Health

A significant setback for early cancer detection has emerged as Grail, a U.S. Biotech company backed by Samsung, announced disappointing results from a large-scale clinical trial of its “Gallery” test in the United Kingdom. The trial, designed to assess the test’s ability to detect cancer at earlier stages, failed to meet its primary endpoint, sending the company’s stock price plummeting over 50% in a single day. The outcome casts a shadow over Grail’s plans to gain regulatory approval and widespread insurance coverage for the potentially groundbreaking blood test.

Grail’s Gallery test analyzes blood samples for minute traces of cancer DNA, aiming to detect over 50 different types of cancer in their early stages – even before symptoms appear. While the test has been commercially available in the United States since 2021, with nearly 500,000 tests administered to date, including 185,000 in the past year, it currently lacks approval from the U.S. Food and Drug Administration (FDA) and is rarely covered by insurance. The promise of broader access hinged on demonstrating the test’s clinical and economic value, a goal now complicated by the UK trial results.

The primary endpoint of the UK trial focused on assessing the test’s impact on the proportion of patients diagnosed with stage 3 or 4 cancer. Grail had hoped to demonstrate that early detection through Gallery would shift diagnoses towards earlier stages (1 and 2), reducing the prevalence of late-stage cancers. However, in a statement released after market close, the company acknowledged that this primary endpoint was “not observed.” Despite this, Grail representatives suggested during an investor call that the test may still have a modest effect on advancing the timing of cancer diagnoses, with some positive trends observed in secondary endpoints such as a potential reduction in stage 4 diagnoses and an increase in stage 3 diagnoses.

The trial involved 142,000 participants aged 50 to 77. The disappointing results come at a critical juncture for Grail, as the company had anticipated benefiting from a recent U.S. Federal spending package that includes a provision allowing Medicare, the public health insurance program for seniors and individuals with disabilities, to cover cancer diagnostic tests. This provision, signed into law by President Trump in February, raised hopes that Gallery could develop into a covered benefit. However, the UK trial failure has significantly dampened those expectations.

Samsung’s Investment and Future Implications

Grail’s stock price reflected the market’s reaction to the news, closing down 50.55% at $50.21 on February 20th, 2026, and continuing to fall in after-hours trading, dropping below the $50 mark. The company has significant ties to Samsung, with Samsung Electronics and Samsung C&T investing $110 million (approximately 159 billion Korean won) in Grail in October 2025. At the time, Samsung C&T secured exclusive rights to distribute Gallery in South Korea, with plans to expand collaboration into Singapore and Japan. Samsung Electronics also expressed interest in integrating Grail’s genomic data with its Samsung Health platform to offer innovative health management experiences to users. Source: Nate News

The failed trial raises questions about the future of multi-cancer early detection tests and the viability of Grail’s business model. While the company maintains that Gallery shows promise, the lack of a clear signal in the primary endpoint will likely require further research and refinement. The path to regulatory approval and widespread adoption now appears more challenging, and the impact on Samsung’s investment remains to be seen.

The development of effective early cancer detection methods remains a critical area of medical research. The potential to identify cancers at earlier, more treatable stages could significantly improve patient outcomes and reduce healthcare costs. However, as the Grail experience demonstrates, translating promising scientific concepts into clinically validated and commercially successful products is a complex and often unpredictable process.

Disclaimer: This article provides informational content about medical research and is not intended to be a substitute for professional medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment of any medical condition.

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A strong core is often associated with visible abs and athletic performance, but its benefits extend far beyond aesthetics. Crucially, core strength plays a vital role in pelvic floor health, impacting everything from bladder control to sexual function and overall well-being. Many people are unaware of the deep connection between these muscle groups, and strengthening the pelvic floor often requires a nuanced approach.

Pelvic floor dysfunction affects millions, manifesting as incontinence, pelvic pain, and difficulties with sexual intimacy. While specialized pelvic floor physical therapy is often the gold standard for treatment, incorporating targeted core exercises into a regular routine can be a powerful preventative measure and supportive therapy. Dr. Heather Jeffcoat, a Doctor of Physical Therapy and founder of Femina Physical Therapy and Fusion Wellness &amp. Physical Therapy, emphasizes the importance of a holistic approach to pelvic health, recognizing the integral role of core stability. Jeffcoat, author of Sex Without Pain: A Self-Treatment Guide to the Sex Life You Deserve, has dedicated over 20 years to helping patients regain control and comfort through targeted physical therapy.

Understanding the Core-Pelvic Floor Connection

The pelvic floor isn’t an isolated set of muscles; it works in coordination with the deep core muscles – the transversus abdominis, diaphragm, and multifidus – to provide stability and support. These muscles act like a natural corset, supporting the spine, internal organs, and contributing to proper movement patterns. When the core is weak, the pelvic floor has to work harder to compensate, leading to strain and potential dysfunction. Strengthening the core, can alleviate pressure on the pelvic floor and improve its function.

5 Core Exercises for Pelvic Floor Health

Dr. Jeffcoat recommends a progressive approach to core strengthening, starting with foundational exercises and gradually increasing the challenge. Here are five exercises to incorporate into your routine:

1. Diaphragmatic Breathing (Belly Breathing): This foundational exercise teaches you to engage the diaphragm, a key component of the deep core. Lie on your back with knees bent and feet flat on the floor. Place one hand on your chest and the other on your belly. Inhale deeply through your nose, allowing your belly to rise while keeping your chest relatively still. Exhale slowly through your mouth, feeling your belly fall. Focus on slow, controlled breaths.
2. Pelvic Tilts: Lie on your back with knees bent and feet flat. Gently tilt your pelvis backward, flattening your lower back against the floor. Hold for a few seconds, then release. This exercise helps improve awareness of pelvic positioning and engages the abdominal muscles.
3. Transversus Abdominis Activation (TA Draw-In): Lie on your back with knees bent. Imagine drawing your belly button towards your spine without holding your breath or tilting your pelvis. Consider feel a gentle tightening of your abdominal muscles. Hold for a few seconds, then release.
4. Bird Dog: Start on your hands and knees, ensuring your back is flat. Simultaneously extend one arm forward and the opposite leg backward, maintaining a neutral spine. Engage your core to prevent arching or twisting. Hold for a few seconds, then return to the starting position and repeat on the other side.
5. Dead Bug: Lie on your back with knees bent at 90 degrees and arms extended towards the ceiling. Slowly lower one arm and the opposite leg towards the floor, keeping your lower back pressed against the ground. Engage your core to maintain stability. Return to the starting position and repeat on the other side.

Progression and Considerations

It’s key to start slowly and focus on proper form rather than the number of repetitions. As you get stronger, you can gradually increase the duration of holds, the number of repetitions, or add resistance. Dr. Jeffcoat stresses the importance of listening to your body and stopping if you experience any pain. She has lectured internationally on female sexual health and pelvic pain, including presentations at the American Urogynecologic Association and UCLA Urogynecology and MIGS Lecture Series.

Individuals with pre-existing pelvic floor dysfunction, such as prolapse or severe incontinence, should consult with a pelvic floor physical therapist before starting any new exercise program. A qualified therapist can assess your specific needs and develop a personalized plan. Jeffcoat likewise founded the Empower Health Fund, a nonprofit providing no-cost pelvic health services to low-income populations, demonstrating her commitment to accessible care.

Strengthening your core is a proactive step towards improving your pelvic health and overall well-being. By incorporating these exercises into your routine and prioritizing proper form, you can build a strong foundation for a healthier, more comfortable life.

Disclaimer: This article provides informational content only and is not intended to be a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions you may have regarding your health or treatment.

What core exercises have you found most helpful for your overall health? Share your experiences in the comments below, and please share this article with anyone who might benefit from this information.