It’s quite an amusing story, actually. I was having a bowl of instant noodles and observed how the noodles separate in the broth. That simple observation sparked the idea of small DNA fragments circulating in a liquid medium, leading me to hypothesize about the presence of fetal DNA in maternal plasma.Transforming Prenatal Care

Your discovery led to the development of the T21 test, a non-invasive blood test for Down syndrome screening. How did you feel when you first saw the potential of your research in transforming prenatal care?

Professor Dennis lo: I was thrilled and humbled, to be honest. To think that something I first visualized while eating instant noodles could have such a profound impact on the lives of expectant parents worldwide was truly astonishing.

Can you tell our readers about the advancements derived from your initial discovery? How are they applied beyond prenatal diagnostics?

Professor Dennis Lo: My research has opened up new avenues for using cell-free nucleic acids, both DNA and RNA, for various diagnostic purposes. Currently, we’re exploring their use in early detection and monitoring of conditions like cancer and neurodegenerative diseases, as well as for studying epigenetic aging.

A world Impact

The T21 test is now available in over 90 countries, making it more accessible to a broader patient population.Can you share any inspiring stories or testimonials you’ve received from parents who have benefited from your work?

Professor Dennis Lo: I’ve heard heartwarming stories of parents who were able to make informed decisions about their pregnancies due to the peace of mind the T21 test provided. The knowledge that one’s research has made a tangible difference in the lives of so many people is truly gratifying.

Looking Ahead: The Future of Diagnostics

With your new role as president of CUHK, what are some of your plans to drive medical research and innovation in Hong kong and beyond?

Professor Dennis Lo: I’m eager to foster a collaborative and innovative research habitat at CUHK, where scholars from diverse fields can work together to tackle global health challenges. I believe that interdisciplinary exchange is crucial for pushing the boundaries of what’s possible in medicine and diagnostics.

What do you think is the next big milestone in non-invasive diagnostics, and how can we, as a society, support its realization?

professor dennis Lo: I believe the future of non-invasive diagnostics lies in liquid biopsy applications – analyzing circulating biomarkers in blood for early cancer detection and monitoring, and also for personalized treatment. To support this, we need to invest in basic research, promote interdisciplinary collaborations, and encourage a regulatory environment that fosters innovation.

Professor Lo, your work has undeniably transformed prenatal care and opened new avenues in diagnostics. What keeps you motivated to continue pushing the boundaries of medical science?

Professor Dennis Lo: I’m driven by the knowledge that my work has the potential to make a real difference in people’s lives. There’s always more to discover, more to understand, and more to improve. It’s this infinite pursuit of knowledge and the chance to help others that keeps me going.

We extend our sincere gratitude to Professor Dennis Lo for taking the time to share his insights with Archyde.His groundbreaking discovery has undoubtedly left an indelible mark on the world of prenatal care, and we’re eager to witness the future advancements his work will continue to inspire.