Health

A delayed hypersensitivity reaction known as fixed drug eruption (FDE) can manifest as recurring skin lesions at the same location each time an offending medication is ingested. While often associated with antibiotics like cotrimoxazole and amoxicillin, cases linked to ciprofloxacin and metronidazole, frequently used in treating infections, are increasingly being reported. Understanding the presentation and potential for these reactions is crucial for timely diagnosis and management.

FDE is characterized by the appearance of distinct, often reddish, lesions that reappear at the same site on the skin with each subsequent exposure to the triggering drug. The lesions can vary in appearance, ranging from red patches to blisters and may be accompanied by itching. While typically localized, generalized forms of FDE, though less common, can occur, as highlighted in recent case studies. The delayed nature of the reaction – appearing hours or even days after drug administration – can sometimes craft identifying the causative agent challenging.

Recent reports detail instances where concurrent use of ciprofloxacin and metronidazole led to the development of FDE. One case, documented in research, involved a 40-year-old female who developed blackish, hyperpigmented skin lesions across her body, along with fluid-filled lesions on her arms and legs, following intravenous administration of both ciprofloxacin and metronidazole for acute infective diarrhea and vomiting. The patient’s condition improved after discontinuing the medications and receiving symptomatic treatment, including antihistamines and corticosteroids.

Dermoscopy, a non-invasive skin surface microscopy technique, can be a valuable tool in aiding the diagnosis of FDE. While clinical presentation is often suggestive, dermoscopic features can help differentiate FDE from other skin conditions with similar appearances. The use of dermoscopy can assist clinicians in making a more accurate and timely diagnosis, leading to prompt discontinuation of the offending drug and appropriate patient management.

Ciprofloxacin, a fluoroquinolone antibiotic, is commonly prescribed for a variety of bacterial infections. Metronidazole, an antimicrobial and antiprotozoal medication, is frequently used to treat anaerobic bacterial and parasitic infections. The combination of these drugs is sometimes employed for conditions like severe diarrhea. However, as demonstrated by reported cases, their concurrent use carries a risk of triggering FDE in susceptible individuals. According to a 2018 report, antibiotics are implicated in 1–2% of cutaneous adverse reactions.

The mechanism behind FDE is believed to involve a delayed-type hypersensitivity reaction. In other words the immune system reacts to the drug or its metabolites, leading to inflammation and skin lesions at the site of contact. Repeated exposure to the drug amplifies this response, resulting in the characteristic recurrence of lesions in the same location. Other antibiotics, including doxycycline, tetracycline, and norfloxacin, have also been associated with FDE, as noted in a study published in the BMJ Case Reports journal in 2018.

Diagnosis typically relies on a thorough medical history, including a detailed medication list, and a clinical examination of the skin lesions. A drug provocation test, where the patient is cautiously re-exposed to the suspected drug under medical supervision, can sometimes be used to confirm the diagnosis, but this carries risks and is not always necessary. Avoiding the offending drug is the primary treatment for FDE, and symptoms usually resolve within a few days to weeks after discontinuation.

While FDE is generally not life-threatening, it can cause significant discomfort and distress to affected individuals. Raising awareness among healthcare professionals and patients about the potential for this reaction, particularly with commonly used medications like ciprofloxacin and metronidazole, is essential for early detection and appropriate management. Further research is needed to better understand the underlying mechanisms of FDE and identify individuals at higher risk.

The increasing recognition of FDE associated with ciprofloxacin and metronidazole highlights the importance of careful medication review and patient monitoring. Clinicians should consider the possibility of FDE in patients presenting with unexplained skin lesions, especially those with a history of recent antibiotic use. Continued vigilance and reporting of adverse drug reactions are crucial for improving patient safety and optimizing treatment strategies.

Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Have you or someone you realize experienced a similar reaction to antibiotics? Share your thoughts and experiences in the comments below.

Pontacq football club has been active both on and off the pitch, with recent activities ranging from youth development workshops to competitive matches. A focus on player well-being was evident with a nutrition workshop for young athletes, while the senior teams faced challenges in cup competitions and league play. These developments highlight the club’s commitment to holistic development and competitive spirit within the Pyrénées-Atlantiques region.

The club recently hosted a workshop titled “La nutrition du petit sportif” (Nutrition for the Young Athlete), led by Florence and Anaïs from JFG CLINIC Tarbes Garcia Thomas. This initiative underscores the growing recognition of the importance of nutrition in youth sports performance and overall health. The workshop aimed to educate young players and their parents on optimal dietary practices to support athletic development. JFG CLINIC Tarbes Garcia Thomas is a specialized clinic focused on sports medicine and nutrition, indicating a professional approach to player care within the Pontacq club.

On the field, the Pontacq senior team competed in a Coupe Fuma quarter-final match against Espoey, unfortunately resulting in a 3-1 loss. Despite the defeat, the team reportedly celebrated the “third half” – a tradition of post-match camaraderie – with a positive outlook, anticipating the upcoming France-Italy match. This demonstrates a strong team spirit even in the face of setbacks.

Beyond the senior squad, the club’s youth teams were likewise in action. U13F and Seniors F teams participated in a joint indoor football session followed by a shared meal, fostering team bonding and a sense of community. This type of activity is crucial for developing social skills and teamwork alongside athletic abilities.

Several youth matches took place on February 7, 2026, as detailed on the club’s official calendar. The U10/U11 teams faced ASPTT DE PAU, while the U9 team competed against F. C. DES ENCLAVES ET DU PLATEAU. Another U10/U11 team played against U. JURANCONNAISE. These matches provide valuable competitive experience for developing players.

The senior team also saw action on February 7th, competing in a Departmental 4 match against ARUDY U.S.M21, resulting in a 3-1 loss. A Seniors à 7 team played against OLORON BEARN FC61 on February 8th, and the U.S. JURANCONNAISE U. 240 team faced Pontacq Papillons in a Departmental 2 match on the same day. These games showcase the breadth of football activity within the club.

Recent match results for the U11 teams included a victory against FC La Ribere and Esman, as well as Vallée de l’Ousse, while a defeat was recorded against Taron. The U13 Élite team, Papillons des Enclaves, achieved a decisive 5-1 win against Bleuets de Pau, with Yanis scoring twice, alongside goals from Ardennes, Edan, and Quentin. The U13 B team secured a 3-0 victory over Fameb, with Nathan scoring twice and Erwan adding a goal. The U15 team drew 2-2 against Genets d’Anglet, with Maxence and Théo finding the net. Notably, the U17 team achieved a significant 5-0 victory against Ustaritz, with goals from Amaury, Iban, Evan, Loïc, and Tiago, a particularly impressive result against the Division 1 league leaders.

The Senior A team drew 2-2 against Pau Portugais, securing a point in a hard-fought match. The club’s calendar indicates a postponed match for the Seniors Departmental 2 team against ENCLAVES DU PLATEAU on February 21st, and a postponed match for the Seniors Departmental 4 team against GANTOIS FC on February 22nd. A Coupe Fuma Seniors à 7 quarter-final match against FCVO31 took place on February 22nd.

Looking ahead, the club has several matches scheduled for the complete of February, including U13 D4 and Seniors Departmental 2 games. The continued participation of youth and senior teams in various leagues and competitions demonstrates the Pontacq football club’s active role in the local sporting community. The club’s commitment to both athletic performance and player well-being, as evidenced by the nutrition workshop, positions it as a positive force in youth development and community engagement.

The Pontacq football club continues to be a vibrant hub for sporting activity in the region. Further updates on match results, club events, and youth development initiatives can be expected as the season progresses. We encourage readers to share their thoughts and experiences with the club in the comments below.

Disclaimer: This article provides informational content about sporting events and club activities. It is not intended to provide medical or athletic training advice.