2023-09-24 07:08:37
When the immune system attacks the body’s own tissue, it is an autoimmune disease. So far, neither multiple sclerosis nor lupus, rheumatoid arthritis or diabetes I have been cured. Now researchers have achieved a breakthrough that holds out the prospect of a real cure. They have invented a so-called “inverse vaccination” that makes it clear to the immune system: You should not fight these structures! It has already worked on mice and monkeys.
Will a vaccination soon help against diseases like MS?
This vaccination specifically defuses the immune system
Vaccinations actually sharpen the immune system, so to speak, so that it can better recognize dangerous germs and destroy them quickly. Researchers at the Pritzker School for Molecular Engineering at the University of Chicago have flipped the concept and defused a misdirected immune response. To do this, the scientists used an existing mechanism: the so-called acquired immune system marks harmless particles and then leaves them alone. For example, foreign molecules that enter the liver through food are tolerated. To trigger the tolerance mechanism, they coupled the sugar molecule pGal, which was identified as friendly, to an antigen that triggers an excessive immune response. They injected the mixture into mice that had either just received MS induction or were already ill.
Vaccination had a preventive and even a curative effect
In multiple sclerosis, the T cells of the immune system attack the myelin layer that protects our nerves. Whether the induction of MS in the rodents was zero, three or six days ago, the result always remained the same: the disease did not break out after the inverse vaccination. But what was particularly surprising was that the animals that were already sick experienced a significant improvement. When the disease was very recent, there was only very low MS activity; a slightly later vaccination still resulted in a significantly reduced autoimmune reaction. Rodents suffering from relapsing multiple sclerosis did not experience a relapse within the 50-day study. Paralysis, visual impairments and movement problems always disappeared.
Further experiments with primates produced similar results; the monkeys’ false immune reaction could be prevented over a period of at least 13 weeks. There is therefore great hope that these experiments will result in a new method of prevention and an effective treatment leading to a complete cure.
Those: derstandard.at
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