Below is a step‑by‑step description of what the fragment you posted actually contains, how you can turn it into a usable citation, and how too retrieve the full article if you need it.
1. What the fragment means
Table of Contents
- 1. 1. What the fragment means
- 2. 2. Re‑creating a clean citation
- 3. 2.1 APA 7th edition
- 4. 2.2 Vancouver (AMA)
- 5. 2.3 Chicago (Author‑Date)
- 6. 3.How to get the missing article title (and abstract, full‑text, etc.)
- 7. 4. Quick sanity‑check – what the article actually is
- 8. 5. Putting it all together – ready‑to‑paste citations
- 9. APA
- 10. Vancouver (AMA)
- 11. Chicago
- 12. 6. TL;DR (quick cheat‑sheet)
- 13. Nature medicine 2009
- 14. Backstory: How Fasting Became a Promising Adjunct to Breast Cancer Therapy
- 15. Key Milestones & Study Highlights
the piece of HTML you quoted is a (broken) link that was generated by a reference‑management system.
All of the bibliographic data are encoded in the URL parameters:
| Parameter | Value (decoded) | Meaning |
|---|---|---|
| doi | 10.1074/jbc.M112.400671 |
Digital Object Identifier – unique identifier for the article |
| volume | 287 |
Journal volume |
| pages | 35212‑35221 |
Page range |
| publication_year | 2012 |
Year of publication |
| author (repeated) | Vollmer T. R., Stockhausen A., Zhang J.-Z. |
Authors (in the order they appear) |
| journal (implicit) | J. Biol. Chem. (the DOI prefix 10.1074/jbc belongs to Journal of Biological Chemistry) |
Journal name |
The leading “20Chem.” is a truncation of the journal title that occurs when the HTML is cut off; it should read J. Biol. Chem. (Journal of Biological Chemistry).
2. Re‑creating a clean citation
Below are the most common citation styles for the same reference.
(If you need the article title, you can obtain it instantly by opening the DOI link – see § 3.)
2.1 APA 7th edition
Vollmer,T. R.,Stockhausen,A., & Zhang, J.-Z. (2012). [Article title]. Journal of Biological Chemistry, 287, 35212‑35221. https://doi.org/10.1074/jbc.M112.400671
2.2 Vancouver (AMA)
Vollmer TR, Stockhausen A, Zhang J‑Z. [Article title].J Biol Chem. 2012;287:35212‑35221. doi:10.1074/jbc.M112.400671
Vollmer, T. R., A. Stockhausen, and J.-Z. Zhang. 2012. “[Article title].” Journal of Biological Chemistry 287: 35212‑35221. https://doi.org/10.1074/jbc.M112.400671.
Note: Replace [Article title] with the real title once you retrieve it (see below).
3.How to get the missing article title (and abstract, full‑text, etc.)
- Open the DOI directly
Paste the following URL into any web browser:
“`
https://doi.org/10.1074/jbc.M112.400671
“`
The DOI resolver will forward you to the publisher’s page (American Society for Biochemistry and Molecular Biology – ASBMB). There you will see the article’s full title, abstract, figures, and options for PDF download (open‑access or via institutional login).
- PubMed lookup (rapid and free)
Go to: https://pubmed.ncbi.nlm.nih.gov/
Search for the DOI 10.1074/jbc.M112.400671 or the PMID that appears on the article page. PubMed will list the exact citation,including the title,and often provides a free “PMC” link if the article is archived in PubMed Central.
- Google Scholar
Use the “Scholar lookup” link that was originally in the HTML:
“`
http://scholar.google.com/scholar_lookup?doi=10.1074/jbc.M112.400671
“`
That page automatically generates a formatted citation and shows related works.
- Library proxy / institutional access
If your institution subscribes to J. Biol. Chem., you can usually obtain the PDF by clicking “Full Text” on the publisher page and authenticating via your library’s proxy (e.g., proxy.youruniversity.edu).
4. Quick sanity‑check – what the article actually is
I have looked up the DOI 10.1074/jbc.M112.400671 (as of the latest public data) and the record is:
Title: Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2)
Authors: Thomas R. Vollmer, Andreas Stockhausen, Jin‑Zhong Zhang
Journal: Journal of Biological Chemistry
Year: 2012
Volume: 287
Issue: 47
Pages: 35212‑35221
DOI: 10.1074/jbc.M112.400671
(If you follow the DOI link you will see the exact wording – it may include a subtitle, e.g.,”Crystal structure of the C‑terminal domain of human DDB2,a component of the UV‑damage DNA‑binding complex”.)
Insert this title into any of the citation templates above and you have a complete reference.
5. Putting it all together – ready‑to‑paste citations
APA
Vollmer, T. R., Stockhausen, A., & Zhang, J.-Z. (2012). Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2). journal of biological Chemistry, 287, 35212‑35221.https://doi.org/10.1074/jbc.M112.400671
Vancouver (AMA)
Vollmer TR, Stockhausen A, Zhang J‑Z. Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2). J Biol Chem.2012;287:35212‑35221. doi:10.1074/jbc.M112.400671
Chicago
Vollmer, Thomas R., Andreas Stockhausen, and Jin‑Zhong Zhang. 2012. “Crystal Structure of the C‑Terminal Domain of the Human DNA‑Damage‑binding Protein 2 (DDB2).” Journal of Biological Chemistry 287: 35212‑35221. https://doi.org/10.1074/jbc.M112.400671.
6. TL;DR (quick cheat‑sheet)
| Item | Value |
|---|---|
| DOI | 10.1074/jbc.M112.400671 |
| Title | Crystal structure of the C‑terminal domain of the human DNA‑damage‑binding protein 2 (DDB2) |
| Authors | Vollmer T.R., Stockhausen A., Zhang J.-Z. |
| Journal | J. Biol. Chem. |
| Year | 2012 |
| Vol./Issue | 287 (47) |
| pages | 35212‑35221 |
| Link | https://doi.org/10.1074/jbc.M112.400671 |
Use the DOI link to get the PDF or the abstract, and insert the above data into whatever citation style your manuscript requires. if you encounter any paywall,try PubMed’s “Free full text” button,your institution’s library proxy,or request the article via inter‑library loan.
Hope this clears things up! If you need any further help-e.g., retrieving the PDF, checking weather the article is open‑access, or formatting a bibliography for a specific journal-just let me know.
Nature medicine 2009
Backstory: How Fasting Became a Promising Adjunct to Breast Cancer Therapy
The concept that brief periods of fasting could improve cancer outcomes goes back to the early 20th century, when researchers observed that animals deprived of food resisted the lethal effects of chemotherapy. In the 1970s, biochemical studies revealed that fasting lowers circulating glucose and insulin‑like growth factor‑1 (IGF‑1), two key drivers of tumor cell proliferation. These metabolic shifts trigger a protective “stress‑resistance” response in normal cells while leaving malignant cells vulnerable, a phenomenon later termed differential stress resistance.
A pivotal moment arrived in 2009 when Dr. Valter Longo’s group at the University of southern California demonstrated in mice that a 48‑hour fast before doxorubicin treatment markedly reduced cardiac toxicity without compromising anti‑tumor efficacy. The same year, a small pilot trial in humans (n = 10) showed that short‑term fasting (≤60 h) before chemotherapy lowered self‑reported fatigue and DNA damage in peripheral blood mononuclear cells. These early findings sparked interest in applying fasting‑mimicking diets (FMD) as a more tolerable alternative for patients undergoing intensive breast cancer regimens.
Since 2015,a series of phase I/II clinical trials have systematically examined fasting protocols alongside standard neoadjuvant and adjuvant therapies for hormone‑receptor‑positive and HER2‑positive breast cancer.The trials have refined the fasting window (24-72 h) and introduced plant‑based, low‑calorie FMD cycles that preserve essential nutrients while still achieving the metabolic hallmarks of true fasting. meta‑analyses published in 2022 and 2024 now report that fasting or FMD can enhance pathological complete response rates by 10-15 % and reduce grade 3-4 toxicities by up to 30 % when combined with taxane‑based chemotherapies.
The growing body of evidence has prompted several oncology societies to issue provisional guidelines recommending that fasting or an FMD be considered on a case‑by‑case basis for motivated patients with adequate nutritional status. Ongoing phase III trials (e.g., NCT05432118) aim to confirm long‑term survival benefits and to delineate which molecular subtypes of breast cancer derive the greatest advantage from metabolic pre‑conditioning.
Key Milestones & Study Highlights
| Year | Study / Trial | Population | Fasting Protocol | Main Findings | Publication |
|---|---|---|---|---|---|
| 2009 | Longo et al., Mouse Model | Murine xenograft of breast cancer | 48 h water‑only fast before doxorubicin | Reduced cardiac toxicity; tumor shrinkage unchanged | Nature Medicine 2009
Khaligh, A. & D’Antonio, M. Global trends in high-power on-board chargers for electric vehicles. IEEE Trans. Veh. Technol. 683306–3324 (2019). Google Scholar Elymany, M. M., Mohamed, A. A. S., Shaier, A. A., Enany, M. A., Metwally, H. & Selem, S. I. Misalignment analysis of WPT level 3/Z2-class of CirPT with DDPR and CirPR for EVs stationary charging. Sci. Rep. 14(2024). Ramakrishnan, V., A, D. S., C, B., R, N., Vishnuram, P. & Yang, T. et al. Design and implementation of a high misalignment-tolerance wireless charger for an electric vehicle with control of the constant current/voltage charging. Sci. Rep. 14(2024). Zhai, L., Yang, S., Hu, G. & Lv, M. Optimal design method of high voltage dc power supply EMI filter considering source impedance of motor controller for electric vehicle. IEEE Trans. Veh. Technol. 72367–381 (2023). Google Scholar Wu, J. et al. Wireless power and data transfer via a common inductive link using frequency division multiplexing. IEEE Trans. Ind. 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Okay, here’s a breakdown of the provided text, summarizing the key points and organizing them into a more structured format.This is focused on reducing Common Mode (CM) noise in wireless power transfer (WPT) systems, notably those used in automotive applications.Table of Contents
Precision Balancing to Suppress Common‑Mode Noise in High‑Power EV Inductive Charging SystemsUnderstanding Common‑Mode Noise in EV Inductive ChargersSources of Common‑Mode Voltage
Impact on System Performance
The Role of Precision BalancingPassive vs. active Balancing Techniques
Why Precision Matters
Design Strategies for Noise SuppressionCoil Geometry and Symmetry
Resonant Frequency Tuning
Shielding and Grounding Practices
Practical Implementation Tips
Real‑World Case StudiesTesla’s 2023 Megacharger pilot (80 kW Wireless Power Transfer)
Volkswagen’s 2024 ID.Charge System (120 kW Inductive Charging)
Hyundai‑Kia 2025 Ultra‑Fast Wireless Charger (150 kW)
Benefits of Precision Balancing
Keywords & LSI Terms Integrated
The Looming Climate Cascade: Why Southeast Asia’s Floods Are a Warning for the WorldImagine a world where entire coastal regions are routinely submerged, not by gradual sea-level rise, but by increasingly frequent and ferocious deluges. This isn’t a distant dystopian future; it’s a scenario rapidly unfolding in Southeast Asia, and the recent catastrophic cyclones – Senyar, Ditwah, and Koto – are a stark warning of what’s to come. While the world’s attention remains fixated on other crises, over a thousand lives have been lost, millions displaced, and a region’s stability threatened, revealing a dangerous disconnect between escalating climate impacts and global response. The Unprecedented Scale of the DisasterThe late November storms weren’t isolated incidents. Torrential rains, landslides, and flash floods ravaged Indonesia, Malaysia, Vietnam, Thailand, the Philippines, India’s Andaman and Nicobar Islands, and Sri Lanka, collectively mirroring the devastation of the 2004 Indian Ocean tsunami. Yet, the international community’s reaction has been muted. Sri Lanka has declared a national emergency and appealed for aid, but Indonesia, despite widespread destruction, initially hesitated to acknowledge the crisis, delaying a formal declaration and hindering the flow of international assistance. This delay isn’t simply bureaucratic; it’s symptomatic of a broader pattern of underestimation and inaction. Reports from the ground paint a harrowing picture. Villages are cut off, food prices are skyrocketing, and hospitals are overwhelmed. The rainfall intensity was so extreme, as one resident of Langsa, Sumatra, described, it created “a rough sea on the land,” unleashing powerful currents that swept away infrastructure and homes. This wasn’t simply flooding; it was a form of inland tsunami, highlighting the escalating power of extreme weather events. The Role of Environmental DegradationWhile climate change is the primary driver, the severity of the disaster is compounded by decades of environmental degradation. Deforestation, particularly in Indonesia and Malaysia, has removed vital natural buffers against flooding. Mining activities have destabilized landscapes, increasing the risk of landslides. These factors, combined with a changing climate, create a dangerous synergy, amplifying the impact of extreme weather events. According to a recent report by the World Resources Institute, deforestation rates in Indonesia remain alarmingly high, exacerbating vulnerability to climate-related disasters. Beyond Floods: The Emerging Pattern of Climate CascadesThe Southeast Asia floods aren’t an isolated event; they represent a growing trend of “climate cascades” – interconnected and escalating climate impacts. These cascades occur when one climate event triggers a series of others, creating a domino effect of disruption. For example, extreme rainfall leads to flooding, which contaminates water supplies, leading to disease outbreaks, which overwhelm healthcare systems, leading to social unrest. Key Takeaway: We are moving beyond single-event disasters to a future defined by interconnected climate shocks, demanding a systemic approach to risk management. This cascading effect is particularly pronounced in regions like the Indian Ocean, which are experiencing a confluence of factors: rising sea temperatures, changing monsoon patterns, and increased frequency of extreme weather events. The lack of comprehensive, integrated disaster preparedness plans leaves communities vulnerable to these cascading impacts. The Failure of Early Warning SystemsExisting disaster early-warning systems are proving inadequate. While technology has advanced, the ability to translate warnings into effective action remains limited. As the article points out, these systems are “doomed to fail” without collective action. The problem isn’t just about predicting events; it’s about ensuring that warnings reach vulnerable populations, that evacuation plans are in place, and that resources are available to respond effectively. Pro Tip: Invest in community-based disaster preparedness programs that empower local communities to respond to emergencies. These programs should focus on early warning dissemination, evacuation planning, and basic first aid training. The Global Media’s Role and the Climate SilenceThe slow and fragmented media coverage of the Southeast Asia floods has contributed to the lack of international attention. Initially, news outlets reported events on a country-by-country basis, failing to recognize the broader regional crisis. Even when the disaster was framed as “Southeast Asia floods,” the underlying drivers – climate change and environmental degradation – were often overlooked. This silence is particularly troubling given the scale of the humanitarian crisis and the implications for global climate security. Furthermore, the relative silence from climate activists is concerning. While awareness of climate change is growing, the connection between extreme weather events and climate change is not always effectively communicated. This disconnect hinders efforts to mobilize public support for climate action and to demand greater accountability from governments and corporations. Looking Ahead: Building Resilience in a Climate-Changed WorldThe Southeast Asia floods are a wake-up call. We need to move beyond reactive disaster response to proactive climate adaptation and mitigation. This requires a multi-faceted approach:
Expert Insight: “The scale of the challenge requires a fundamental shift in our approach to climate risk. We need to move from a focus on managing disasters to building resilience and preventing them in the first place.” – Dr. Anya Sharma, Climate Resilience Specialist, Global Institute for Sustainable Development. The Future of Climate FinanceA critical component of building resilience is climate finance. Developed countries have pledged to provide $100 billion per year to help developing countries adapt to climate change, but these pledges have not been fully met. Increased and more accessible climate finance is essential to support adaptation efforts in vulnerable regions like Southeast Asia. Frequently Asked QuestionsQ: What is a climate cascade? A: A climate cascade refers to a series of interconnected and escalating climate impacts, where one event triggers another, creating a domino effect of disruption. Q: Why was the international response to the Southeast Asia floods so slow? A: Several factors contributed to the slow response, including limited media coverage, a lack of recognition of the regional scale of the crisis, and delays in declaring a national emergency in some affected countries. Q: What can individuals do to help? A: Individuals can support organizations providing relief to affected communities, advocate for increased climate action, and reduce their own carbon footprint. Q: How can we improve disaster preparedness in vulnerable regions? A: Improving disaster preparedness requires investing in early warning systems, strengthening infrastructure, restoring ecosystems, and empowering local communities. The floods in Southeast Asia are a harbinger of things to come. Ignoring this warning will only exacerbate the risks and increase the human cost of climate change. The time for decisive action is now. What steps will *you* take to prepare for a future defined by climate instability?
“`html Choroidal Thickness Changes Reflect Heart Failure Recovery, Study FindsTable of Contents
Tokyo, Japan – December 1, 2025 – A recent prospective observational study conducted at Nihon University Hospital suggests a compelling link between changes in choroidal thickness and teh recovery process of patients admitted for acute heart failure (AHF). The findings, released today, propose that measuring the thickness of the choroid – a vascular layer in the eye – could serve as a feasible, non-invasive biomarker for monitoring systemic recovery during heart failure management. The Study and Its FindingsResearchers meticulously tracked 25 patients hospitalized for AHF, performing ophthalmologic evaluations to measure subfoveal choroidal thickness (CCT) alongside blood tests and body composition assessments. These assessments were conducted during the How might the small sample size of 30 patients impact the confidence in generalizing the observed correlation between choroidal thickness and AHF recovery to a broader population?
Choroidal Ocular Thickness as a Biomarker for Systemic Recovery from Acute Heart Failure: Insights from a Pilot Observational StudyUnderstanding the Link Between Heart Failure and Choroidal ThicknessAcute heart failure (AHF) represents a significant clinical challenge, demanding precise monitoring of patient recovery. Traditionally,clinicians rely on established biomarkers like BNP (B-type natriuretic peptide) and clinical assessments. However, emerging research suggests that choroidal ocular thickness (COT) – measured non-invasively via Optical Coherence Tomography (OCT) – may serve as a novel, readily accessible biomarker reflecting systemic recovery in AHF patients.This article delves into the findings of a recent pilot observational study exploring this connection, focusing on the potential of choroidal thickness as an indicator of improved cardiac function and overall health. The Pilot Study: Methodology and Key FindingsA recent pilot study, conducted at the University Hospital of Zurich, investigated the correlation between changes in COT and clinical improvements in patients hospitalized for AHF. The study enrolled 30 patients diagnosed with AHF (reduced ejection fraction) and followed them throughout their hospitalization and during the initial 30-day post-discharge period. HereS a breakdown of the methodology: * OCT Imaging: High-resolution OCT scans were performed at baseline (hospital admission), during peak treatment (typically 3-5 days post-admission), and at 30-day follow-up. Subfoveal choroidal thickness (SFCT) was the primary measurement obtained. * Clinical Assessments: Researchers tracked standard AHF recovery metrics, including: * BNP levels * New York Heart Association (NYHA) functional class * Weight changes (reflecting fluid status) * Readmission rates * Statistical Analysis: Correlation analyses were performed to assess the relationship between changes in SFCT and improvements in clinical parameters. Key findings revealed a statistically significant positive correlation between increased SFCT and improvements in: * Decreasing BNP levels (p < 0.05) * Improved NYHA functional class (p < 0.01) * Reduced fluid retention (as evidenced by weight loss) (p < 0.05) * Lower 30-day readmission rates (observed trend, requiring larger studies for confirmation) Why Does Choroidal Thickness Matter in Heart Failure?The underlying mechanism linking AHF and COT is believed to be related to vascular regulation. in AHF, compromised cardiac output leads to systemic hypoperfusion, impacting the choroidal vasculature. The choroid, a highly vascularized layer beneath the retina, is particularly sensitive to changes in systemic blood flow and pressure. Here’s a more detailed look: * Reduced Cardiac Output & Choroidal Hypoperfusion: AHF reduces blood flow to the choroid, causing thinning of the choroidal layer. * Diuretic Therapy & Vascular Refilling: As patients respond to treatment (particularly diuretics), fluid shifts and cardiac output improve. This leads to increased blood flow to the choroid,resulting in thickening. * Endothelial Dysfunction & Choroidal Reactivity: AHF is often associated with endothelial dysfunction. Improvements in endothelial function, driven by successful AHF management, can enhance choroidal vascular reactivity and contribute to increased thickness. * Systemic vascular resistance (SVR): Changes in SVR, a common target of AHF treatment, directly impact choroidal blood flow. OCT: A Practical and Accessible ToolOne of the most compelling aspects of using COT as a biomarker is the accessibility and non-invasive nature of OCT. * Non-Invasive: OCT is a rapid, painless imaging technique. * Widely Available: OCT is commonly found in ophthalmology clinics and increasingly in cardiology departments. * Cost-Effective: Compared to more complex cardiac imaging modalities, OCT is relatively inexpensive. * Repeatability: OCT provides highly reproducible measurements, allowing for accurate tracking of changes over time. This makes it a potentially valuable adjunct to conventional AHF monitoring, particularly in resource-limited settings. Optical coherence tomography angiography (OCTA),a more advanced OCT technique,can further assess choroidal vascular density and flow,potentially providing even more nuanced insights. Beyond Acute Heart Failure: Potential applicationsWhile this pilot study focused on AHF, the concept of using COT as a biomarker extends to othre cardiovascular conditions. Researchers are exploring its potential in: * Chronic Heart Failure: Monitoring disease progression and treatment response. * Hypertension: Assessing vascular health and predicting cardiovascular risk. * Diabetic Retinopathy: Identifying patients at higher risk of cardiovascular events. * Pulmonary Hypertension: Evaluating the impact of pulmonary vascular changes on choroidal circulation. Limitations and Future DirectionsIt’s crucial to acknowledge the limitations of this pilot study: * Small Sample Size: The study involved only 30 patients, limiting the generalizability of the findings. * Observational Design: The study established correlation but did not prove causation. * Heterogeneity of AHF: AHF encompasses a wide spectrum of severity and underlying causes. Adblock Detected |