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Icotrokinra Shows Promise in Psoriasis Treatment, Outperforming Existing Drug in Trials
Table of Contents
- 1. Icotrokinra Shows Promise in Psoriasis Treatment, Outperforming Existing Drug in Trials
- 2. Superior results in ICONIC-ADVANCE Trials
- 3. Long-Term Efficacy Confirmed in ICONIC-LEAD Study
- 4. Understanding Icotrokinra and Its Potential
- 5. What is the clinical significance of icotorokinra achieving a statistically significant higher PASI 75 response rate at week 16 compared to deucravacitinib?
- 6. Icotorokinra Surpasses Deucravacitinib in Psoriasis Head-to-head Trial: A Pharmacy Times Report
- 7. Key Findings of the Clinical Trial
- 8. Understanding the Medications: Icotorokinra vs.Deucravacitinib
- 9. Icotorokinra: A selective IL-23 inhibitor
- 10. Deucravacitinib: A TYK2 Inhibitor
- 11. Implications for Psoriasis treatment
- 12. Real-World Considerations & Patient Monitoring
- 13. Psoriasis & the IL-23 Pathway: A Deeper Dive
New data presented at the 2025 European Academy of Dermatology and Venereology suggest a potential breakthrough in the treatment of moderate-to-severe plaque psoriasis.Icotrokinra, an investigational targeted oral peptide, has demonstrated superior skin clearance compared to deucravacitinib, a currently available medication, in recent phase 3 clinical trials.
Superior results in ICONIC-ADVANCE Trials
The ICONIC-ADVANCE 1 and 2 studies revealed that individuals receiving icotrokinra experienced substantially better skin clearance at both 16 and 24 weeks compared to those treated with deucravacitinib. Importantly,patients taking icotrokinra reported a numerically lower incidence of adverse events.
Linda Stein Gold, MD, a lead investigator in the ICONIC-ADVANCE study, emphasized the implications of the findings. “These head-to-head data clearly demonstrate superior complete skin clearance rates for icotrokinra compared to deucravacitinib,” she stated. “With significantly higher response rates seen as early as week 16 and increasing at week 24, this novel targeted oral peptide treatment has the potential to be an appealing new option for patients.”
Long-Term Efficacy Confirmed in ICONIC-LEAD Study
Reinforcing these promising results, the 52-week ICONIC-LEAD study provided evidence of sustained skin clearance and a favorable safety profile. Adults who initially responded to icotrokinra and were then re-randomized to continue the treatment maintained a significantly higher rate of skin clearance compared to those switched to a placebo (84% versus 21%).
The study also showed positive outcomes for adolescent patients. Approximately 86% of adolescents treated with icotrokinra for the full 52 weeks, and 77% of those who transitioned from placebo to icotrokinra at week 16, achieved substantial improvements in their condition.
Understanding Icotrokinra and Its Potential
Icotrokinra is a first-in-class investigational drug designed to target specific pathways involved in psoriasis. Prior research, including the ICONIC-TOTAL trial, has demonstrated its effectiveness in treating difficult-to-treat forms of the condition, such as scalp and genital psoriasis.
Did You Know? Psoriasis affects more than 7.5 million adults in the United States, according to the National Psoriasis Foundation.
| Study | Key Findings | Duration |
|---|---|---|
| ICONIC-ADVANCE 1 & 2 | Icotrokinra superior to deucravacitinib in skin clearance; numerically fewer AEs. | 16-24 weeks |
| ICONIC-LEAD | Sustained skin clearance for up to 52 weeks
What is the clinical significance of icotorokinra achieving a statistically significant higher PASI 75 response rate at week 16 compared to deucravacitinib?
Icotorokinra Surpasses Deucravacitinib in Psoriasis Head-to-head Trial: A Pharmacy Times ReportKey Findings of the Clinical TrialRecent data published by Pharmacy Times highlights a significant advancement in psoriasis treatment. A head-to-head clinical trial demonstrates that icotorokinra, an interleukin-23 (IL-23) inhibitor, achieved superior results compared to deucravacitinib, a tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate-to-severe plaque psoriasis. This represents a potentially crucial shift in treatment paradigms for individuals struggling with this chronic inflammatory skin condition. * PASI 75 Response: Icotorokinra demonstrated a statistically significant higher PASI 75 response rate at week 16 compared to deucravacitinib. PASI 75, or Psoriasis Area and Severity Index 75, signifies a 75% advancement in psoriasis symptoms. * PASI 90 & PASI 100: The trial also showed improved rates of PASI 90 (90% improvement) and PASI 100 (complete clearance) with icotorokinra. * Safety Profile: While both medications demonstrated acceptable safety profiles, icotorokinra showed a comparable safety profile to deucravacitinib, with no unexpected adverse events. This is a critical factor for long-term adherence to treatment. * Targeted Inhibition: Icotorokinra specifically targets the IL-23 pathway, a key driver of inflammation in psoriasis. This targeted approach may contribute to its enhanced efficacy. Understanding the Medications: Icotorokinra vs.DeucravacitinibBoth icotorokinra and deucravacitinib represent newer systemic therapies for psoriasis, offering alternatives to customary treatments like biologics and systemic corticosteroids. However, their mechanisms of action differ considerably. Icotorokinra: A selective IL-23 inhibitorIcotorokinra is a human monoclonal antibody that selectively neutralizes IL-23. IL-23 plays a pivotal role in the pathogenesis of psoriasis by promoting the activation and proliferation of Th17 cells, which contribute to inflammation and skin lesions. By blocking IL-23, icotorokinra aims to reduce this inflammatory cascade. This targeted approach minimizes off-target effects, potentially leading to a favorable safety profile. Deucravacitinib: A TYK2 InhibitorDeucravacitinib is a small molecule inhibitor of TYK2, a Janus kinase (JAK) family member involved in signaling pathways for multiple cytokines, including those implicated in psoriasis. while effective,inhibiting TYK2 can have broader effects on the immune system,potentially increasing the risk of certain adverse events. Implications for Psoriasis treatmentThe results of this head-to-head trial have significant implications for the treatment of moderate-to-severe plaque psoriasis.
Real-World Considerations & Patient MonitoringWhile clinical trials provide valuable data, real-world submission requires careful patient selection and ongoing monitoring. * Comorbidities: Patients with pre-existing conditions, such as infections or autoimmune diseases, should be carefully evaluated before initiating treatment with either medication. * Infection Risk: Both IL-23 inhibitors and TYK2 inhibitors can potentially increase the risk of infections. patients should be monitored for signs and symptoms of infection during treatment. * Lipid levels: Monitoring lipid levels is recommended, as both medications have been associated with changes in cholesterol. * Adherence: Consistent adherence to treatment is crucial for maximizing efficacy. Patient education and support are essential. Psoriasis & the IL-23 Pathway: A Deeper DivePsoriasis is a chronic, immune-mediated inflammatory disease affecting millions worldwide. The IL-23/Th17 axis is now recognized as a central driver of psoriasis pathogenesis. * IL-23 Production: Keratinocytes and dendritic cells in psoriatic lesions produce IL-23. * Th17 Cell Activation: IL-23 activates Th17  Adblock Detected
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