Health

The Netherlands will not reimburse the cost of lecanemab (Leqembi®), a recently approved drug for early-stage Alzheimer’s disease, after the Zorginstituut Nederland – the country’s healthcare institute – concluded it offers insufficient benefit to patients given its potential for serious side effects. The decision, announced on Wednesday, February 18, 2026, marks a setback for those hoping for a breakthrough in treating the debilitating neurodegenerative disease.

While lecanemab represents the first medication aimed at slowing the progression of Alzheimer’s, the Zorginstituut’s assessment found the clinical improvements experienced by patients were too small to justify the drug’s cost and risks. The institute advises the Minister of Health, Welfare and Sport against including lecanemab in the standard benefits package of health insurance. This means patients will likely have to pay for the treatment out-of-pocket, if it becomes available at all.

Limited Efficacy and Significant Risks

Alzheimer’s disease, a progressive condition affecting memory, thinking, and behavior, impacts a significant portion of the population. Symptoms typically include forgetfulness, confusion, and difficulty with language. According to the Zorginstituut Nederland, lecanemab is designed for individuals in the early stages of the disease, specifically those with mild cognitive impairment and mild dementia. However, research indicates that even in this group, the drug’s effect on slowing cognitive decline is modest.

More concerningly, lecanemab carries a risk of serious side effects, including brain bleeding and swelling. These adverse events can sometimes be severe, leading to paralysis, speech difficulties, or even death, though such outcomes are rare. Patients may not always experience noticeable symptoms from these side effects, but the potential for harm weighed heavily in the Zorginstituut’s decision. The drug is administered via bi-weekly injections in a hospital setting, adding to the logistical and financial burden.

How Lecanemab Works and Why It Fell Short

Lecanemab functions by targeting and removing amyloid plaques, protein deposits that accumulate in the brains of people with Alzheimer’s disease. While the exact cause of Alzheimer’s remains unknown, these plaques are believed to play a role in the disease’s progression. The drug’s mechanism of action – clearing these protein build-ups – was not enough to demonstrate a substantial clinical benefit for patients, according to the Zorginstituut’s evaluation. The institute concluded that the limited impact on disease progression did not outweigh the potential for serious adverse reactions.

The cost of lecanemab is also a significant factor. Estimates place the annual cost of treatment at around €25,000 per patient, excluding additional expenses related to hospital visits and brain scans, as reported by Nationale Zorggids. Experts suggest that these funds could be better allocated to proven effective care and support services for Alzheimer’s patients and their families.

A Disappointment for Patients and Families

The decision not to reimburse lecanemab is a significant disappointment for patients and their loved ones who had hoped for a more effective treatment option. As stated in AD.nl, it is a “big disappointment” that the drug does not represent a breakthrough. Despite the setback, research into new Alzheimer’s treatments continues, and other potential therapies are currently under development. The Zorginstituut is also expected to review another Alzheimer’s drug, donanemab, at a later date, though a timeline for that assessment has not yet been announced.

The debate surrounding lecanemab highlights the challenges of developing and evaluating treatments for complex diseases like Alzheimer’s. Balancing the potential benefits of a new drug against its risks and costs requires careful consideration, and the Zorginstituut’s decision reflects a commitment to ensuring that healthcare resources are used effectively.

Looking ahead, the focus will remain on improving the quality of life for individuals living with Alzheimer’s disease and supporting ongoing research efforts to find more effective treatments. The need for comprehensive care, including early diagnosis, supportive therapies, and respite care for caregivers, remains paramount.

What are your thoughts on this decision? Share your comments below, and please share this article with your network.

Disclaimer: This article provides informational content only and is not intended to be a substitute for professional medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment of any medical condition.

As we age, changes in sleep patterns are often dismissed as a natural part of getting older. Whereas it’s true that sleep needs can evolve with age, persistent sleep disturbances – including difficulty falling asleep, frequent awakenings, and early morning rising – shouldn’t be ignored. These could be indicators of underlying sleep disorders, such as insomnia, restless legs syndrome, or sleep apnea, which can significantly impact overall health and well-being.

The perception of simply needing “less sleep” as we age often overshadows the crucial role sleep quality plays in cognitive function, physical health, and emotional stability. Experts emphasize that while the amount of sleep may decrease slightly with age – the average senior getting around 6-7 hours compared to the typical adult’s 7-8 hours according to recent reports – the efficiency of that sleep is often compromised. This means seniors may spend more time in bed but less time in restorative, deep sleep.

Understanding Age-Related Changes in Sleep

Several factors contribute to these shifts in sleep architecture. As individuals age, the production of melatonin, a hormone regulating the sleep-wake cycle, tends to decline. This can disrupt the body’s natural circadian rhythm, leading to earlier sleepiness in the evening and earlier awakenings in the morning. The depth of sluggish-wave sleep (stage 3 non-REM sleep), which is vital for physical restoration and memory consolidation, diminishes with age. This results in more fragmented sleep and a feeling of being unrested despite spending adequate time in bed.

Changes in lifestyle also play a role. Reduced physical activity, increased prevalence of chronic medical conditions, and the use of certain medications can all interfere with sleep. Seniors may also experience less exposure to sunlight, which is a key regulator of the circadian rhythm. According to a report from Daum News, decreased sunlight exposure weakens the body’s ability to reset its internal clock, potentially exacerbating sleep problems.

Common Sleep Disorders in Older Adults

Beyond the natural changes in sleep patterns, several specific sleep disorders are more common in older adults:

• Insomnia: Characterized by difficulty falling asleep, staying asleep, or experiencing non-restorative sleep.
• Restless Legs Syndrome (RLS): A neurological disorder causing an irresistible urge to move the legs, often accompanied by uncomfortable sensations.
• Sleep Apnea: A condition where breathing repeatedly stops and starts during sleep, leading to fragmented sleep and daytime sleepiness.

It’s important to note that these conditions can often co-occur, making diagnosis and treatment more complex. Untreated sleep disorders can have serious consequences, increasing the risk of falls, cardiovascular disease, cognitive decline, and mood disorders.

Recognizing the Signs and Seeking Help

Differentiating between normal age-related sleep changes and a sleep disorder can be challenging. Although, certain symptoms warrant medical attention. These include:

• Excessive daytime sleepiness
• Difficulty concentrating
• Mood changes, such as irritability or depression
• Memory problems
• Frequent awakenings during the night
• Loud snoring or gasping for air during sleep (potentially indicating sleep apnea)

If you or a loved one is experiencing these symptoms, it’s crucial to consult a healthcare professional. A sleep study may be recommended to diagnose the underlying cause of the sleep disturbance and determine the most appropriate treatment plan. Recent reporting from Nate News highlights the importance of not dismissing sleep changes as simply a part of aging, especially when accompanied by daytime impairment.

Experts also caution against self-treating with over-the-counter sleep aids, as these can have side effects and may mask underlying medical conditions. A comprehensive evaluation by a physician is essential to ensure accurate diagnosis and personalized care.

As the population ages, understanding and addressing sleep disorders in seniors becomes increasingly important. Prioritizing sleep health is not just about feeling rested. it’s about preserving cognitive function, maintaining physical health, and enhancing overall quality of life.

Looking ahead, continued research into the mechanisms of age-related sleep changes and the development of targeted interventions will be crucial in improving sleep health for older adults. Increased awareness among healthcare providers and the public will also play a vital role in ensuring that sleep disorders are recognized and treated effectively.

Have you or a loved one experienced changes in sleep patterns with age? Share your thoughts and experiences in the comments below.

Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

The daily life of a child with food allergies, and their family, extends far beyond avoiding specific ingredients. It’s a constant state of vigilance, a complex interplay of anxiety, social limitations, and emotional strain that significantly impacts overall quality of life. While medical advancements continue to improve allergy management, a growing understanding emphasizes the profound psychological and social burdens these conditions place on individuals and families.

Food allergies affect an estimated 32 million Americans, including approximately 5.6 million children under age 18, according to the Food Allergy Research & Education (FARE) organization. https://www.foodallergy.org/resources/facts-and-statistics But the numbers only tell part of the story. The pervasive fear of accidental exposure, the need for constant label reading, and the challenges navigating social situations like school lunches and birthday parties create a unique set of stressors that can profoundly affect mental well-being.

The Emotional Landscape of Food Allergies

Pediatric allergist Tina Sindher, clinical associate professor of pediatrics and allergy/immunology at Stanford Health Care, has dedicated her career to understanding and addressing the multifaceted challenges of childhood food allergies. Dr. Sindher’s operate focuses on clinical trials involving children with food allergies and expanding research into less common forms of food allergy, such as food protein-induced enterocolitis (FPIES) and eosinophilic esophagitis (EoE). https://med.stanford.edu/allergyandasthma/news/news-from-our-center/sayantani-tina-sindher.html She notes that the anxiety surrounding food allergies isn’t limited to the child; it permeates the entire family dynamic.

“Living with food allergy has a bigger quality-of-life toll than we realize,” Dr. Sindher explains in a recent Stanford report. The constant need for awareness and preparedness can lead to significant stress for parents and caregivers, impacting their own mental health and creating a ripple effect within the family. This stress can manifest as increased anxiety, difficulty sleeping, and even feelings of isolation.

Beyond Physical Reactions: Social and Practical Challenges

The impact of food allergies extends beyond the risk of physical reactions. Children with food allergies often face social exclusion, feeling different from their peers and missing out on shared experiences. Simple activities like attending birthday parties or school events can become sources of anxiety and require careful planning and coordination with school staff and other parents.

Dr. Sindher’s research has likewise included work with epicutaneous immunotherapy (EPIT), a treatment that delivers allergens via the skin, for the treatment of children with IgE-mediated milk and peanut allergy. https://med.stanford.edu/allergyandasthma/news/news-from-our-center/sayantani-tina-sindher.html While promising, these treatments are not a cure and require ongoing management. Access to specialized care and emerging therapies can be limited, creating disparities in treatment options.

The Need for a Holistic Approach

Recognizing the significant quality-of-life impact, healthcare professionals are increasingly advocating for a more holistic approach to food allergy management. This includes not only addressing the physical symptoms but also providing emotional support and resources for both the child and their family. Mental health professionals specializing in allergy and immunology are becoming increasingly essential members of the care team.

Dr. Sindher completed her fellowship training in Allergy and Immunology at Children’s Hospital of Philadelphia, where she participated in clinical trials. https://www.stanfordchildrens.org/content/sch/us/en/doctor/s/sayantani-bhattacharya-sindher She also has been involved in research on less common forms of food allergy, such as food protein induced enterocolitis (FPIES) and eosinophilic esophagitis (EoE).

Looking ahead, continued research into new treatments and preventative strategies is crucial. However, equally important is raising awareness about the emotional and social challenges associated with food allergies and ensuring that families have access to the support they need to navigate this complex condition. The focus must shift towards not just preventing reactions, but also fostering a sense of normalcy and well-being for those living with food allergies.

What are your experiences with managing food allergies? Share your thoughts in the comments below.

Disclaimer: This article provides informational content and should not be considered medical advice. Please consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.