A possible advance in medicine to face the advance of dengue

It would seem today too much to worry as a society about another disease that is not that of the coronavirus, but it happens that in the country and in our area dengue cases do not stop growing.

The health data leaves no room for doubts in this regard, according to what health organizations and specialists on the subject came to know. The sources also highlighted that the magnitude of the dengue epidemic worldwide is closely related to the conditions that favor the survival of the mosquito.

In this context, the conquest achieved by Conicet scientists who, as reported in recent editions, managed to describe a key mechanism of the maturation process of dengue and Zika viruses in the interior of cells, which could be used to develop treatments that prevent the multiplication of viruses in the body.

“Our discovery allows us to think about the design of possible antiviral therapies against dengue and Zika based on obtaining molecules that can somehow counteract the process that we were able to describe and thus interrupt viral replication,” explained one of the leaders. of the study and researcher of the Center for Research in Biological Chemistry of Córdoba (Ciquibic), which depends on the Conicet.

It should be noted that in 2019, the Pan American Health Organization (PAHO) reported more than 3 million cases of dengue in Latin America, the highest number recorded in history for the region; And as for Zika, although after the epidemic outbreak in America in 2016-2017 it declined significantly, the consequences it left are still being studied and it cannot be ruled out that it will emerge again.

The study by the Conicet scientists, published in “The Journal of Biological Chemistry”, found that “the capsid proteins (protective shield) of dengue and Zika viruses are capable of binding lipid membranes and viral RNA in the same coordinated event forming a new phase known as ‘liquid droplets’, they explained.

Dengue is the result of a viral infection transmitted by the bite of infected female mosquitoes of the genus Aedes aegypti and there are four serotypes of the virus. In Argentina there are three: the DEN-1, the DEN-4 and the DEN-2. Now specialists are warning that the mosquito has adapted and can resist lower temperatures, so they ask not to loosen with preventive measures – such as discarding – even during winter.

It is also known that each insect can bite an infected person and in the next bite transmit the dengue virus to another, they explained. Symptoms are headaches, muscle aches, behind the eyes, and general decay. Patients require “immediate medical attention and isolation, because while they are sick they can be a source of contagion,” they warned. It was emphasized that, if not treated in a timely manner, dengue can lead to the death of the affected person.

It is clear that most health efforts today are focused on the prevention of COVID-19 infections and that, therefore, the reality of dengue and Zika appears as masked, even when specialists insist that it is extremely dangerous. The progress mentioned here constitutes, therefore, a scientific alternative that can give positive answers to these evils.


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