The research showed that not only had the patient suffered from pneumonia, but that the inflammation affected the entire endothelium of various organs, the university said. The pathologist Varga also succeeded in the direct detection of SARS-CoV-2 in the endothelium and the cell death triggered there by the virus. The authors conclude that the new coronavirus also penetrates human cells via the ACE2 receptors found in the endothelium and leads to generalized inflammation of the endothelium, endotheliitis. This affects all vascular beds in the body: heart, brain, lung and kidney vessels as well as vessels in the intestinal tract. The consequences are severe microcirculation disorders that damage the heart, trigger pulmonary embolism and vascular occlusions in the brain and intestinal tract, and could lead to multi-organ failure and even death.
