Scientists at the University of Sydney have invented a combination drug for lowering blood pressure, which consists of four known drugs for hypertension in low doses and works more effectively than either drug alone. The results of the clinical trial of the combination drug published in the journal The Lancet and were presented at the ESC Congress 2021 conference of the European Society of Cardiology.
High blood pressure causes heart attacks and strokes. Moreover, it is found in most people after 50 years. Although not many of them measure their blood pressure on a daily basis, right and know new normal pressure gold standard.
The lead author of the new study, Clara Chou (Clara Chow) from the University of Sydney considersthat the control of hypertension is nowhere in the world perfect, and in Africa, hypertension is under control in less than one in ten.
“World statistics showsthat over the past 30 years, the number of cases of hypertension has doubled, and hypertension has become the leading cause of death from heart attack and stroke, “says Chow.
As a result, people often go to the doctor with very high blood pressure. In such cases, doctors prescribe one or two drugs in high doses, from which the liver and kidneys suffer. If these drugs do not relieve blood pressure, experiment with the following. But often, such patients, experiencing the side effects of the drug – pain due to high doses of the drug, stop taking the drugs altogether and, therefore, live with a constant risk of heart attack or stroke.
“We wanted to see if people who have severe side effects from treatment would benefit from switching to an ultra-low dose combination. [препаратов]”- explains Professor Chow.
To reduce the toxic effects of strong drugs on the body and effectively lower blood pressure, Australian scientists have combined four well-known drugs in one tablet – irbesartan at a dose of 37.5 mg, amlodipine at a dose of 1.25 mg, indapamide at a dose of 0.625 mg and bisoprolol at a dose of 2.5 mg. Typically, these drugs are prescribed in minimum doses of 75 mg, 5 mg, 1.5 mg, and 2.5 mg, respectively.
Combined drug experienced on two groups of adult Australian residents totaling 591 people. The first group received a new 4-in-1 pill. The second group, the control group, took only one medication for hypertension, which is usually prescribed by doctors.
As a result, after 12 weeks of testing, blood pressure decreased in 80% of patients from the first group and in 60% of patients from the control group.
After 12 months, the decrease in blood pressure in the first group of patients was even more stable than in the control group of patients with a standard approach to the treatment of hypertension. However, no differences in side effects were observed.
“This was the first study to show that the benefits persist over the long term without any decline over time,” Chow emphasizes. [пациенты] used a lot more additional blood pressure medications, they never caught up [по эффективности] group with the drug 4 in 1 “.
However, creating an effective drug is not enough. It also needs to be made affordable for the majority of patients who need it, scientists say. Only in this case will the medicine have a serious impact on the global health of the inhabitants of the planet.
“When we find such an effective, simple and safe treatment“We must do our best to deliver it to those who will benefit the most,” says Chow.
Earlier we wrote about five-minute breathing exercises, which reduce pressure without pills, and exercisesthat will help lower blood pressure as well as medication. We also said that the “upper” and “lower” pressure equally affect on the risk of heart attack and stroke.