2023-12-21 00:25:32
Research results show that Benidipine (calcium channel blocker (CCB)) promotes the death of aging cells caused by cigarette smoke and improves emphysema. Aging It was published in the 12th issue of the journal.
Smoking is a major risk factor for many lung diseases, including chronic obstructive pulmonary disease (COPD), and cigarette smoke contains carcinogenic and reactive oxygen species that promote DNA mutation and disrupt cellular homeostasis and the environment.
Using a library of FDA-approved drugs, the French research team performed a chemical screen to identify compounds that selectively promote cigarette smoke-induced death of aging lung cells.
The goal of the study is to identify anti-aging compounds in the context of cigarette smoke-induced aging and evaluate whether they improve emphysema.
In addition to the well-known anti-aging agent ABT-263, the study identified other new potential anti-aging compounds, including a new class of molecules, the dihydropyridine family of calcium voltage-gated channel (CaV) blockers. did.
Among these blockers, benidipine reduced senescent lung cells and showed improvement in emphysema in a mouse model.
The dihydropyridine family of CaV blockers constitutes a new class of anti-aging agents that may improve lung disease, the research team said.
“This study paves the way for further research into the anti-aging activity of CaV blockers in other aging contexts and age-related diseases,” the researchers wrote.
Identification of CaV blockers as a potential new class of senolytics
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