2024-02-26 08:45:34
From the start, the two teams remained wheel in wheel (24-24; 13th) but the locals, imperial at 3 points (8 successful out of 10 attempted) took the lead at the break (49-39). On returning from the locker room, the Ile-de-France residents, always in full swing and above all with impressive skill (more than 75% shooting success) outclassed their borrowed and sometimes resigned opponents (80-50; 30th). The Do…
1708961915
#Basketball #Dourges #submerged #Gennevilliers
London, Feb 26 (EFE).- The British Minister of Foreign Affairs, David Cameron, will attend this Monday the conference organized by the President of France, Emmanuel Macron, to reaffirm support for Kiev, a Foreign Office spokesperson confirmed to Efe. .
“The event aims to redouble our support to ensure Ukraine wins as we approach the third year of (Russian President Vladimir) Putin’s illegal war,” the source said.
“Together with the French we will demonstrate the strength of unity once morest Russian aggression,” the spokesman said.
On the occasion of the second anniversary of the invasion of Ukraine, the British Prime Minister, the conservative Rishi Sunak, on Sunday called on Ukraine’s allies to be “bolder” to seize Russian assets frozen in different countries and use them to support the Ukrainian troops.
By: EFE
The post Cameron will attend the Paris conference to express support for Ukraine appeared first on Minuto30.
2024-02-26 15:21:21
#Cameron #attend #Paris #conference #express #support #Ukraine
:quality(85)/cloudfront-us-east-1.images.arcpublishing.com/infobae/YPZL2UUZHZHMHICZJ5USZ35OII.jpg)
2024-02-26 13:10:00
This screenshot from a video taken on February 22, 2024, shows Afghan men leaving a football stadium following attending the public execution by Taliban authorities of two men convicted of murder, in Ghazni. (AFP)
The Taliban on Monday carried out the public execution of a man convicted of murder in northern Afghanistan before thousands of people at a sports stadium, the third such death sentence carried out in the last five days.
You may be interested in: Who is the Mexican Iván Cantú and why was he sentenced to the death penalty in Texas
The execution took place with great spectacle in the city of Shibirghan, capital of the northern province of Jawzjan, where the brother of the murdered man shot the prisoner five times with a rifle, according to an eyewitness. Security around the stadium was tight, said the witness, who spoke on condition of anonymity because he was not authorized to speak to the media.
It was also the fifth public execution since the Taliban took power in Afghanistan in August 2021, when US and NATO troops were in the final weeks of their withdrawal from the country following two decades of war.
You may be interested in: China: following 5 years of sustained torture, the writer sentenced to death decided not to appeal his sentence
The event was ominous as the Taliban, despite initial promises of a more moderate government, began carrying out severe public punishments (executions, floggings and stonings) shortly following coming to power, applying the “eye for an eye” rule. ”, which rewards the criminal with the same damage caused. The punishments are similar to those meted out under Afghanistan’s previous government in the late 1990s.
Taliban government officials were not immediately available for comment.
The United Nations has sharply criticized the Taliban for carrying out public executions. Europa Press/Contact/Saifurahman Safi
The statement said Monday’s death sentence was carried out following approval by three of the country’s highest courts and Taliban supreme leader Mullah Haibatullah Akhundzada. The executed man, identified as Nazar Mohammad from Bilcheragh district in Faryab province, had killed Khal Mohammad, also from Faryab. The murder took place in Jawzjan.
You may be interested in: Why can’t the death penalty be applied in Peru to fight crime?
On Thursday, in the southeastern province of Ghazni, the Taliban executed two men convicted of stabbing their victims to death. He identified them as Syed Jamal, from the central province of Wardak, and Gul Khan, from Ghazni, although it was not clear who carried out the stabbings, the two convicted men or others.
The statement also said that three lower courts and the Taliban’s supreme leader, Hibatullah Akhundzada, had ordered the executions in retaliation for their alleged crimes. The victims’ relatives shot the two men, also in a sports stadium while thousands of people watched.
Separate statements from the Taliban supreme court said a man and woman convicted of adultery were lashed with 35 lashes each in the northern province of Balkh over the weekend. Two other people were flogged in the eastern province of Laghman, also over the weekend; each received 30 lashes for allegedly committing immoral acts.
The United Nations has sharply criticized the Taliban for carrying out public executions, floggings and stonings since they took power, and has called on the country’s rulers to end such practices.
(with information from AP)
1708959442
#Taliban #carried #public #execution #thousands #people #stadium #northern #Afghanistan
2024-02-26 14:46:08
Key message:
In this phase II trial, individuals with moderate to severe plaque psoriasis were randomly assigned to receive JNJ-77242113, an IL-23 receptor antagonist peptide, at various doses or a placebo for 16 weeks. Results demonstrated a higher percentage of patients achieving a PASI 75 response at week 16 in the JNJ-77242113 groups (ranging from 37% to 79%) compared to the placebo group (9%), with a Remarkable and statistically significant dose-response. Adverse events, most commonly COVID-19 and nasopharyngitis, occurred at a similar rate between the combined JNJ-77242113 dose group and the placebo group.
Summary:
Background
The use of monoclonal antibodies has changed the treatment of several immune-mediated inflammatory diseases, including psoriasis. However, these large proteins must be administered by injection. JNJ-77242113 is a novel, orally administered interleukin-23 receptor antagonist peptide that selectively blocks interleukin-23 signaling and downstream cytokine production.
Methods
In this phase 2 trial to find the appropriate dose, we randomly assigned patients with moderate to severe plaque psoriasis to receive JNJ-77242113 at a dose of 25 mg once daily, 25 mg twice daily, 50 mg once once a day, 100 mg once a day, or 100 mg twice a day, or a placebo for 16 weeks. The primary endpoint was a reduction of at least 75% from baseline on the Psoriasis Area and Severity Index (PASI) (PASI response 75; PASI scores range from 0 to 72, with higher scores indicating greater extent or severity of psoriasis) at week 16.
Results
A total of 255 patients underwent randomization. The mean PASI score at baseline was 19.1. The median duration of psoriasis was 18.2 years, and 78% of patients in all trial arms had previously received systemic treatments. At week 16, the percentages of patients with a PASI 75 response were highest among those in the JNJ-77242113 groups (37%, 51%, 58%, 65%, and 79% in the 25 mg once daily groups). day, 25 mg twice daily, 50 mg once daily, 100 mg once daily, and 100 mg twice daily, respectively) than among those in the placebo group (9%), a finding that showed a significant dose-response relationship (P<0.001). The most common adverse events included coronavirus disease 2019 (in 12% of patients in the placebo group and in 11% of those in the JNJ-77242113 dose groups) and nasopharyngitis (in 5% and 7% of those in the JNJ-77242113 dose groups). %, respectively). The percentages of patients who had at least one adverse event were similar in the combined JNJ-77242113 dose group (52%) and in the placebo group (51%). There was no evidence of a dose-related increase in adverse events in the JNJ-77242113 dose groups.
Conclusions
After 16 weeks of oral administration once or twice daily, treatment with the interleukin-23 receptor antagonist peptide JNJ-77242113 showed greater efficacy than placebo in patients with moderate to severe plaque psoriasis.
Fuente: BioPress
1708959376
#oral #interleukin23 #receptor #antagonist #peptide #plaque #psoriasis
