Health

Premier League round-up: Arsenal come back to win, Man City meet draw

2023-02-19 17:29:52.0 Source: Xinhuanet
Author: Zhang Wei

Arsenal, which experienced a small trough before, won a key victory on the 18th. They reversed and defeated Aston Villa 4:2 following falling behind twice, and continued to maintain their advantage in the championship competition.

Manchester City, which overwhelmed the “leader” in the last round, was tied 1:1 by Nottingham Forest at the last moment, and continued to rank second in the league with a 2-point disadvantage in the case of one more game.

After losing the “Battle of Tianwangshan” in the last round, Arsenal have a record of 1 draw and 2 losses in the last three rounds of the Premier League. Compared with their previous impressive report card, it has been a small trough for Arsenal recently.

In the away game once morest Villa on the 18th, Arsenal conceded the first goal in just five minutes of the game. The home team counterattacked with a long pass, and Watkins scored with a low shot. However, Mings made a header error in the 16th minute, giving Arsenal a chance. Saka volleyed from the penalty area to equalize the score. Villa then continued to maintain the offensive and scored once more in the 31st minute. Coutinho received a pass from his teammate from the left in the penalty area and succeeded in a low shot, and Villa once once more took the lead.

Low tide continues? Arsenal disagree. In the 61st minute, Zinchenko took a long shot from outside the penalty area, and the ball got close to the goal post and went into the net. The balance of luck also seems to be in favor of Arsenal. In the 93rd minute, Jorginho took a long shot from outside the penalty area. The ball hit the crossbar and bounced off the head of Villa goalkeeper Martinez and bounced into the net. Before the final whistle, Villa got a corner kick and Martinez also rushed forward to participate in the attack. Arsenal launched a quick counterattack following a clearance, and Martinelli pushed the empty goal to lock the score at 4:2.

Manchester City, which managed to catch up with Arsenal, was not so lucky. Although they relied on Bay Silva’s left-footed shot before the end of the first half to take the lead, many attacks following that failed. Nottingham Forest replaced Wood in the 79th minute, and the high center forward outflanked the goal five minutes later. In the end, the defending champion, who had 23 shots in the game, might only take one point away from Nottingham.

On the same day, Chelsea lost 0:1 at home to Southampton, which was ranked bottom, Liverpool beat Newcastle United 2:0 away, Everton beat Leeds United 1:0, Fulham beat Brighton 1:0, Brent Ford drew 1:1 with Crystal Palace, and Wolves lost 0:1 to Bournemouth.

Researchers at the University of Colorado Anschutz Medical Campus, in collaboration with their partners, have made a breakthrough by becoming the first to treat MYC amplified Medulloblastoma at a genetic level.

The researchers of University of Colorado Anschutz Medical Campus, in partnership with the German Cancer Consortium (DKTK) University Hospital Dusseldorf, have made a significant discovery in the fight once morest MYC amplified Medulloblastoma. They have found a drug combination that holds promise for providing a more favorable outcome for children diagnosed with this often deadly form of brain cancer.


“An oncogene called MYC is amplified in these tumors making them very susceptible to recurrence. In addition, there’s a greater risk of it spreading to other areas of the brain and down the spine,” said Siddhartha Mitra, Ph.D., assistant professor of Hematology-Oncology and Bone Marrow Transplant at the University of Colorado School of Medicine and University of Colorado Cancer Center member. “The five-year survival rate of this cancer is less than 45 percent. We wanted to discover better treatment options for these kids.”

Mitra’s team discovered that two drugs which have already cleared phase I safety trials in other solid tumors have a significant impact on these tumors when used together.

Using the epigenetic drug tacedinaline, the team discovered that in addition to making tumors grow, MYC was also hiding the tumors from the various immune cells in the body. They were able to unblock what are referred to as ‘don’t eat me pathways’ that prevent macrophages in the immune system from consuming a tumor.


Then they made the tumor more enticing.

“When we used tacedinaline to unblock those pathways, and then added anti-CD47, a drug which makes macrophages become super eaters, the tumor became extremely appetizing to the macrophages enticing them to eat the tumor that was unblocked,” Mitra said. “You are essentially harnessing the body’s own immune system by giving it a jumpstart, much like a medical version of PacMan.”

Mitra, who is also part of The Center for Cancer and Blood Disorders at Children’s Hospital Colorado, said that while traditional therapies like chemotherapy have previously targeted the tumor growth pathways this is the first time pathway immune evasion pathways are being targeted in these types of devastating brain tumors.

“Traditional adult cancer drugs don’t work well in kids because children are still developing and their normal cells divide at a rapid pace,” said Mitra. “This drug combination might potentially help not only minimize the negative impacts of traditional cancer treatment in kids but also give patients diagnosed with MYC amplified Medulloblastoma a better chance at survival.”


He said the next step will be a clinical trial to determine both the short and long-term effects of this treatment. In addition to the Mitra lab, the Labs of Dr. Sujatha Venkatraman and Professor Rajeev Vibhakar from CU-Anschutz were also involved.

Reference: “Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation” . by Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Nan Qin, Lena Blumel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Allison Cole, Joselyn Cruz-Cruz, Claus M Graef, Matthias Wölfl , Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Stephen T Keir, Darell D Bigner, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Arndt Borkhardt, Thomas Kurz, Marc Remke and Siddhartha Mitra, 13 January 2023, Journal of Immunotherapy.
DOI: 10.1136/jitc-2022-005871

04:13 PM

Sunday, February 19, 2023

I wrote – Omnia Qalawun:

Some people complain of a rapid heartbeat when performing an activity such as standing, sitting or lying down, but it often stabilizes when changing the position of the body, so what does the appearance of this symptom indicate?

In the next report, The Consulto reviews symptoms that indicate a rapid heartbeat when standing, according to the British NHS health insurance website.

Symptoms of postural tachycardia syndrome

You may have symptoms of postural tachycardia syndrome (PoTS) when you stand but improve when you lie down. Symptoms associated with an increased heart rate include:

Dizziness or lightheadedness.

Fainting.

Noticeable heartbeat or heart palpitations.

-Source.

-shortness of breath.

– Sweating.

You may also have other symptoms, such as:

stomach or digestion problems; Such as feeling sick, tired, diarrhoea, constipation, bloating or abdominal pain.

Headache and vision problems, such as blurred vision or tunnel vision; It is a loss of vision around the eye while preserving visual acuity.

Your hands and feet look purple.

Weakness and extreme fatigue, which is reflected in the inability to do a lot of exercise and difficulties in sleeping.

Brain fog, which manifests as problems with thinking, memory, and concentration.

Doctors point out that the above symptoms may occur with high blood pressure and are not limited to postural tachycardia syndrome.

Also read: When does heart rate indicate danger?

Causes of postural tachycardia syndrome

It can develop suddenly or gradually over time. Some people have mild symptoms, while others can have a significant impact on their daily life. You may find that your symptoms get worse in the morning, and they may change from day to day. Certain things can make your symptoms worse. like:

Feeling hot.

Eating, especially refined carbohydrates such as white bread.

Not drinking enough fluids.

Rest a lot.

Women during their menstrual periods.

Also read: Do you suffer from an irregular heartbeat?..a method that may help you overcome it

Diagnosis of positional tachycardia syndrome

You have symptoms of postural tachycardia syndrome (PoTS). Your doctor may check your blood pressure and heart rate before and following standing up. The specialist may perform further tests, such as:

-Blood tests

Urine tests.

Heart and blood pressure tests, such as echocardiogram, ECG, 24-hour blood pressure, and heart rate monitoring

It can take time for people to be diagnosed with PoTS, because the symptoms are similar to the cases.

Treatments for positional tachycardia syndrome

If you have been diagnosed with postural tachycardia syndrome (PoTS), finding the right treatment for you may take time. Doctors follow more than one treatment approach, including the following:

A change in lifestyle

A professional may suggest making changes to your lifestyle, such as eating and drinking at regular times and trying to manage stress first.

-pharmaceutical

You may also need to try several different medications or combinations of medications. You may be prescribed medications to help control your symptoms, such as beta-blockers, stimulants, and selective serotonin reuptake inhibitors (SSRIs).

Tips for preventing positional tachycardia syndrome

Positional tachycardia syndrome can be prevented by taking the following steps:

Drink plenty of fluids until the urine becomes pale.

Do light exercises such as walking, jogging, pilates, and swimming.

Raise the head of the bed so you don’t lie completely flat.

Wear support stockings to improve blood flow.

Not standing for a long time.

Not getting up quickly following lying down.

Not sitting for a while before standing.

Avoid excessive intake of caffeine or alcohol.

Also read: By age.. How can the heart rate be checked?