Inflammation is a biological response that occurs naturally in the body to heal damaged body tissues and remove harmful substances from the outside.
In a word, inflammation refers to the secretion of inflammatory substances by an immune response.
Chronic inflammation damages heart valves and brain cells, leading to heart disease and stroke. It also promotes insulin resistance, which increases the risk of diabetes and may even cause cancer.
Vitamin D deficiency is directly linked to chronic inflammation, a study has found. Researchers at the University of South Australia’s (UniSA) Cancer Institute’s Center for Precision Health, Dr. Elena Hiftenen, and colleagues analyzed data from UK Biobank of 244,970 people and found that this was true. The American Association for the Advancement of Science (AAAS) science news site EurekAlert reported on the 8th.
UK Biobank is a key infrastructure for future health care research such as precision medicine and bio-health industry. A large-scale prospective co-group study conducted from 2006 to 2009 with about 500,000 people (ages 37-73) recruited from 22 evaluation centers nationwide. to be. The purpose is to prevent, diagnose, and treat middle-aged and geriatric diseases.
The research team conducted a study using the Mendelian randomization method based on their genetic analysis data.
Mendelian randomized analysis is a research method that infers causality by analyzing the association between environmental risk factors for a specific disease and genetic mutations associated with it.
The research team analyzed whether there is a genetic link between vitamin D and C-reactive protein (CRP), an inflammatory marker in the body.
The researchers found a direct link between vitamin D deficiency and CRP excess.
CRP is an inflammatory marker protein that is released into the blood within hours of damage to body tissues. CRP collectively represents signals from several proteins (cytokines) involved in inflammation. CRP levels indicate the extent of a patient’s inflammatory activity.
These results suggest that maintaining adequate levels of vitamin D in the body can reduce the risk of chronic diseases related to inflammation, such as cardiovascular disease, diabetes, and autoimmune diseases, and reduce the severity of these diseases, the research team explained.
As obesity is also associated with inflammation, the research team speculated that it may reduce the risk of complications from obesity.
The results of this study demonstrate the importance of avoiding clinical deficiencies of vitamin D, the team emphasized.
Vitamin D is synthesized in the body through the skin exposed to the sun’s ultraviolet rays. Sun exposure provides 90% of the vitamin D our body needs. Among foods, it is found in oily fish (salmon, tuna, mackerel), liver, egg yolk, and cheese, and can also be consumed through vitamin D-added cereals, milk, and vitamin D supplements.