Home » Development of an AI model to detect carcinogenic substances→Prediction of melphalan, sulfur mustard, etc. India|Indian Science and Technology News|Science Portal India Conveying the present state of science and technology in India

Development of an AI model to detect carcinogenic substances→Prediction of melphalan, sulfur mustard, etc. India|Indian Science and Technology News|Science Portal India Conveying the present state of science and technology in India

by archyde

A team of Indian scientists has developed an artificial intelligence (AI) model to detect carcinogenic metabolites in humans.scientific journal nature india reported on August 16.Research results published in academic journals Nature Chemical Biology Published in

Foods, drugs, and other chemicals taken into the human body produce various metabolites when broken down in the body. Some metabolites also transform healthy human cells into carcinogenic cells. However, animal experiments to screen for such carcinogenic metabolites are expensive and time-consuming.

Now, researchers at India’s La Prassa Institute of Information Technology Delhi (IIIT-D) have developed a faster and better screening system, dubbed Metabokiller. This system consists of six model families that classify human carcinogenic metabolites based on their ability to induce oxidative stress, proliferation, genomic instability, and anti-apoptosis.

In addition to IIIT-D, the research group includes researchers from the Institute of Genome and Integrated Biology, Indian Institute of Scientific and Industrial Research (CSIR) and the Indian Institute of Technology Ropar (IIT Ropar).・217,921 metabolites registered in the database (HMDB) were screened.

As a result, approximately 37.5% of the metabolites were predicted to be carcinogenic, 38 of which were previously identified as carcinogens. Metabolites predicted to be carcinogenic include melphalan, sulfur mustard, dichloroethane, chloral, and trichloroethane.

The research team also exposed budding yeast cells and human lung epithelial cells to the putative carcinogenic metabolites 4-nitrocatechol and 3,4-dihydroxyphenylacetic acid to confirm the effects of Metabokiller. As a result, malignant transformation was observed in cells with any of the chemical substances, suggesting the effectiveness of the model.

Science Portal Asia Pacific Editorial Department

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