2023-12-12 23:36:49

Biologiste365 – Cardiovascular diseases: the role of the intestinal microbiota explored

Eating less fat and more fiber helps limit the risk of developing cardiovascular disease. If this statement has become a commonplace, what is less common are the mechanisms involved in the development of diseases such as atherosclerosis. This is why researchers from Inserm and Paris Cité University looked into the subject. They therefore worked on the influence of a fatty and low-fiber diet on the intestinal microbiota of mice and on how the latter might contribute to the development of atherosclerosis.

An intestinal but also cardiovascular risk

Indeed, this work, published in the scientific journal Cell Reports, show that the low fiber content of the fatty diet would lead to an imbalance in the microbiota, itself the cause of systemic inflammation aggravating the development of atherosclerotic plaques in the arteries. Result, apart from the risks of intestinal disorders, an unbalanced diet has indeed shown in mice an increase in metabolic risk factors linked to cardiovascular diseases*. But that’s not all, the researchers also noted that this imbalance in the microbiota is also manifested by an alteration in the production of metabolic derivatives by the bacteria that compose it.

* Weight gain, high blood sugar, insulin resistance, increased liver weight, etc.

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