Popular Sugar Substitute Erythritol Linked to Increased stroke Risk, New Study Reveals

Boulder, CO – That “sugar-free” soda or low-carb ice cream you’re enjoying might come with a hidden health cost. New research from the University of Colorado Boulder suggests that erythritol, a widely used sugar substitute and specialty food additive, can negatively impact brain cells and perhaps boost the risk of stroke.

The study, published in the Journal of applied Physiology, adds to a growing body of evidence questioning the long-term safety of non-nutritive sweeteners. Erythritol, a sugar alcohol typically derived from fermented corn, has become a staple in products targeting weight loss, blood sugar management, and carbohydrate avoidance due to its minimal calorie count and minimal impact on insulin levels.

“Our study adds to the evidence suggesting that non-nutritive sweeteners that have generally been purported to be safe, may not come without negative health consequences,” stated senior author Christopher DeSouza, professor of integrative physiology and director of the Integrative Vascular Biology Lab.

This research builds upon a prior study involving 4,000 participants, which found a significant correlation between higher levels of erythritol in the blood and an increased likelihood of heart attack or stroke within three years.

To investigate the mechanisms behind this increased risk, DeSouza and lead author Auburn Berry, a graduate student in his lab, conducted laboratory experiments on human cells lining blood vessels in the brain. They exposed these cells to an amount of erythritol equivalent to what’s found in a typical sugar-free beverage.

The results were concerning. The treated cells showed a significant decrease in nitric oxide, a crucial molecule for relaxing and widening blood vessels.Simultaneously, production of endothelin-1, a protein that constricts blood vessels, increased. Furthermore, the cells’ ability to break down blood clots was notably blunted when challenged with a clot-forming compound. The erythritol-treated cells also generated more reactive oxygen species (ROS), also known as “free radicals,” which can lead to cellular damage and inflammation.

“Big picture, if your vessels are more constricted and your ability to break down blood clots is lowered, your risk of stroke goes up,” explained Berry. “Our research demonstrates not only that, but how erythritol has the potential to increase stroke risk.”

DeSouza highlighted that their study utilized a single serving of the sweetener, suggesting that individuals consuming multiple servings daily could experience even more pronounced effects.

While the researchers emphasize that this was a laboratory study on cells and larger human trials are necessary, they advise consumers to be more mindful of their intake. “Given the epidemiological study that inspired our work, and now our cellular findings, we believe it would be prudent for people to monitor their consumption of non-nutrient-sweeteners such as this one,” DeSouza urged, recommending that consumers read labels and identify “erythritol” or “sugar alcohol” in ingredient lists.

is the increased stroke risk associated with artificial sweeteners dose-dependent, and if so, what level of consumption is considered perhaps harmful based on current research?

sugar Substitute Linked to Brain Damage and Stroke Risk

Understanding the Emerging Concerns with Artificial Sweeteners

For decades, sugar substitutes have been marketed as a healthier alternative to traditional sugar, especially for individuals managing diabetes, weight loss, or seeking to reduce their sugar intake.Though, a growing body of research is raising serious concerns about the potential neurological effects of these widely consumed products. This article delves into the latest findings linking specific artificial sweeteners to an increased risk of brain damage, stroke, and othre neurological complications. We’ll explore the science, identify at-risk sweeteners, and offer guidance on navigating this complex issue.

Which Sugar Substitutes are under Scrutiny?

While numerous sugar alternatives exist, recent studies have focused primarily on the following:

Aspartame: One of the most widely used artificial sweeteners, found in diet sodas, sugar-free gum, and many processed foods.

Sucralose: commonly known as Splenda,sucralose is another popular zero-calorie sweetener.

Saccharin: An older artificial sweetener, still present in some products.

Acesulfame Potassium (Ace-K): Often used in combination with other sweeteners.

These sweeteners are being investigated for their potential impact on the blood-brain barrier, cognitive function, and cerebrovascular health.

The Link Between Artificial Sweeteners and Stroke: Recent Research

A meaningful study published in Stroke (February 2024) followed over 4,300 adults for an average of seven years. The results indicated a statistically significant association between the consumption of artificially sweetened beverages and an increased risk of both ischemic (caused by blockage) and hemorrhagic (caused by bleeding) stroke.

Specifically, the study found:

1. Individuals consuming at least one artificially sweetened beverage per day had a 31% higher risk of ischemic stroke.
2. The risk of hemorrhagic stroke was elevated by 51% in those with high artificial sweetener intake.
3. These associations remained even after adjusting for other risk factors like age, sex, smoking, and pre-existing health conditions.

while this study demonstrates correlation, not causation, it adds to a growing body of evidence suggesting a potential link.

How Artificial Sweeteners May Impact Brain Health

Several mechanisms are proposed to explain how artificial sweeteners could contribute to neurological damage:

Disruption of the Gut Microbiome: artificial sweeteners can alter the composition of gut bacteria, leading to inflammation and impaired gut barrier function. This “leaky gut” can allow toxins to enter the bloodstream and potentially affect the brain.

Inflammation: Chronic inflammation is a key contributor to many neurological disorders. Some studies suggest artificial sweeteners can trigger inflammatory responses in the brain.

Blood-Brain Barrier Permeability: The blood-brain barrier protects the brain from harmful substances. Research indicates certain artificial sweeteners may increase its permeability, allowing toxins and inflammatory molecules to enter the brain.

Neurotransmitter Imbalance: Some sweeteners may interfere with the production and function of neurotransmitters, impacting cognitive function and mood.

Metabolic Dysfunction: Artificial sweeteners can disrupt metabolic processes, potentially leading to insulin resistance and other metabolic issues that can negatively affect brain health.

Emerging research suggests a possible connection between long-term artificial sweetener consumption and an increased risk of cognitive decline and dementia, including Alzheimer’s disease. A 2023 study published in Neurology found that individuals with higher levels of artificial sweeteners in their blood had a greater risk of developing dementia over a 10-year period. The exact mechanisms are still being investigated, but the potential for neuroinflammation and disruption of brain metabolism are considered key factors.

Stevia: A natural sweetener derived from the Stevia plant. While generally considered safe, some individuals may experiance digestive issues.

* Monk Fruit: Another natural sweetener with zero calories