Brain cancer: beware of head trauma

A number of studies suspected a possible link between head injuries and brain tumors. In the absence of conclusive evidence, the researchers left it at that. But a recent publication has just identified a convincing mechanism to explain this link. These would be genetic mutations (of the p53 gene to be precise) which, together with inflammation of brain tissue, modify the behavior of cells (astrocytes), making them eventually, with aging, likely to become cancerous. And to statistically confirm what the researchers studied in mice cells, their team looked at the medical records of more than 20,000 people with traumatic brain injury and compared the rate of brain cancer with that of a control group. . Patients with head trauma were almost four times more likely to develop brain cancer later in life than those without a head injury. To alleviate fears, however, the researchers point out that “the risk of developing brain cancer is low overall, estimated at less than 1% over a lifetime, so even after trauma the risk remains modest ».

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