at the IRCCS Ca’ Granda Foundation Ospedale Maggiore policlinico of Milan, notes the uncertain etiology of the disease, suggesting a potential genetic component alongside inflammatory triggers that typically manifest with age. The inflammatory phase typically lasts up to twelve months, transitioning into a chronic phase characterized by penile curvature.

Lifestyle factors, such as smoking, type 1 diabetes, psoriasis, vitiligo, and hypertension, are also frequently associated with the onset of Peyronie’s Disease.

The Importance of Holistic Care

Beyond medical intervention,psychological support is essential. “The psychologist’s intervention is crucial, focusing on strengthening self-esteem, reframing beliefs about sexuality, and managing performance anxiety,” states Sabina Fasoli, a psychotherapist and clinical sexologist. “It’s vital to help patients understand that their self-worth extends beyond sexual performance.”

Gianmarco Rea, Secretary of Simg Lazio region, emphasizes the initial role of general practitioners in recognizing and addressing the condition. He highlights the need for increased training for GPs to improve diagnosis and facilitate referrals to specialists. “General Practitioners often lack thorough training in Peyronie’s Disease, hindering early detection and appropriate care.”

Peyronie’s Disease: Key Statistics

Statistic	Data
Global Prevalence (Adult Men)	0.7% – 11%
Italian Prevalence (50-70 age group)	7.1%
Italian Prevalence (Under 40)	1.5% – 16.9%
Typical Age of Onset	50-60 years

Did You Know? While often associated with older men, Peyronie’s Disease can affect individuals of any age, highlighting the importance of early diagnosis and treatment regardless of age.

Pro Tip: Open dialog with your healthcare provider is paramount. Don’t let embarrassment prevent you from discussing any concerns about your sexual health.

Frequently Asked Questions about Peyronie’s Disease

• what is Peyronie’s Disease? Peyronie’s Disease is a condition resulting in the formation of fibrous plaques in the penis, leading to curvature and potential pain.
• What causes Peyronie’s Disease? The exact cause is unknown, but genetic predisposition and inflammatory processes are believed to play a role.
• is Peyronie’s Disease curable? While there isn’t a definitive cure, new treatments like hyaluronic acid injections aim to reduce symptoms and improve quality of life.
• What are the symptoms of Peyronie’s Disease? Symptoms include penile curvature, pain during erection, and difficulty with sexual intercourse.
• Should I see a doctor if I suspect I have Peyronie’s Disease? Yes, early diagnosis and treatment are essential for managing the condition and preventing further complications.
• Are there any lifestyle changes that can definitely help with Peyronie’s Disease? Avoiding smoking and managing underlying health conditions like diabetes can be beneficial.
• What role does psychological support play in treating Peyronie’s Disease? Psychological support helps address emotional distress, anxiety, and self-esteem issues frequently enough associated with the condition.

What are your thoughts on this new treatment option? Share your comments below!

What are the current limitations of traditional Peyronie’s disease treatments like oral medications and surgery?

Understanding Peyronie’s Disease: Beyond the Bend

Peyronie’s disease, a condition affecting men, is characterized by the development of fibrous scar tissue inside the penis. This can lead to painful erections, curvature, and difficulties with sexual intercourse. Traditionally, treatment options have been limited, often focusing on managing symptoms rather than addressing the underlying cause. However, a new wave of innovative therapies is changing the landscape of peyronie’s disease treatment, offering hope for improved outcomes and quality of life.Keywords: Peyronie’s disease, penile curvature, erectile dysfunction, urology, scar tissue.

The Evolution of Peyronie’s Disease Therapies

for years, the approach to peyronie’s disease was largely conservative.This included:

* Observation: Monitoring the condition, notably in the early inflammatory phase.

* Oral Medications: Vitamin E, potassium aminobenzoate (Potaba), and colchicine where commonly prescribed, though their efficacy has been debated.

* Injection Therapies: Collagenase clostridium histolyticum (Xiaflex) became a important advancement, approved by the FDA for treating penile curvature.

* Surgical Intervention: Penile plication, grafting, or incision were reserved for severe cases after the disease had stabilized.

However, these methods often came with limitations – side effects, inconsistent results, or the need for invasive procedures. The current revolution centers around therapies targeting the inflammatory and fibrotic processes at a molecular level. keywords: Peyronie’s treatment options, Xiaflex, penile surgery, conservative treatment.

Xiaflex®: A Breakthrough in Non-Surgical Treatment

Collagenase clostridium histolyticum (Xiaflex) represents a major step forward. It’s an injectable enzyme that breaks down the collagen in the plaque, aiming to reduce curvature.

* How it Works: Xiaflex is administered via multiple injections into the plaque. A specific protocol involving penile modeling exercises is crucial for maximizing results.

* Efficacy: Clinical trials have demonstrated significant improvements in penile curvature in many patients.

* Considerations: Xiaflex is not a cure, and repeat treatments might potentially be necessary. Potential side effects include pain, swelling, and bruising. It’s vital to be treated by a qualified urologist experienced in Xiaflex governance. Keywords: Xiaflex injection, collagenase clostridium histolyticum, penile modeling, Peyronie’s disease injection.

Emerging Therapies: Targeting Inflammation and Fibrosis

Beyond Xiaflex, research is actively exploring several promising new avenues:

1. Low-Intensity Extracorporeal Shockwave Therapy (Li-ESWT)

Li-ESWT utilizes acoustic waves to stimulate tissue repair and reduce inflammation. While still considered investigational for peyronie’s disease, early studies suggest it may:

* Reduce pain.

* Improve erectile function.

* Potentially decrease plaque size.

2. Platelet-Rich Plasma (PRP) Therapy

PRP involves injecting a concentration of the patient’s own platelets into the plaque. Platelets contain growth factors that promote healing and tissue regeneration. PRP is being investigated for its potential to:

* Reduce inflammation.

* Break down scar tissue.

* Improve penile hemodynamics.

3. Verapamil and Other Anti-Fibrotic Agents

Research continues on the use of medications like verapamil, initially developed for heart conditions, to inhibit collagen production. Other anti-fibrotic agents are also under investigation. Keywords: Li-ESWT, shockwave therapy, PRP therapy, platelet-rich plasma, verapamil, anti-fibrotic drugs.

The Role of Early Diagnosis and Intervention

Early diagnosis is crucial for optimal treatment outcomes. Men experiencing penile curvature, pain during erections, or difficulty with intercourse should consult a urologist promptly.

* Diagnostic Tools: Physical examination, patient history, and sometimes imaging studies (penile ultrasound) are used to diagnose Peyronie’s disease.

* Treatment Timing: Intervention during the acute inflammatory phase (typically within 6-12 months of symptom onset) may be more effective in preventing the progression of fibrosis. Keywords: Peyronie’s diagnosis,penile ultrasound,early intervention,urological evaluation.

Benefits of Innovative Therapies

The shift towards innovative therapies offers several potential benefits for men with Peyronie’s disease:

* Reduced Need for Surgery: Non-invasive or minimally invasive options may delay or eliminate the need for surgical correction.

* Improved Erectile Function: Some therapies aim to improve blood flow and erectile capabilities.

* Enhanced Quality of Life: Reducing pain, curvature, and sexual dysfunction can significantly improve a man’s overall well-being.

* Targeted Treatment: New therapies focus on addressing the underlying disease mechanisms, rather than just managing symptoms. Keywords: quality of life, erectile function, non-surgical treatment, Peyronie’s disease benefits.

Practical Tips for Managing Peyronie’s Disease

Alongside medical treatment, these steps can help manage symptoms:

* **Penile Stretching Exercises