Home » Health » Reevaluating Struma Ovarii: Insights into Non-invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) from a Pathologist’s Perspective

Reevaluating Struma Ovarii: Insights into Non-invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) from a Pathologist’s Perspective




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Accessing Student Portals: Mobile number Requirement for Schools

Parents and guardians are now required to have a mobile phone number registered with their child’s school to gain access to the school’s online student portal. This essential step facilitates seamless communication and access to critically important academic resources.

The Importance of Digital Access

The move towards digital school portals is a growing trend, spurred by the increasing need for efficient communication between schools, students, and families. These portals serve as central hubs for accessing grades, attendance records, school announcements, and direct communication with teachers. With the rise of remote learning and hybrid models, access to these resources became even more critical during and after the COVID-19 pandemic. According to a 2023 study by the National Center for Education Statistics, 96% of public schools now utilize some form of digital learning platform.

How the Mobile Number Verification Works

Schools are implementing mobile number verification as a security measure to ensure only authorized individuals – parents or legal guardians – have access to sensitive student information. This typically involves receiving a verification code via SMS to confirm identity prior to initial login or password resets.The procedure takes place during a student’s enrollment process.

Ensuring a Smooth Transition

To avoid any disruptions in access, parents are urged to ensure the school has their current mobile phone number on file. Schools are proactively reaching out to families to verify this information, and providing assistance to those who may need to update their contact details.
Did You Know? Many school portals now integrate with mobile apps, offering convenient access to information on the go.

Key Requirements Summarized

Requirement details
Mobile Number Registration A valid mobile phone number must be registered with the school.
Verification Process A verification code will be sent via SMS to confirm identity.
Access to Portal access to grades, attendance, and communications.

Pro Tip: Keep your school’s contact information saved in your phone for quick access and updates.

The Future of School Communication

The trend towards digital communication in education is expected to continue. Schools are increasingly exploring features like two-way messaging, online payment portals, and integrated calendars to streamline communication and enhance parental involvement. As technology evolves, so too will the methods used to connect schools and families, fostering a more collaborative and supportive learning surroundings.

Frequently Asked Questions

  • What happens if I change my mobile number? You shoudl instantly notify the school to update your contact information.
  • Is my personal information secure? Schools employ security measures to protect your data, but it’s always wise to practice safe online habits.
  • What if I don’t have a mobile phone? Contact the school to discuss alternative verification methods.
  • Can I access the portal without a smartphone? Moast portals are accessible from any device with an internet connection, including computers and tablets.
  • Why is a mobile number needed for school portal access? A mobile number serves as a secondary verification factor to enhance security and ensure authorized access to student information.

Do you think digital portals have improved communication between schools and families? What other features would you like to see added to these platforms?


What are the key morphological criteria pathologists use to identify NIFTP within a struma ovarii specimen?

Reevaluating Struma Ovarii: Insights into Non-invasive Follicular Thyroid Neoplasm with papillary-Like nuclear Features (NIFTP) from a Pathologist’s Viewpoint

Understanding Struma Ovarii & Its Ancient Context

Struma ovarii represents a fascinating and often challenging diagnostic entity for pathologists. Historically defined as a monodermal teratoma containing thyroid tissue, comprising more than 50% of the tumor mass, its classification has undergone significant evolution. The finding and subsequent characterization of Non-invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) have profoundly impacted how we approach these ovarian tumors. This article delves into the current understanding of struma ovarii, especially in light of NIFTP criteria, offering a pathologist’s perspective on diagnosis, management, and future directions. Key search terms include: struma ovarii diagnosis, NIFTP ovarian, ovarian thyroid tissue, teratoma with thyroid, follicular thyroid neoplasm ovary.

The NIFTP Paradigm Shift: Impact on Struma Ovarii Classification

The 2016 introduction of NIFTP as a distinct entity within thyroid pathology has directly influenced the evaluation of struma ovarii. Previously, manny struma ovarii were categorized as follicular adenomas or papillary thyroid carcinomas, leading to potential overtreatment. NIFTP, characterized by specific morphological features – papillary-like nuclear features without invasive characteristics – has a remarkably low risk of metastasis.

Here’s how NIFTP criteria apply to struma ovarii:

* Encapsulation: The tumor must be well-encapsulated.

* Papillary-Like Nuclear Features: Presence of nuclear grooves,inclusions,and overlapping nuclei.

* Absence of Invasion: Crucially, there should be no evidence of capsular or vascular invasion.

* Absence of High-Risk Features: Features like tall cell variant, columnar cell variant, hobnail features, or ciliated squamous morphology are exclusionary.

Applying these criteria to struma ovarii allows for a more accurate risk stratification and avoids unnecessary aggressive surgical interventions. NIFTP criteria struma ovarii, ovarian tumor pathology, thyroid cancer in ovary.

Diagnostic Challenges & Immunohistochemical considerations

Diagnosing NIFTP within a struma ovarii can be complex.Distinguishing NIFTP from other follicular neoplasms,particularly those with atypical features,requires careful evaluation. Immunohistochemistry (IHC) plays a vital role in confirming thyroid differentiation.

Commonly used IHC markers include:

* TTF-1 (Thyroid Transcription Factor-1): generally positive in NIFTP and struma ovarii.

* PAX8: Another useful marker for thyroid differentiation,often positive.

* HBME-1: Can be helpful, but lacks specificity.

* BRAF V600E: While frequently enough negative in NIFTP, it can be present in a subset of cases and is more commonly found in conventional papillary thyroid carcinoma. IHC struma ovarii, TTF-1 staining ovary, PAX8 immunohistochemistry.

It’s critically importent to note that IHC results should always be interpreted in conjunction with morphological findings. False positives and negatives can occur, emphasizing the need for a thorough pathological assessment.

Molecular Profiling: Refining Risk Stratification

While morphological assessment and IHC are crucial, molecular testing is increasingly being utilized to refine risk stratification in challenging cases of struma ovarii.

* BRAF Mutation Analysis: Detecting the BRAF V600E mutation can suggest a more aggressive behavior, possibly shifting the diagnosis away from NIFTP.

* RAS Mutations: RAS mutations are more frequently observed in follicular adenomas and can definitely help differentiate them from NIFTP.

* Next-Generation Sequencing (NGS): NGS panels can identify a broader spectrum of genetic alterations, providing a more comprehensive molecular profile.Molecular pathology struma ovarii, BRAF mutation ovarian cancer, NGS ovarian tumor.

Clinical Management implications: A Conservative Approach

The recognition of NIFTP within struma ovarii has lead to a more conservative surgical approach. For encapsulated tumors meeting NIFTP criteria, complete surgical resection is generally sufficient.

* Avoidance of Total Thyroidectomy: Unlike conventional papillary thyroid carcinoma, prophylactic total thyroidectomy is not recommended for NIFTP within struma ovarii.

* **Radio

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