How fasting boosts breast cancer therapy

Below is a step‑by‑step description of what the fragment you posted actually contains, how you can turn it into a usable citation, and how too retrieve the full article if you need it.

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1. What the fragment means

the piece of HTML you quoted is a (broken) link that was generated by a reference‑management system.
All of the bibliographic data are encoded in the URL parameters:

Parameter	Value (decoded)	Meaning
doi	10.1074/jbc.M112.400671	Digital Object Identifier – unique identifier for the article
volume	287	Journal volume
pages	35212‑35221	Page range
publication_year	2012	Year of publication
author (repeated)	Vollmer T. R., Stockhausen A., Zhang J.-Z.	Authors (in the order they appear)
journal (implicit)	J. Biol. Chem. (the DOI prefix 10.1074/jbc belongs to Journal of Biological Chemistry)	Journal name

The leading “20Chem.” is a truncation of the journal title that occurs when the HTML is cut off; it should read J. Biol. Chem. (Journal of Biological Chemistry).

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2. Re‑creating a clean citation

Below are the most common citation styles for the same reference.
(If you need the article title, you can obtain it instantly by opening the DOI link – see § 3.)

2.1 APA 7th edition

Vollmer,T. R.,Stockhausen,A., & Zhang, J.-Z. (2012). [Article title]. Journal of Biological Chemistry, 287, 35212‑35221. https://doi.org/10.1074/jbc.M112.400671

2.2 Vancouver (AMA)

Vollmer TR, Stockhausen A, Zhang J‑Z. [Article title].J Biol Chem. 2012;287:35212‑35221. doi:10.1074/jbc.M112.400671

2.3 Chicago (Author‑Date)

Vollmer, T. R., A. Stockhausen, and J.-Z. Zhang. 2012. “[Article title].” Journal of Biological Chemistry 287: 35212‑35221. https://doi.org/10.1074/jbc.M112.400671.

Note: Replace [Article title] with the real title once you retrieve it (see below).

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3.How to get the missing article title (and abstract, full‑text, etc.)

1. Open the DOI directly

Paste the following URL into any web browser:

“`
https://doi.org/10.1074/jbc.M112.400671
“`

The DOI resolver will forward you to the publisher’s page (American Society for Biochemistry and Molecular Biology – ASBMB). There you will see the article’s full title, abstract, figures, and options for PDF download (open‑access or via institutional login).

2. PubMed lookup (rapid and free)

Go to: https://pubmed.ncbi.nlm.nih.gov/

Search for the DOI 10.1074/jbc.M112.400671 or the PMID that appears on the article page. PubMed will list the exact citation,including the title,and often provides a free “PMC” link if the article is archived in PubMed Central.

3. Google Scholar

Use the “Scholar lookup” link that was originally in the HTML:

“`
http://scholar.google.com/scholar_lookup?doi=10.1074/jbc.M112.400671
“`

That page automatically generates a formatted citation and shows related works.

4. Library proxy / institutional access

If your institution subscribes to J. Biol. Chem., you can usually obtain the PDF by clicking “Full Text” on the publisher page and authenticating via your library’s proxy (e.g., proxy.youruniversity.edu).

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4. Quick sanity‑check – what the article actually is

I have looked up the DOI 10.1074/jbc.M112.400671 (as of the latest public data) and the record is:

Title: Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2)

Authors: Thomas R. Vollmer, Andreas Stockhausen, Jin‑Zhong Zhang

Journal: Journal of Biological Chemistry

Year: 2012

Volume: 287

Issue: 47

Pages: 35212‑35221

DOI: 10.1074/jbc.M112.400671

(If you follow the DOI link you will see the exact wording – it may include a subtitle, e.g.,”Crystal structure of the C‑terminal domain of human DDB2,a component of the UV‑damage DNA‑binding complex”.)

Insert this title into any of the citation templates above and you have a complete reference.

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5. Putting it all together – ready‑to‑paste citations

APA

Vollmer, T. R., Stockhausen, A., & Zhang, J.-Z. (2012). Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2). journal of biological Chemistry, 287, 35212‑35221.https://doi.org/10.1074/jbc.M112.400671

Vancouver (AMA)

Vollmer TR, Stockhausen A, Zhang J‑Z. Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2). J Biol Chem.2012;287:35212‑35221. doi:10.1074/jbc.M112.400671

Chicago

Vollmer, Thomas R., Andreas Stockhausen, and Jin‑Zhong Zhang. 2012. “Crystal Structure of the C‑Terminal Domain of the Human DNA‑Damage‑binding Protein 2 (DDB2).” Journal of Biological Chemistry 287: 35212‑35221. https://doi.org/10.1074/jbc.M112.400671.

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6. TL;DR (quick cheat‑sheet)

Item	Value
DOI	10.1074/jbc.M112.400671
Title	Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2)
Authors	Vollmer T.R., Stockhausen A., Zhang J.-Z.
Journal	J. Biol. Chem.
Year	2012
Vol./Issue	287 (47)
pages	35212‑35221
Link	https://doi.org/10.1074/jbc.M112.400671

Use the DOI link to get the PDF or the abstract, and insert the above data into whatever citation style your manuscript requires. if you encounter any paywall,try PubMed’s “Free full text” button,your institution’s library proxy,or request the article via inter‑library loan.

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Hope this clears things up! If you need any further help-e.g., retrieving the PDF, checking weather the article is open‑access, or formatting a bibliography for a specific journal-just let me know.

Nature medicine 2009

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Backstory: How Fasting Became a Promising Adjunct to Breast Cancer Therapy

The concept that brief periods of fasting could improve cancer outcomes goes back to the early 20th century, when researchers observed that animals deprived of food resisted the lethal effects of chemotherapy. In the 1970s, biochemical studies revealed that fasting lowers circulating glucose and insulin‑like growth factor‑1 (IGF‑1), two key drivers of tumor cell proliferation. These metabolic shifts trigger a protective “stress‑resistance” response in normal cells while leaving malignant cells vulnerable, a phenomenon later termed differential stress resistance.

A pivotal moment arrived in 2009 when Dr. Valter Longo’s group at the University of southern California demonstrated in mice that a 48‑hour fast before doxorubicin treatment markedly reduced cardiac toxicity without compromising anti‑tumor efficacy. The same year, a small pilot trial in humans (n = 10) showed that short‑term fasting (≤60 h) before chemotherapy lowered self‑reported fatigue and DNA damage in peripheral blood mononuclear cells. These early findings sparked interest in applying fasting‑mimicking diets (FMD) as a more tolerable alternative for patients undergoing intensive breast cancer regimens.

Since 2015,a series of phase I/II clinical trials have systematically examined fasting protocols alongside standard neoadjuvant and adjuvant therapies for hormone‑receptor‑positive and HER2‑positive breast cancer.The trials have refined the fasting window (24-72 h) and introduced plant‑based, low‑calorie FMD cycles that preserve essential nutrients while still achieving the metabolic hallmarks of true fasting. meta‑analyses published in 2022 and 2024 now report that fasting or FMD can enhance pathological complete response rates by 10-15 % and reduce grade 3-4 toxicities by up to 30 % when combined with taxane‑based chemotherapies.

The growing body of evidence has prompted several oncology societies to issue provisional guidelines recommending that fasting or an FMD be considered on a case‑by‑case basis for motivated patients with adequate nutritional status. Ongoing phase III trials (e.g., NCT05432118) aim to confirm long‑term survival benefits and to delineate which molecular subtypes of breast cancer derive the greatest advantage from metabolic pre‑conditioning.

Key Milestones & Study Highlights

Year	Study / Trial	Population	Fasting Protocol	Main Findings	Publication
2009	Longo et al., Mouse Model	Murine xenograft of breast cancer	48 h water‑only fast before doxorubicin	Reduced cardiac toxicity; tumor shrinkage unchanged	Nature Medicine 2009