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Covid-19 virus

The Current COVID-19 Situation in America: Updates from Assoc.Prof.Dr.Theera Worathanarat

by archyde August 20, 2023

written by archyde

2023-08-20 00:24:00

On August 20, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Theera” Faculty of Medicine Chulalongkorn University Facebook post updates the issue. “COVID-19” stating that

situation in america

Weiland J presents an assessment of the COVID-19 situation in America, showing that it is on a clear uptrend. It is estimated that there are regarding 600,000 new infections per day.

However, data from the US CDC estimated the proportion of endemic strains, found that EG.5 was the highest at 20.6%, while FL.1.5.1 followed at 13.3%, while XBB.1.16 and XBB.2.3 were found around 10%.

Due to the large number of mutational loci of BA.2.86, it differs greatly from XBB and BA.2 worldwide, it remains vigilant. and follow up on how much the outbreak will spread At present, there are still reports in 6 cases in 4 countries.

The name of the Greek letter. will occur when there is a large outbreak The disease is so severe that it affects the public health system. Or it has been found that mutations significantly reduce vaccine efficacy.

The next Greek letter following Omicron is Pi, but for some reason Nu and Xi are skipped. It will be the letter Rho.

recurrent infection not good

Data from the US CDC published in MMWR in June 2023 presents the results of a survey from 2021-2022.

This indicates that reinfection rates in the US population have been steadily rising since 2.7% during the Delta outbreak around late 2021 and climbing to 10.3% during Omicron BA.1.

and increased to 12.5% over BA.2, 20.6% over BA.4/BA.5 and jumping to almost a third (28.8%) over BQ.1/BQ.1.1.

The age range with the greatest increase in re-infection was between the ages of 18 and 49, which was between school and working age.

Current medical knowledge is clear that each infection is accompanied by a risk of illness, death, and also the risk of a long-term disorder like Long COVID that will impair long-term quality of life. Symptoms can occur in almost every system of the body. and various chronic diseases such as diabetes, autoimmune diseases, etc.

daily use Should be aware of the situation that the epidemic is still ongoing, should not be careless, always protect oneself beware of crowded poor ventilation wearing a mask correctly It will greatly reduce the risk.

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#Theera #reveals #America #upward #phase #expected #cases #COVID19 #day

August 20, 2023 0 comments

Health

The Impact of COVID-19 on the Brain: Long-Term Neurological Effects and Mechanisms

by archyde August 13, 2023

written by archyde

2023-08-12 23:47:00

On August 13, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Theera” Faculty of Medicine Chulalongkorn University Facebook post updates the issue. “COVID-19” stating that

The COVID-19 virus and the brain

It is well known today that the infectionCOVID-19 virus or SARS-CoV-2 is not only infectious in the respiratory system but can spread to almost every system in the body It has been proven by research from around the world.

Not many patients following recovering from the initial infection back with persistent abnormalities or reappear following recovering from illness and is continuing in the long run known as Long COVID or Post-COVID conditions

Symptoms that occur in the long run occur in every system in the body by resulting in illness impair performance in daily life worsen the quality of life Both in school, work and personal life. Including various expenses It is a burden on patients, families and society.

common symptoms There are both tired and exhausted things. muscle and joint pain including problems in the vital systems of the body both heart and blood vessels respiratory system digestive system urinary system And very important is the brain and nervous system. Which usually comes with problems with concentration, emotions, thoughts, memory, etc.

Mechanisms that cause abnormalities in Long COVID occur from many mechanisms, such as the presence of the virus or its fragments remaining in the body’s organs, the tissues or cells in that system. Destroyed by viruses, autoimmunity, infections provoke chronic inflammatory processes, including infection with COVID-19. Encourage infectious viruses that are hidden in the body to become active, etc.

One of the studies definitively proved that viral fragments remain in the brain following infection.COVID-19 It comes from a German research team. The study was published in bioRxiv last April. by detecting the cortical fragments of the virus both in the brain bone marrow of the skull and the cortex from the bodies of patients who died from COVID-19 About half of the total which led to the medical hypothesis that

The remains of the virus especially in the marrow part of the skull It is likely to lead to inflammation. interfere with brain function and/or destroy nerve cells in the brain This will cause problems with brain and nervous system abnormalities in Long COVID patients.

The German team conducted further studies and proposed that the above mechanisms might be used to explain brain and nervous system problems from other diseases. that are similar as well It was published in the medical science journal Cell on August 9th.

protection once morest infection or not repeating is the best

Live a conscious life, don’t be careless, always protect yourself.

wearing a mask correctly It will greatly reduce the risk.

refer

1. SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19. bioRxiv. 5 April 2023.

2. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 9 August 2023.

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#Thira #updated #COVID19 #brain #causing #problems #concentration #emotions #thoughts #memory

August 13, 2023 0 comments

Health

COVID-19 Update: Latest Trends and Metformin Treatment for Long COVID Prevention

by archyde June 10, 2023

written by archyde

2023-06-10 01:29:00

On June 10, 2023 Assoc. Prof. Dr. Thira Worathanarat or “Doctor Thira“Faculty of Medicine Chulalongkorn University Facebook post regarding the issue “COVID-19“Indicates that update knowledge of COVID-19

COVID-19 strains epidemic in America

Data from the US CDC up to 10 June 2023 assessed that Omicron subspecies XBB.1.5 Still occupying the proportion of the main epidemic at 39.9%, with a continuous downward trend.

while the subspecies XBB.1.16 increased to 18.2%, with a tendency to continue to increase as well

The next one is XBB.1.9.1 at 12.5%.

followed by XBB.1.16.1 and XBB.1.9.2, which were found in the same proportion of 8.4%.

and XBB.2.3, another variant under Monitoring (VUM) that the World Health Organization monitors, was also found at 6%.

the above characteristics Suffice it to point out the trend of species change in America. That should be more similar to Australasia in the coming quarters.

Some scientists, such as Weiland JP, have estimated that this might result in more hospitalizations in the US as well, with increases in 1.16.x, 1.9.x, 2.3.

Metformin for COVID-19 Treatment and Long COVID Prevention

According to research published in the New England Journal of Medicine last year, it reduced the risk of getting sick to the emergency department. hospital stay and death was approximately 42% (confidence range from 6%-65%).

Most recently, research published in The Lancet Infectious Diseases two days ago. Metformin was also studied and found to reduce the viral load in the blood. And most importantly, it can reduce the risk of Long COVID by regarding 40% by the incidence rate.Long COVID problem At 300 days following infection It was 10.4% in the drug-free group, while 6.3% in the drug-treated group.

If you calculate the Number needed to treat, it will be regarding 25, meaning that if you use the drug for 25 people, it will reduce the risk of Long COVID for 1 person.

The research above was studied in a population aged 30-85 years who were obese. or overweight Having a body mass index (BMI) of 25 or higher

The dose used is Metformin (500 mg) 1 tablet on the first day, then increased to 1 tablet twice a day. From day 2-5, continue with 1 morning pill and 2 evening pills for 14 days. The drug should be started within 3 days following the onset of illness.

However, the limitation of the above study results is It cannot be used for other populations under 30 years of age, including people with normal body weight. or have a body mass index less than 25

Metformin is now of interest to medical professionals around the world. Because there is standard research data that proves the properties step by step and the price is cheap, although the mechanism explaining the properties is still unclear. But laboratory data suggests that the drug inhibits the replication of the disease virus.COVID-19 which suggests that this mechanism may play a role in reducing the risk of severe illness and reducing the risk of Long COVID

refer

1. Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. NEJM. 18 August 2022.

2. Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial. The Lancet Infectious Diseases. 8 June 2023.

3. Covid-19: Metformin reduces the risk of developing long term symptoms by 40%, study finds. BMJ. 8 June 2023.

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#Theera #updates #COVID19 #America #strain #XBB.1.5 #decrease

June 10, 2023 0 comments

Health

‘Dr. Thira’ reveals that the world has been infected with ‘COVID-19’, adding 45,602 people, 132 more deaths.

by archyde April 2, 2023

written by archyde

“Mr. Thira” around the world infected with “Covid-19”, adding 45,602 people, 132 more deaths, revealing the top 5 most infected: Russia, South Korea, France, Japan and Chile.

On April 2, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Thira“Faculty of Medicine Chulalongkorn University Facebook post regarding the issue “COVID-19” indicates that

Yesterday, around the world, there were 45,602 more infections, 132 more deaths, a total of 683,991,820 people, and a total of 6,831,892 deaths.

The top 5 most infected with “COVID-19” are

Russia
South Korea
France
Japan
Chile

As of yesterday, in the number of new infections, countries from Europe and Asia occupied eight of the top 10 and 18 of the top 20 globally.

The number of new infections per day around the world right now from Asia and Europe Together, it accounted for 92.3 percent of the world, while the number of deaths accounted for 92.42 percent.

Update Meeting on Long COVID

in April The World Health Organization will host a webinar “Expanding our understanding of post COVID-19 condition web series: the evolving research landscape” to update the latest academic knowledge on Long COVID.

Which will be held on April 11, 13.30-15.30 (CET) or 18.30-20.30 Thailand time

There will be experts from around the world to present information and knowledge. from the UK, Belgium, Argentina and the USA

Covid-19 virus

The Current COVID-19 Situation in America: Updates from Assoc.Prof.Dr.Theera Worathanarat

The Impact of COVID-19 on the Brain: Long-Term Neurological Effects and Mechanisms

COVID-19 Update: Latest Trends and Metformin Treatment for Long COVID Prevention

‘Dr. Thira’ reveals that the world has been infected with ‘COVID-19’, adding 45,602 people, 132 more deaths.

“Mr. Thira” around the world infected with “Covid-19”, adding 45,602 people, 132 more deaths, revealing the top 5 most infected: Russia, South Korea, France, Japan and Chile.

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