2023-11-16 01:52:55
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Tag:
study
Breakthrough Treatment for Type 1 Diabetes: The Potential of DFMO
written by Alexandra Hartman Editor-in-Chief
2023-11-14 08:48:00
A study led by the Indiana University School of Medicine in collaboration with the University of Chicago (United States) has presented Future possibilities for the treatment of type 1 diabetes and the possible reduction of insulin dependence.
The researchers’ findings, published in Cell Reports Medicine, suggest that lThe reuse of the drug a-difluoromethylornithine (DFMO) can open doors to innovative therapies in the future.
Type 1 diabetes is a chronic condition in which the body’s immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas, causing high blood sugar levels that currently require insulin treatment. life to keep patients alive. Many people living with type 1 diabetes find that current treatments, including daily insulin injections and frequent blood sugar monitoring, They are uncomfortable and difficult to handle.
These latest translational results represent more than a decade of research. In 2010, the study’s corresponding co-author, Raghu Mirmira, was operating a research laboratory at the Indiana University School of Medicine in 2010 when his team initially discovered that Inhibition of the metabolic pathway affected by DFMO might protect to beta cells from environmental factors, suggesting possible preservation in type 1 diabetes. The team subsequently validated these findings in mice.
From 2015 to 2019, Edwin Letzter Professor of Pediatrics at Indiana University School of Medicine and pediatric endocrinologist and division chief at Riley Children’s Health, Linda DiMeglio, led a clinical trial that affirmed the safety of DFMO in newly diagnosed people. with type 1 diabetes and suggested that it might also stabilize insulin levels by protecting beta cells. The trial was funded by the Juvenile Diabetes Research Foundation (JDRF) with a drug provided by Panbela Therapeutics.
A pill can replace injections
“After several years of comparative studies, starting with Dr. Mirmira and Tersey’s mouse models, it is exciting to finally be able to share the promising results of our pilot trial in humans,” said the study’s lead author, Linda DiMeglio. “Now that we have established the preliminary safety of DFMO for people with type 1 diabetes“We are excited to advance our collaborative research to explore more of its potential benefits in a larger clinical trial,” he added.
“The use of a new formulation of DFMO in pill form It allows patients to take it orally instead of having to undergo regular injections, and it has a very favorable side effect profile,” says Mirmir. “It’s exciting to say that we have a drug that works differently than any other treatment we have. we have for this disease,” he adds.
The researchers have already begun their next steps to investigate the potential of DFMO. The study’s first author and co-author, Emily K. Sims, recently released a Larger six-center clinical study to robustly define the impact of DFMO treatment on preserving beta cell function in type 1 diabetes.
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#DIABETES #TREATMENT #diabetics #stop #daily #insulin #treatment #science
Elderly: a night on a stretcher in the emergency room increases the risk of mortality by 40%
written by Alexandra Hartman Editor-in-Chief
2023-11-09 11:01:18
The teams from AP-HP, Inserm, Sorbonne University, coordinated by Professor Yonathan Freund and Dr Mélanie Roussel (UFR santé de Rouen, University of Rouen Normandy) studied the mortality of elderly patients who had undergone a night in the emergency room on a stretcher while waiting for a hospitalization place. For the first time, scientific proof of excess mortality in these patients has been provided. This study, carried out with the methodological help of the URC EST Clinical Research Unit team of Professor Tabassome Simon (AP-HP and Sorbonne University), promoted by the AP-HP, was the subject of a publication in the journal JAMA Internal Medicine on November 6, 2023.
In December 2022, emergency services in France and Europe experienced a considerable increase in the number of patients requiring emergency hospitalization, including a large proportion of fragile and elderly patients. The hospital system might not effectively cope with such pressure due in part to a triple concomitant epidemic: COVID-19, influenza, and respiratory syncytial virus (RSV), a situation aggravated by a reduction in the number of beds available downstream of the hospital’s emergency departments. caused by a shortage of personnel. Thus, an unusually high number of elderly patients had to spend at least one night on a stretcher in the emergency room while waiting for a hospital place.
Several preliminary retrospective studies had suggested that this situation might worsen patient mortality, without this risk being able to be clearly established or quantified in the absence of a prospective study making it possible to formally establish a causal link. In particular, the quantification of the risk in the most fragile patients was lacking.
The study “ No Bed Night »
On an initiative of the Hospital-University Federation IMProving Emergency Care (FHU IMPEC) and with the support of the French Society of Emergency Medicine and Samu – Urgences de France, the study “ No Bed Night » was quickly put in place to assess the impact of this overload of emergency services, and its consequences on elderly patients. The study took place from December 12 to 14, 2022, in 97 emergency departments in France, including a total of 1,598 patients over the age of 75 hospitalized following going to the emergency room. After taking into account comorbidities and the initial severity of patients, this study shows that spending a night in the emergency room is associated with a significantly higher risk of in-hospital death: a night spent on a stretcher in the emergency room increases by almost 40% the risk of hospital mortality, which increases from 11.1% to 15.7%.
To illustrate these figures: if all the patients in this study had been able to be admitted to a hospital room before nightfall, 3% of deaths might have been avoided. This deleterious effect is confirmed on the risk of occurrence of complications during hospitalization (nosocomial infections, falls, bleeding, etc.).
“Among patients with a limited level of autonomy and requiring daily assistance, spending the night on a stretcher in the emergency room increases the risk of mortality by almost two times. »
In conclusion
This large prospective study of national scope, published in the journal JAMA Internal Medicine, shows that a night spent in the emergency room while waiting for a hospitalization place significantly increases the mortality of patients over 75 years old, and in particular that of older people. fragile. Measures must be taken to avoid this excess mortality as much as possible, and the objective of “ zero stretcher beds » in the emergency room, particularly for patients over 75 years old, must be considered a public health objective.
• References: Mélanie Roussel, Dorian Teissandier, Youri Yordanov, Frédéric Balen, Marc Noizet, Karim Tazarourte, Ben Bloom, Pierre Catoire, Laurence Bérard, Marine Cachanado, Tabassome Simon, Said Laribi, Yonathan Freund. JAMA Internal Medicine.
• The Risks of Being in Limbo in the Emergency Department Timothy S. Anderson, MD, MAS; Shoshana J. Herzig, MD, MPH JAMA Internal Medicine
• Interview with Yonathan Freund, MD, PhD, author of Overnight Stay in the Emergency Department and Mortality in Older Patients, and Timothy S. Anderson, MD, MAS, author of The Risks of Being in Limbo in the Emergency Department. Hosted by Louise Aronson, MD, MFA.
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#Elderly #night #stretcher #emergency #room #increases #risk #mortality
Launching the Medicine Degree at Loyola University Seville – Costs, Curriculum, and Campus Facilities
written by Alexandra Hartman Editor-in-Chief
2023-11-11 05:10:00
The Loyola University He hopes that before the end of 2023 he will begin teaching Medicine on the Seville campus. This is what sources from the Jesuit institution have made known following the General Council of Universities has given approval to the study plan of said degree, which had been questioned in spring by the Agency for Scientific and University Quality of Andalusia (water). For this reason, the Board is urged to approve the new degree before December, the time frame that the private center has to develop the first course of this education “under normal conditions.”
The announcement of a new Medicine degree in Seville aroused the interest of many students, which is why last April 180 applicants took the specific access test for this degree, opting to occupy the 60 planned places. Many of them performed this exercise given the high cut-off mark that this degree registers at the University of Seville (US), for which a grade higher than 13 is required.
The high score is mainly motivated by the high demand registered by these studies, for which there is not yet a very wide offer in Hispalense. Faced with such a limitation, many young people choose to go to other public universities where the cut-off grade is lower or to go to private education. A possibility, however, that requires good financial support that not all students have.
The cost of the first year
The figures confirm this other important “filter.” Loyola University itself publishes the price of the degrees on its website. Medicine is the most expensive. The first year of the degree costs 14,200 euros per student. This includes the price of the place reservation, which reaches 2,300 euros (also the highest), the registration fee (700) and the credits, 225 euros. The first course consists of 60 credits, like the rest of the degrees that are not double.
Loyola’s pricing policy clarifies that the payment to be made for reserving a place corresponds to the amount that, voluntarily, the applicant to occupy a position in a degree program pays. With this amount, the place is reserved, which will be formalized within the period established for this procedure. This money is then applied to official tuition. In the case of Medicine, as it is much higher than the tuition price, the difference will serve as an advance payment for the monthly payments that correspond to the academic year.
Monthly fees are calculated by multiplying the price of the credit by the number of credits required each course. The resulting amount is divided by the number of months in which the payment of the subjects for which the student has enrolled each semester is divided.
Hospital simulation
The fact that the price of credit in Medicine is the most expensive is due to the extensive instruments and services that the Loyola Faculty of Health has been provided with to teach this degree. Its facilities – in which 30 million euros have been invested – have pioneering equipment in this type of teaching: delivery room, operating room, critical care room, ICU room, triage, five consulting rooms and a multifusion room.
Sources from the Jesuit university specify that the order of the candidates to occupy the places is formed with the Baccalaureate and Selectivity grades and those of the specific test. All of this in the event that, once the degree is approved by the Andalusian Government, the demand for students continues to exceed the supply of 60 places. For now, it will only be taught on the Seville campus.
After Medicine, the highest prices for the first course at Loyola are found in two other health majors. Physiotherapy and Nursing, both with 11,200 euros per student. This second degree also faced the negative opinion of Accua in May. The General Council of Universities endorsed it at the end of summer and it received the approval of the Board at the beginning of the 2023/24 academic year, which allowed it to launch its studies in mid-October on the Seville and Córdoba campuses. The reservation of a place in both degrees costs 1,800 euros and the credits, 175.
Validation with the public
There are students who plan to start a career at a private university and then continue it at a public university. This “transfer” is not as easy as you might initially think. The first requirement is the cut-off mark of the degree, which must always be achieved. It must be remembered here that The Selectivity note is valid for two years.
The other factor is the validation of credits by subjects, which is now at the discretion of the teaching committees of each university. These bodies decide whether the syllabi of a subject taught in one academic institution and in another have the same level of knowledge. These criteria regulate the validation of studies between universities, whether public or private.
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#cost #study #Medicine #Loyola #University #Seville