BA.2.86 Mutation: Concerns over Immune Evasion and Global Spread

2023-08-26 22:08:30

Delta and Omicron have a high number of mutations

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Concerns arose that BA.2.86. could have the highest level of immune evasion among all Omicron mutations. [사진=게티이미지뱅크]The US health authorities warned that a new strain of Corona 19 discovered in the United States just a week ago could neutralize the immunity obtained through vaccines or infection with existing mutants, so caution is required. This is a very unusual measure, the health and medicine portal WebMD reported on the 24th (local time).

The mutation of interest is BA.2.86, which was first detected in the United States on the 17th. It was the very day the World Health Organization (WHO) designated it a ‘surveillance variant’ (VUM). At the time, the mutation made health experts nervous even though only seven cases had been found in four countries: Denmark, Israel, the United States and the United Kingdom. This mutation, nicknamed ‘Pirola’, is a sub-variant of the Omicron mutation BA.2, but the number of mutations in the spike protein is 36 more than that of BA.2. because there was a concern that

And six days later, on the 23rd, the US Centers for Disease Control and Prevention (CDC) said, “BA.2.86 is more likely to infect people who have previously been infected with Corona 19 or who have received the Corona 19 vaccine,” and said that special attention is required. . The number of mutations in BA.2.86 is similar to the difference between mutations that are so severe that they are officially named, such as Delta and Omicron.

The CDC said it is also evaluating how well an updated vaccine, scheduled for release in September, works against BA.2.86. The CDC said there was “no evidence” that BA.2.86 causes more severe disease. However, he added that this may change as more information is coming. Health professionals typically measure the severity of COVID-19 by hospitalization rates.

The CDC expects hospitalizations for COVID-19 infections to continue rising through at least mid-September. Currently, about 1,800 corona patients are hospitalized every day, but there is a risk of increasing up to 7,500 a day. The most likely scenario is between 2,000 and 4,000 hospitalizations per day through September 18, which falls somewhere in between.

Scientists have found similarities between the appearance of BA.2.86 and the rapid global appearance of Omicrons in November 2021, Nature recently reported. Adam Loring, a virologist at the University of Michigan who discovered one of the first cases of BA.2.86 in the United States, says more data is needed to fully understand the threat of BA.2.86, but he feels a sense of déjà vu seeing Omicron again.

Meanwhile, the WHO announced on the 24th (local time) that the number of countries where BA.2.86 was detected increased to six, including Israel, Denmark, the United States and the United Kingdom, as well as Switzerland and South Africa. All of these countries have one thing in common: they have strong genetic sequencing capabilities. For this reason, there are concerns that it may not be caught in time due to loosened surveillance of Corona 19, although it is already spreading widely in other countries with poor analysis capabilities.

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