2023-08-15 23:48:45
https://www.crtonline.org/……/hyperthermia-does-not……
## 15 bullet points
– The TTM2 trial investigated the effect of hypothermia versus maintenance of normothermia on social engagement and cognitive function in patients 6 months following cardiac arrest.
– The trial found no significant differences between the two groups in areas such as social engagement and cognitive function.
– Lack of face-to-face interviews and interactions influenced results, researchers note; sample size was determined by survival, so not all patients might be followed up.
– The study is limited to survivors of cardiac arrest.
– Past literature indicates that cognitive function and social engagement are negatively affected in survivors of cardiac arrest.
– The trial included 1,861 patients with an average age of 60 years, 84% of whom were men.
– All patients have limited social participation.
– Cognitive impairment was present in 59% of patients.
– As assessed, hypothermia was not helpful for cognitive function and social participation following cardiac arrest.
– The researchers note that the results of this study suggest that there is no clinically significant benefit of hypothermia over maintenance of normothermia.
– Researchers stress that hypothermia should no longer be used as a strategy for neuroprotection following cardiac arrest in the future.
– Follow-up for this trial was completed in October 2020.
– Patients were randomized into hypothermia and normothermia groups.
– Patients were cooled only when their body temperature exceeded 37.8 degrees in the hypothermia group.
– The results of this trial cannot be generalized to all patients with cardiac arrest.
## in conclusion
This study found that hypothermia, compared with maintenance of normothermia, did not improve cognitive function and social engagement following cardiac arrest. Therefore, hypothermia should no longer be considered as a strategy for neuroprotection following cardiac arrest in the future.
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