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Eric Dane, the actor celebrated for his roles as Dr. Mark Sloan in Grey’s Anatomy and Cal Jacobs in Euphoria, has died at the age of 53. His passing follows a battle with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease, and marks a significant loss for the entertainment industry.
Dane’s family confirmed his death in a statement to People, noting he passed away on Thursday afternoon surrounded by loved ones, including his wife, Rebecca Gayheart, and their two daughters, Billie, and Georgia. The family highlighted his dedication to raising awareness and funding research for ALS during his illness, stating he “became a passionate advocate for awareness and research, determined to make a difference for others facing the same fight.”
Throughout a career spanning decades, Eric Dane appeared in numerous television shows and films, including Charmed, The Last Ship, Marley & Me, Valentine’s Day, and Burlesque. However, he achieved widespread recognition for his portrayal of Dr. Mark Sloan, affectionately known as “McSteamy,” on Grey’s Anatomy, a role he held for six years beginning in 2006. His character remained a fan favorite long after his departure from the series.
More recently, Dane garnered critical acclaim for his performance as Cal Jacobs, Nate’s father, in HBO’s Euphoria, beginning in 2019. His nuanced portrayal in the show’s second season sparked widespread praise and calls for an Emmy Award. He had already filmed scenes for the upcoming third season of Euphoria and will appear in the final cut, according to reports.
ALS Diagnosis and Advocacy
Eric Dane publicly revealed his diagnosis of ALS in April 2025, as reported by People. ALS, also known as Lou Gehrig’s Disease, is a progressive disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually, death. Following his diagnosis, Dane actively sought to raise awareness about the condition and support research efforts. He even took on a role in an episode of Brilliant Minds portraying a firefighter grappling with an ALS diagnosis, demonstrating his commitment to shedding light on the challenges faced by those living with the disease.
ALS is a relatively rare disease, affecting approximately 5 to 20 people per 100,000, according to the National Institute of Neurological Disorders and Stroke (NINDS).
Tributes from Colleagues and Fans
Tributes have poured in from Dane’s colleagues and fans across social media. Grey’s Anatomy co-stars Kim Raver, Kevin McKidd, and James Pickens Jr. Have expressed their grief and shared fond memories. Sam Levinson, the creator of Euphoria, released a statement saying, “I’m heartbroken by the loss of our dear friend Eric. Working with him was an honor. Being his friend was a gift. Eric’s family is in our prayers. May his memory be for a blessing.”
Eric Dane is survived by his wife, Rebecca Gayheart, and their daughters, Billie and Georgia. The family has requested privacy during this difficult time.
The entertainment world mourns the loss of a talented actor and a courageous advocate. The final season of Euphoria will now serve as a poignant tribute to his memory, offering audiences a final glimpse of his compelling work. As production on the series continues, the impact of his dedication and artistry will undoubtedly be felt by cast and crew alike.
If you are affected by ALS or understand someone who is, resources are available. You can discover more information and support from organizations like the ALS Association.
Please share your thoughts and memories of Eric Dane in the comments below.